A5101684410- Inflammatory Bowel Disease
- Gut microbiota and health
- Microscopic Colitis
- Inflammatory mediators and NSAID effects
- Adolescent and Pediatric Healthcare
- Eicosanoids and Hypertension Pharmacology
- Interprofessional Education and Collaboration
- Health Sciences Research and Education
- Gastrointestinal motility and disorders
- Veterinary Practice and Education Studies
- Connexins and lens biology
- Renin-Angiotensin System Studies
- Hydraulic and Pneumatic Systems
- Systemic Sclerosis and Related Diseases
- Retinal Development and Disorders
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- 3D Printing in Biomedical Research
- Electric and Hybrid Vehicle Technologies
- melanin and skin pigmentation
- Dental Education, Practice, Research
- Health and Medical Research Impacts
- Cholinesterase and Neurodegenerative Diseases
- Diversity and Career in Medicine
- Oil and Gas Production Techniques
National Institute of Mental Health
2024-2025
National Institutes of Health
2024
Brown University
2023-2024
National Eye Institute
2022
UNSW Sydney
1968-2015
Shell (Netherlands)
2009
University of Manitoba
2009
Rockefeller University
1968
Cyclooxygenase-2 (COX-2) is present in a healthy brain at low densities but can be markedly upregulated by excitatory input and inflammogens. This study evaluated the sensitivity of PET radioligand [<sup>11</sup>C]-6-methoxy-2-(4-(methylsulfonyl)phenyl)-<i>N</i>-(thiophen-2-ylmethyl)pyrimidin-4-amine ([<sup>11</sup>C]MC1) to detect COX-2 density human brain. <b>Methods:</b> The specificity [<sup>11</sup>C]MC1 was confirmed using lipopolysaccharide-injected rats transgenic mice expressing...
Specimens of intestinal mucosa rats were examined closely to determine the distribution mucosa-associated microbial flora. Six distinct zones found along length tract. The first zone, in small intestine 50 cm or more from ileocaecal junction, had no associated flora: however, each five other different populations microorganisms with mucosa. Some these organisms have not been reposted previously. Treatment oral doses purgative magnesium sulphate resulted dramatic changes microorganisms....
In Brief Purpose Evidence-based practice (EBP) is an essential component of good quality, patient-centered health care. This requires practitioners to acquire EBP skills and knowledge during undergraduate continuing education. education exists in a range care disciplines, including optometry. education, however, depends on relevant educators. Courses workshops exist for the development teaching some areas but not Here, we describe pilot workshop designed enhance investigate perspectives...
The conformations of peptides and proteins are often influenced by glycans O-linked to serine (Ser) or threonine (Thr). (2S,4R)-4-Hydroxyproline (Hyp), together with L-proline (Pro), interesting targets for O-glycosylation because they have a unique influence on peptide protein conformation. In previous work we found that glycosylation Hyp does not affect the N-terminal amide trans/cis ratios (K(trans/cis)) rates isomerization in model amides. stereoisomer Hyp--(2S,4S)-4-hydroxyproline...
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Summary The Penguins field comprises of a cluster reservoirs in the northern North Sea. need for gas lift was foreseen during early stages field-development planning. Five oil wells were completed service. A 65-km 4-in. line laid 2006, running alongside production and tied into drill centers by flexible 2-in. jumpers. Because unconventionally long distance from platform, it necessary to carry out transient modeling full commissioning startup process. Particular attention required, both...
Phosphodiesterase-4D (PDE4D) has emerged as a significant target for treating neuropsychiatric disorders, but no PET radioligand currently exists robustly quantifying human brain PDE4D to assist biomedical research and drug discovery. A prior candidate radioligand, namely [<sup>11</sup>C]T1650, failed in humans because of poor time stability PDE4D-specific signal (indexed by total volume distribution), likely due radiometabolites accumulating brain. Its nitro group was considered be source...
Lay Summary Patient participation is crucial to learning health systems that leverage patient data improve care practices. Age, history of anxiety or depression, and frequency clinic visits were associated with inactive in an inflammatory bowel disease system.
Background: A CLCC1 c. 75C &gt; (p.D25E) mutation has been associated with autosomal recessive pigmentosa in patients and from Pakistan. is ubiquitously expressed, knockout models of this gene zebrafish mice are lethal the embryonic period, suggesting that possible retinitis mutations might be limited to those leaving partial activity. In agreement hypothesis, only date, all identified share a common SNP haplotype surrounding mutation, founder. Methods: SNPs were genotyped by combination...
Whilst full-toroidal traction drives (IVT and TCVT) have demonstrated the ability to provide significant fuel economy, emissions cost benefits across a wide range of applications, increased emphasis is now being placed on power density. Increased density places demands variator elements fluid withstand heavily loaded rolling contact conditions corresponding temperature increase. In this paper, drive meet accelerated durability testing requirements 50,000km at max vehicle speed experimentally...
Abstract BACKGROUND Patient-provider co-production of care is integral to managing inflammatory bowel diseases (IBD), chronic and incurable conditions that affect patients’ quality life. Patients in the IBD Qorus Learning Health System self-report symptoms treatment goals prior clinic visits via electronic surveys, which helps their providers develop patient-centered plans. This study examines factors predict active participation program inform future strategies promote programmatic...