A5065899798- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Vagus Nerve Stimulation Research
- Heart rate and cardiovascular health
- Cardiovascular Disease and Adiposity
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Polyomavirus and related diseases
- Cutaneous lymphoproliferative disorders research
- Cerebrovascular and genetic disorders
- Poisoning and overdose treatments
- Adenosine and Purinergic Signaling
- Tumors and Oncological Cases
- Inflammatory Myopathies and Dermatomyositis
- Pharmacological Receptor Mechanisms and Effects
- Brucella: diagnosis, epidemiology, treatment
- Autoimmune Bullous Skin Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Airway Management and Intubation Techniques
- Dermatologic Treatments and Research
- Urticaria and Related Conditions
- Clinical Nutrition and Gastroenterology
- Eosinophilic Disorders and Syndromes
- Biochemical effects in animals
- Body Contouring and Surgery
The University of Texas Health Science Center at San Antonio
2018-2024
The University of Texas at San Antonio
2020-2024
Institute for Neurodegenerative Disorders
2024
Center for Clinical and Cosmetic Research
2023
San Antonio Uniformed Services Health Education Consortium
2023
Bay Area Medical Center
2023
The University of Texas Health Science Center at Houston
2019-2023
Audie L. Murphy Memorial VA Hospital
2022
Integrative Health Technologies (United States)
2019
St. Mary's University, Texas
2016
The dorsal motor nucleus of the vagus (DMV) contains preganglionic neurons important in regulation glucose homeostasis and gastrointestinal function. Despite role sex these processes, few studies examine and/or ovarian cycle synaptic neurotransmission to DMV. Since GABAergic is critical normal DMV function, present study used vitro whole cell patch-clamping investigate whether differences exist neurons. It additionally investigated plays a those differences. frequency phasic GABA
High fat diet (HFD) promotes cardiovascular disease and blunted cardiac vagal regulation. Temporal onset of loss control its underlying mechanism are presently unclear. We tested our hypothesis that reduced central regulation occurs early after HFD contributes to poor using testing paired with pharmacology in mice, molecular biology, a novel bi-transgenic mouse line. Results show HFD, compared normal (NFD), significantly cardio/pulmonary chemoreflex bradycardic responses 15 days, extending...
Abstract Background Recent research suggests that soluble pathogenic tau accumulates in the brain microvasculature of patients with Alzheimer’s Disease (AD) and primary tauopathies, driving cerebrovascular impairments further accumulation. However, little is known about interplay these processes before dementia onset. In present study, we investigated association between free water (FW), an early biomarker cerebral small vessel disease, accumulation rhinal, entorhinal, inferotemporal...
Abstract Background: Traumatic brain injury (TBI) remains one of the greatest public health concerns with increasing morbidity and mortality rates worldwide. Our group reported stimulation astrocyte mitochondrial metabolism by P2Y1 receptor agonists significantly reduced cerebral edema reactive gliosis in a TBI model. Subsequent data on pharmacokinetics (PK) rapid these compounds suggested neuroprotection was likely mediated metabolite, AST-004, which binding indicated an adenosine A3 (A3R)...
Objective Heart failure is the leading cause of death and disability in world, with 7.4 million deaths occurring 2012 alone. Despite marked improvements nearly every cardiovascular disease including heart attacks, has uniquely increased prevalence lacks therapeutic options targeting progressive fibrotic response that commonly characterizes its pathogenesis. Much like compensatory process seen scarring wounded skin, responds to ischemia, hypertension, common genetic mutations by undergoing...
Abstract Sarcoidosis is a granulomatous disorder that characterized by the development of noncaseating granulomas affecting multiple organ systems, most commonly lungs and lymph nodes body. Aside from these sarcoidosis can also affect skin, eyes, central nervous system, liver, heart, kidneys, musculoskeletal system. We present patient with subcutaneous sarcoidosis, known as Darier-Roussy disease, without extracutaneous findings. Patients may benefit topical or intralesional steroids for...
Cardiac vagal motor output is generated by brainstem cardiac motorneurons (CVNs) that send axonal projections, through the vagus nerve, to ganglia. CVNs have a well-established cardioinhibitory influence reductions in heart rate (HR) and studies using vagotomy confirm drive originates CVNs. can be found two regions: nucleus ambiguus (NA) dorsal of (DMV). Although role NA (CVN ) widely accepted, effects DMV on HR regulation controversial. The present study aims provide evidence CVN existence...
Summary Cardiovagal neurons (CVNs) innervate cardiac ganglia through the vagus nerve to control function. Although cardioinhibitory role of CVNs in nucleus ambiguus (CVN NA ) is well established, nature and functionality dorsal motor DMV less clear. We therefore aimed characterize CVN anatomically, physiologically, functionally. Optogenetically activating cholinergic resulted robust bradycardia peripheral muscarinic (parasympathetic) nicotinic (ganglionic) acetylcholine receptors, but not...
Neurons in the dorsal motor nucleus of vagus (DMV) comprise preganglionic parasympathetic output to much viscera and critically contribute autonomic regulation energy homeostasis. Gamma‐aminobutyric acid (GABA) is main inhibitory neurotransmitter mediating both tonic (extrasynaptic) phasic (synaptic) inhibition DMV. A small body evidence suggests that GABA receptor activity throughout brain exhibits sexually dimorphic regulation. Some differences between two sexes may arise through estrous...
The pathological link between consumption of fat and the development cardiovascular disease (CVD) has long been established. Still, obesity‐independent mechanisms through which a high diet (HFD) contributes to pathogenesis CVDs like cardiac arrhythmias remain elusive. A wealth preclinical, clinical, epidemiological data conclusively linked autonomic nervous system dysfunction—characterized by potentiation sympathetic activity, decrease in parasympathetic vagal tone—to broad spectrum...
Central vagal circuitry plays a key role in cardioinhibition and is critical to cardiac homeostasis. Long-term high fat diet (HFD) associated with decreased drive, which linked increased cardiovascular morbidity mortality. However, recent evidence suggests that HFD elicits changes central circuits during early consumption (days). This study tested the hypothesis regulation contributes poor first two weeks of HFD. C57/Bl6 mice were examined for autonomic HR both at rest reflex challenges...
The DMV is critical in the maintenance of gastrointestinal (GI) function and metabolism through its axonal projections to subdiaphragmatic organs. However, there a subpopulation choline acetyltransferase (ChAT) positive neurons that send cardiac tissue. Given their anatomical apposition nuclei regulating GI metabolic function, it likely vagal motorneurons (CVNs) are sensitive nutrient signals such as high fat diet (HFD). We hypothesized HFD exposure for 15 days modulates electrophysiological...
We report a case of tophaceous gout occurring in Hispanic 69-year-old immunocompetent man. The patient presented with 0.8 cm pink, purple, and brown dome-shaped papule on the right superior helix ear. lesion was tender to palpitation. A deep shave biopsy performed histological findings demonstrated pseudoepitheliomatous hyperplasia overlying large dermal deposits hyalinized feathery material surrounded by mild granulomatous inflammation. This finding supported diagnosis rather than clinical...
Skin toxicity, or folliculitis, is the most common adverse side effect resulting from use of antineoplastic signal transduction inhibitors like epidermal growth factor receptor (EGFRI) panitumumab and poziotinib. This condition takes a toll on patient’s quality life can affect up to 90% patients. Moreover, it one primary contributing factors decision discontinue therapy, thus highlighting need for better dermatologic interventions help mitigate effects EGFRI treatment. We present case...
Background: Fluid therapy in perioperative cesarean section remains a debated topic. Its purpose is to maintain or restore circulating blood volume and may affect the plasma acid-base balance of mother neonatal. Therefore, aim this study was compare effects Normal saline with Ringer's lactate serum on status neonate elective section. Methods: forty-eight healthy term parturient women scheduled for were randomly divided into two groups (24 patients each). The first group received second...
We report a case of erythema annulare centrifugum-like psoriasis occurring in 44-year-old female. The patient presented with annular erythematous plaques trailing collarette scales affecting the elbows and antecubital fossae, which are consistent clinical diagnosis centrifugum (EAC). Given presence classical features EAC, this was notable due to biopsy findings, revealed classic histologic changes psoriasis. This finding supports represents rare presentation acute Treatment topical...