A5069568554- Maternal and Perinatal Health Interventions
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Congenital Anomalies and Fetal Surgery
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Global Maternal and Child Health
- Neonatal Respiratory Health Research
- Parvovirus B19 Infection Studies
- Pregnancy and Medication Impact
- Pelvic floor disorders treatments
- Healthcare Policy and Management
- Pregnancy-related medical research
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Preterm Birth and Chorioamnionitis
- Eosinophilic Esophagitis
- COVID-19 Impact on Reproduction
- Disability Rights and Representation
- Ureteral procedures and complications
- Reproductive System and Pregnancy
- Congenital Heart Disease Studies
- COVID-19 and healthcare impacts
- Geriatric Care and Nursing Homes
Karolinska Institutet
2014-2024
Karolinska University Hospital
2014-2024
Stockholm South General Hospital
2006-2022
UNSW Sydney
2022
Uppsala University
2020
Sahlgrenska University Hospital
2020
University of Gothenburg
2017-2020
National Academy of Medicine
2020
Örebro University
2020
Center for Clinical Research Dalarna
2020
Excessive bleeding is one of the major threats to women at childbirth. The aim this study was validate estimation blood loss during delivery.Bleeding estimated after 29 elective cesarean sections and 26 vaginal deliveries compared measured by extraction hemoglobin using alkaline hematin method, according Newton.Inter-individual agreement showed good results. Estimated in comparison with resulted an over-estimation. In vaginally delivered women, there no correlation between (r2=0.13),...
To evaluate if induction of labour at 41 weeks improves perinatal and maternal outcomes in women with a low risk pregnancy compared expectant management 42 weeks.Multicentre, open label, randomised controlled superiority trial.14 hospitals Sweden, 2016-18.2760 uncomplicated singleton (1:1) by the Swedish Pregnancy Register. 1381 were assigned to group 1379 group.Induction weeks.The primary outcome was composite including one or more stillbirth, neonatal mortality, Apgar score less than 7...
David Baud, MD, PhD; Gilbert Greub, Guillaume Favre, MD; Carole Gengler, Katia Jaton, Estelle Dubruc, Léo Pomar, MSc
Background Asthma is one of the most common chronic diseases, and prevalence, severity medication may have an effect on pregnancy. We examined maternal asthma, asthma control in relation to pregnancy complications, labour characteristics perinatal outcomes. Methods retrieved data all singleton births from July 1, 2006 December 31, 2009, prescribed drugs physician-diagnosed same women multiple Swedish registers. The associations were estimated with logistic regression. Results In total, 266...
To compare the antenatal detection rate of malformations in chromosomally normal fetuses between a strategy offering one routine ultrasound examination at 12 gestational weeks (gws) and 18 gws.Randomised controlled trial.Multicentre trial including eight hospitals.A total 39,572 unselected pregnant women.Women were randomised either to scan (12-14) gws nuchal translucency (NT) measurement or (15-22) gws. Anomaly screening was performed both groups following check-list. A repeat offered...
Abstract Objectives To determine the accuracy of established ultrasound dating formulae when used at 12–14 weeks gestation. Methods One‐hundred and sixty‐seven singleton pregnancies conceived after in‐vitro fertilization (IVF) underwent a scan Gestational age was calculated by adding 14 days to number between date oocyte retrieval scan. according regarded as true gestational age. True compared on basis 21 based fetal crown–rump length (CRL) measurements three biparietal diameter (BPD)...
Objective To compare the rate of prenatal diagnosis heart malformations between two policies screening for malformations. Design Randomised controlled trial. Setting Six university hospitals, district general hospitals. Sample A total 39 572 unselected pregnancies randomised to either policy. Methods The 12‐week policy implied one routine scan at 12 weeks including measurement nuchal translucency (NT), and 18‐week 18 weeks. Fetal anatomy was scrutinised using same check‐list in both groups,...
Despite the seriousness of event, maternal deaths are substantially underreported. There is often a missed opportunity to learn from such tragedies. The aim study was identify in five Nordic countries, classify causes death based on internationally acknowledged criteria, and areas that would benefit further teaching, training or research possibly reduce number deaths.We present data for years 2005-2013. National audit groups collected by linkage registers direct reporting hospitals. Each...
Abstract To evaluate associations between maternal anxiety or depression and adverse pregnancy outcomes, taking possible familial confounding interaction with asthma into account, we conducted a cohort study of all singleton births in Sweden 2001–2013. We retrieved information about pregnancy, diagnoses anxiety/depression, asthma, prescribed medication from the Swedish Medical Birth, National Patient, Prescribed Drug Registers. estimated regression models, performed cousin sibling...
Abstract: Background: Fetal screening for Down syndrome by an ultrasound examination, including measurement of fetal nuchal translucency, at 12 to14 weeks’ gestation is presently being evaluated in a Swedish randomized controlled trial. Women high risk were offered amniocentesis to obtain definite diagnosis. The aim this study was explore women's reactions and responses information about after the scan, with special focus on false positive test . Method: Interviews conducted 24 women within...
To identify factors related to retained placenta in the context of contemporary obstetric practice.This was a case-control study comparing 408 cases and an equivalent number control individuals. Epidemiological delivery-related variables were registered computerized prenatal in-hospital medical records. Univariable multivariable logistic regressions used for estimation risk ratios statistical significance.Independent were: previous (odds ratio [OR] 12.61, 95% confidence interval [CI]...
Objective To evaluate whether defective placentation disorders, i.e. pre‐eclampsia, stillbirth, small for gestational age ( SGA ), and spontaneous preterm birth, are associated with risk of retained placenta. Design Population‐based cohort study. Setting Sweden. Population Primiparous women in Sweden singleton vaginal deliveries between 1997 2009 at 32–41 weeks gestation n = 386 607), without placental abruption or infants congenital malformations. Methods Risks were calculated as odds...
The literature describes advantages for mothers giving birth in water, but waterbirth is controversial Sweden and has not been offered at hospitals until recently. This study aimed to describe compare the characteristics outcome of waterbirths with those spontaneous vaginal births same clinics.A retrospective cohort was conducted on all two maternity units from March 2014 November 2015 (n = 306), a consecutively selected comparison group 306 women having conventional births. Logistic...
Abstract Introduction The Stockholm region was the first area in Sweden to be hit by pandemic caused severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). national guidelines on care of women with a positive test for SARS‐CoV‐2 (detection polymerase chain reaction [PCR]) recommend individualized antenatal care, mode delivery based obstetric considerations, and no routine separation mother newborn. Breastfeeding is encouraged, although there specific recommendation regarding wearing...
Abstract Objectives To determine the accuracy of established ultrasound dating formulae when used at 12–14 and 15–20 gestational weeks. Methods A total 363 singleton pregnancies conceived after in‐vitro fertilization (IVF) randomized to a scan or weeks were studied. ‘True’ age was calculated on basis day oocyte retrieval compared seven including fetal biparietal diameter (BPD) three BPD femur length (FL). The mean differences between estimated true (systematic measurement error) their SD...
Background. Screening for fetal abnormality may increase women's anxiety as attention is directed at the possibility of something being wrong with baby. The aim this study was to evaluate effect ultrasound screening Down's syndrome on in mid‐pregnancy and 2 months after delivery. Method. Two thousand twenty‐six women were randomly allocated an examination 12–14 gestational weeks (gws) including risk assessment or a routine scan 15–20 gws. Questionnaires State‐Trait Anxiety Inventory (STAI),...
Abstract Objectives Nuchal translucency (NT) screening increases antenatal detection of Down syndrome (DS) compared to maternal age‐based screening. We wanted determine if a change in policy for prenatal diagnosis would result fewer babies born with DS. Methods A total 39 572 pregnant women were randomized scan at 12–14 gestational weeks including NT DS (12‐week group) or 15–20 based on age (18‐week group). Fetal karyotyping was offered risk according ≥ 1:250 the 12‐week group and 35 years...
Abstract Objective In this study we aimed to estimate the magnitude of a possible increase in risk adverse outcome fetuses with normal karyotype and increased nuchal translucency (NT), determine how well NT measurements can distinguish between outcome. Methods We studied 16 260 consecutive derived from an unselected pregnant population. The following cut‐offs for were chosen priori: ≥ 95th percentile, 3 mm, 3.5 4.5 mm. positive negative likelihood ratios (+LR, − LR) regard fetal...
Objective: Intrapartum antibiotic prophylaxis (IAP) reduces the incidence of neonatal early onset group B streptococcal infections. The present study investigated if an automated PCR-assay, used bedside by labor ward personnel was manageable and could decrease use IAP in a setting with risk-based strategy.Methods: comprises two phases. Phase 1 multicenter, randomized, controlled trial. Women selected risk-factors were allocated either to PCR-IAP (prophylaxis given positive or indeterminate)...
Asthma is associated with several adverse pregnancy and perinatal outcomes. Familial factors may confound these associations.To examine the role of measured unmeasured confounding by conducting a study that compared differentially exposed cousins siblings from same families.We retrieved data on outcomes, prescribed drugs, physician-diagnosed asthma nationwide registers for all women in Sweden singleton births between 2001 2013. Logistic linear regression estimated association maternal...
Observational data shows that postterm pregnancy (≥42 gestational weeks, GW) and late term (≥41 GW), as compared to pregnancy, is associated with an increased risk for adverse outcome the mother infant. Standard care in many countries induction of labour at 42 GW. There insufficient scientific support 41 GW, expectant management GW will reduce perinatal mortality morbidity without increase operative deliveries, negative delivery experiences or higher costs. Large randomised studies are...