A5064417231- Organ Transplantation Techniques and Outcomes
- Cardiac Ischemia and Reperfusion
- Diet and metabolism studies
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Organ Donation and Transplantation
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Hydrogen's biological and therapeutic effects
- Racial and Ethnic Identity Research
- Clinical Nutrition and Gastroenterology
- Cardiac Arrhythmias and Treatments
- Cultural Differences and Values
- Fuel Cells and Related Materials
- Poisoning and overdose treatments
- Neuroscience and Neuropharmacology Research
- Ultrasound and Hyperthermia Applications
- Organ and Tissue Transplantation Research
- Veterinary Pharmacology and Anesthesia
- Mass Spectrometry Techniques and Applications
- Emotional Intelligence and Performance
- Anesthesia and Neurotoxicity Research
- Advanced MRI Techniques and Applications
Perfusion Solution (United States)
2022-2024
The University of Texas Health Science Center at San Antonio
2018-2022
ORCID
2022
Hollins University
2022
May Institute
2022
The University of Texas at San Antonio
2007
Nearly three million people in the USA suffer traumatic brain injury (TBI) yearly; however, there are no pre- or post-TBI treatment options available. KCNQ2-5 voltage-gated K + channels underlie neuronal “M current”, which plays a dominant role regulation of excitability. Our strategy towards prevention TBI-induced damage is predicated on suggested hyper-excitability neurons induced by TBIs, and decrease excitation upon pharmacological augmentation M/KCNQ currents. Seizures very common after...
Introduction Heart transplant remains the gold standard treatment for patients with advanced heart failure. However, list of waiting a continues to increase. We have developed portable hypothermic oxygenated machine perfusion device, VP.S ENCORE®, extend allowable preservation time. The purpose this study was test efficacy VP.S. ENCORE® using deceased donors derived hearts. Methods Hearts from brain-dead not utilized ( n = 11) were offered research Texas Organ Sharing Alliance (TOSA), South...
Neuroticism is a risk factor for mood and anxiety disorders strong predictor of subjective stress in non-Hispanics. This study examined neuroticism as acculturative 122 Mexican American college students. was measured using the Revised Extroversion Openness Personality Inventory (NEO-PI-R), Hispanic Stress (HSI). Results hierarchical regression analyses showed that overall facets depression, vulnerability, anger and/or hostility significantly predicted stress. The association between greater...
Drugs that induce reversible slowing of metabolic and physiological processes would have great value for organ preservation, especially organs with high susceptibility to hypoxia-reperfusion injury, such as the heart. Using whole-organism screening metabolism, mobility, development in Xenopus , we identified an existing drug, SNC80, rapidly reversibly slows biochemical activities while preserving cell tissue viability. Although SNC80 was developed a delta opioid receptor activator,...
BACKGROUND The two approaches to vascularized tissue machine perfusion use either the open (nonpressurized) or closed (pressurized) system. Most studies describing isolated limb preservation rely on systems and report edema exceeding 40% after 12 14 hours of preservation. A variant places perfusate into a reservoir atmosphere. It is hypothesized that pressure, acting as transmural has advantage reducing formation by counteracting hydrostatic pressure gradient from pressure. This...
Drugs that induce reversible slowing of metabolic and physiological processes would have great value for organ preservation, especially organs with high susceptibility to hypoxia-reperfusion injury, such as the heart. Using whole-organism screening metabolism, mobility, development in Xenopus , we identified an existing drug, SNC80, rapidly reversibly slows biochemical activities while preserving cell tissue viability. Although SNC80 was developed a delta opioid receptor activator,...
ABSTRACT Drugs that induce reversible slowing of metabolic and physiological processes would have great value for organ preservation, especially organs with high susceptibility to hypoxia-reperfusion injury, such as the heart. Using whole-organism screening metabolism, mobility, development in Xenopus , we identified an existing drug, SNC80, rapidly reversibly slows biochemical activities while preserving cell tissue viability. Although SNC80 was developed a delta opioid receptor activator,...
Purpose: Heart transplantation is the gold standard therapy for patients with end-stage heart failure. However, supply of donor hearts does not meet demand, and many die on waitlist. The purpose this study was to test efficacy a novel machine perfusion device, VP.S ENCORE® cardiac preservation in preserving porcine conditioned biostasis-inducing compound (WC1) during prolonged 6-8 hour perfusion. Methods: Isolated were recovered under anesthesia. Following cannulation, placed device...