A5052034879- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Protease and Inhibitor Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Congenital Diaphragmatic Hernia Studies
- Central Venous Catheters and Hemodialysis
- Atrial Fibrillation Management and Outcomes
- Diversity and Career in Medicine
- Electrospun Nanofibers in Biomedical Applications
- Global Security and Public Health
- Organ Transplantation Techniques and Outcomes
- Artificial Immune Systems Applications
- Surgical Simulation and Training
- Renal Transplantation Outcomes and Treatments
- Intelligence, Security, War Strategy
- Innovations in Medical Education
University of Michigan
2012-2024
Michigan United
2024
Michigan Medicine
2017-2023
C. S. Mott Children's Hospital
2013-2023
Society of Thoracic Surgeons
2012
Abstract Background Adult patients surviving with congenital heart disease (ACHD) is growing. We examine the factors associated transplant outcomes in this challenging population complex anatomy requiring redo-surgeries. Methods reviewed United Network for Organ Sharing-Standard Transplant Analysis and Research database analyzed 35,952 transplants from January 1st, 2000, to September 30th, 2018. compared characteristics ischemic cardiomyopathy (ICM) (n = 14,236), nonischemic (NICM) 20,676),...
Objective— Toll-like receptors (TLR) bridge innate immunity and host responses, including inflammation. Sterile inflammation such as a venous thrombus (V t ) may involve TLR signaling, TLR9. Methods Results— TLR9 signaling on resolution was investigated using mouse model of stasis V . were significantly larger in TLR9−/− mice compared with wild-type (WT) at 2 8 days, despite 2-fold increase polymorphonucleic neutrophils days monocytes whereas collagen neovascularization 55% 37% less,...
Summary Deep-vein thrombosis (DVT) resolution is thought to be primarily a urokinase plasminogen activator (uPA) -dependent mechanism, although observations suggest other non-fibrinolytic mechanisms may exist. We explored the role of matrix metalloproteinase (MMP) -2 and –9 in early DVT uPA-deficient mice. Male B6/SVEV (WT) genetically matched uPA -/- mice underwent inferior vena cava (IVC) ligation create stasis venous thrombi, with IVC thrombus harvest. Thrombus size was similar between WT...
Deep vein thrombosis (VT) can result in wall injury, which clinically manifests as post-thrombotic syndrome. Postinjury fibrosis may be modulated part through cellular cysteine-cysteine receptor 7 (CCR7)-mediated events. We tested the hypothesis that late fibrotic remodeling is dependent on CCR7.CCR7(-/-) and C57BL/6 wild-type mice had inferior vena cava VT induced by nonstasis or stasis mechanisms. In both models, size was largest at day 1 trended down 21, CCR7(+) cells peaked 8 mice. No...
Recently, both living and deceased organ donation rates have hit a plateau, despite increases in need for viable organs. One approach to improve rate is public education policy; thus, it necessary understand the information receiving regarding donation. We hypothesized that primetime medical dramas portray transplantation negative manner. compiled data on all drama episodes with transplant themes from November 2008 through June 2010 assessed depictions of donors candidates. Positive thematic...
Limited research exists on the influence of social determinants health (SDOH) outcomes in pediatric patients with advanced heart failure receiving mechanical circulatory support.