A5024191777- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- Calcium Carbonate Crystallization and Inhibition
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Orthopaedic implants and arthroplasty
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- Collagen: Extraction and Characterization
- Liver Disease Diagnosis and Treatment
- AI in cancer detection
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Dyeing and Modifying Textile Fibers
- Image Retrieval and Classification Techniques
- Electrochemical sensors and biosensors
- Microfluidic and Capillary Electrophoresis Applications
- Dental Implant Techniques and Outcomes
- Titanium Alloys Microstructure and Properties
- Polymer Foaming and Composites
- Analytical Chemistry and Sensors
- Liver physiology and pathology
Grigore T. Popa University of Medicine and Pharmacy
2013-2023
University of Nottingham
2018-2023
University of Cambridge
2018-2019
Gheorghe Asachi Technical University of Iași
2009-2013
Hydrogels are an attractive class of biomaterials in tissue engineering due to their inherently compatible properties for cell culture. Gelatin methacryloyl (GelMA) has shown significant promise the fields and drug delivery, as its physical can be precisely tuned depending on specific application. There is a growing appreciation interaction between cells immune system with increasing usage vivo applications. Here, we addressed current lack information regarding immunogenicity...
This work reports on the physicochemical properties and in vitro cytotoxicity assessment of chitosan–calcium phosphate (Cs–CP) scaffolds for bone tissue engineering, which were synthesized by a novel biomimetic co-precipitation method. X-ray diffraction (XRD) along with scanning electron microscopy (SEM) analysis confirmed porous morphology amorphous nature inorganic phase different crystallite sizes formation various forms calcium phosphate. Compressive mechanical testing revealed that...
Abstract A novel biomimetic technique for obtaining chitosan—calcium phosphates (Cs‐CP) scaffolds are presented: calcium precipitated from its precursors, CaCl 2 and NaH PO 4 on the Cs matrix, under physiological conditions (human body temperature fluid pH; 37 o C pH = 7.2, respectively). Materials composition structure have been confirmed by various techniques: elemental analysis, Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), energy dispersive (EDX), scanning...
Liver fibrosis is a complex, dynamic process associated with broad spectrum of chronic liver diseases and acute failure, characterised by the dysregulated intrahepatic production extracellular matrix proteins replacing functional cells scar tissue. Fibrosis progresses due to an interrelated cycle hepatocellular injury, triggering persistent wound-healing response. The accumulation tissue inflammation can eventually lead cirrhosis carcinoma. Currently, no therapies exist directly treat or...
Abstract Cartilage wounds result in chronic pain and degradation of the quality life for millions people. A synthetic cellular scaffold able to heal damage by substituting natural tissue is great potential value. Here, it shown first time that unique interplay between molecular components cartilage can be reproduced composite materials made a polyelectrolyte hydrogel embedding collagen scaffold. These composites possess mechanical response determined osmotic electrostatic effects, comparable...
Abstract Tissue engineering response may be tailored via controlled, sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional (3D) ice-templated collagen scaffolds. However, the effects covalent crosslinking during scaffold preparation on availability and protein have not been explored. Here, we load 3D scaffolds with controlled additions poly-(DL-lactide-co-glycolide) microparticles. We probe subsequent...
Composites based on calcium phosphates (CP) and mixtures of biopolymers (chitosan hyaluronic acid) have been prepared by a biomimetic co-precipitation method tested as scaffolds for bone tissue engineering. The strategy is inspired natural mineralization processes, where the synthesized minerals are usually combined with proteins, polysaccharides or other mineral forms to form composite, in physiological conditions temperature pH. Fourier transformed infrared spectroscopy, scanning electron...
Chitosan-Hydroxyapatite (Cs-Hap) composites were prepared through a biomimetic method by Hap precipitation from its precursors, CaCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and NaH PO xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> , on the chitosan fibres. Materials composition structure have been analyzed usual analytical techniques, Fourier transform infrared spectroscopy (FT-IR) scanning electron microscopy (SEM). FT-IR...