A5051399209- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Infectious Aortic and Vascular Conditions
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal vascular conditions and treatments
- Central Venous Catheters and Hemodialysis
- Trauma Management and Diagnosis
- Reconstructive Surgery and Microvascular Techniques
- Surgical site infection prevention
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Renal and Vascular Pathologies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pelvic and Acetabular Injuries
- Immune Response and Inflammation
- Muscle and Compartmental Disorders
- Cardiac and Coronary Surgery Techniques
- Trauma and Emergency Care Studies
Albany Medical Center Hospital
2020-2025
University of Maryland, Baltimore
2013-2017
University of Maryland Medical Center
2013-2015
University of Michigan
2010-2015
Blunt cerebrovascular injury (BCVI) is reported to occur in approximately 2% of blunt trauma patients, with a stroke rate up 20%. Guidelines for BCVI screening are based on clinical and radiographic findings. We hypothesized that liberal the neck vasculature, as part initial computed tomographic (CT) imaging patients significant mechanisms injury, identifies may go undetected.As per protocol, at risk injuries undergo noncontrast head CT scan followed by multislice (40-slice or 64-slice)...
It is hypothesized that differential AKT phosphorylation between sexes important in abdominal aortic aneurysm (AAA) formation. Male C57BL/6 mice undergoing elastase treatment showed a typical AAA phenotype (80% over baseline, P < 0.001) and significantly increased phosphorylated AKT-308 (p308) total-AKT (T-AKT) at day 14 compared with female mice. Elastase-treated Raw cells produced p308 significant amounts of matrix metalloproteinase 9 (MMP-9), these effects were suppressed by LY294002...
Grade 4 blunt cerebrovascular injury (BCVI4) has a known, significant rate of stroke. However, little is known about the natural history BCVI4 and pathophysiology subsequent stroke formation.A 4-year review patients with at R Adams Cowley Shock Trauma Center was performed. Rates BCVI4-related stroke, stroke-related mortality, overall mortality were calculated. The relationship change in vessel characteristics examined, as mechanism formation.There 82 BCVI4s identified, 13 carotid artery...
The serine proteases, along with their inhibitor plasmin activator inhibitor-1 (PAI-1), have been shown to play a role in abdominal aortic aneurysm (AAA) formation. aim of this study is determine if PAI-1 may be protective factor for AAA formation and partially responsible the gender difference observed AAAs. Male female wild-type (WT) C57BL/6 PAI-1(-/-) mice 8-12 wk age underwent perfusion porcine pancreatic elastase. Animals were harvested 14 days following analyzed phenotype, protein...
Deep-vein thrombosis (DVT) resolves via a sterile inflammatory response. Defining the response of DVT may allow for new therapies that do not involve anticoagulation. Previously, we have shown Toll-like receptor 9 (Tlr9) gene deleted mice had impaired venous (VT) resolution. Here, further characterise role Tlr9 signalling and inflammation in chronic VT vein wall responses. First, found human precedent exists with Tlr9+ cells present post thrombotic intraluminal tissue. Second, stasis mouse...
BACKGROUND The short-term natural history of blunt cerebrovascular injuries (BCVIs) has been previously described in the literature, but purpose this study was to analyze long-term serial follow-up and lesion progression BCVI. METHODS This is a single institution's retrospective review prospectively collected database over four years (2009–2013). All patients with diagnosis BCVI by computed tomographic (CT) scan were identified, graded based on modified Denver scale. Management followed...
Deep vein thrombosis (VT) can result in wall injury, which clinically manifests as post-thrombotic syndrome. Postinjury fibrosis may be modulated part through cellular cysteine-cysteine receptor 7 (CCR7)-mediated events. We tested the hypothesis that late fibrotic remodeling is dependent on CCR7.CCR7(-/-) and C57BL/6 wild-type mice had inferior vena cava VT induced by nonstasis or stasis mechanisms. In both models, size was largest at day 1 trended down 21, CCR7(+) cells peaked 8 mice. No...