A5076499873- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Gene expression and cancer classification
- RNA Research and Splicing
- Plant biochemistry and biosynthesis
- Pancreatic and Hepatic Oncology Research
- PARP inhibition in cancer therapy
- Extracellular vesicles in disease
- Lichen and fungal ecology
- BRCA gene mutations in cancer
- Neurogenesis and neuroplasticity mechanisms
- Plant Pathogens and Fungal Diseases
- Circular RNAs in diseases
- interferon and immune responses
- Surgical Sutures and Adhesives
- FOXO transcription factor regulation
- Methane Hydrates and Related Phenomena
- Microbial Community Ecology and Physiology
- Genetics, Bioinformatics, and Biomedical Research
- Facial Rejuvenation and Surgery Techniques
University of Southern Denmark
2024-2025
Queen's University Belfast
2020-2022
Government of Gujarat
2015-2021
Stanford University
2015
Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged critical players tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes poorly understood. Here, we show that expansion aged Treg does not rescue age-associated remyelination impairment due an intrinsically...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype, characterized by extensive intratumoral heterogeneity, high metastasis, and chemoresistance, leading to poor clinical outcomes. Despite progress, mechanistic basis of these behaviors remains poorly understood. Using single-cell spatial transcriptome analysis, here we discovered basal epithelial subpopulations located within stroma that exhibit chemoresistance characteristics. The are defined distinct signature...
Abstract Metastasis remains a leading cause of cancer-related mortality, irrespective the primary tumour origin. However, core gene regulatory program governing distinct stages metastasis across cancers poorly understood. We investigate this through single-cell transcriptome analysis encompassing over two hundred patients with metastatic and non-metastatic tumours six cancer types. Our revealed prognostic signature that provides insights into intricate cellular dynamics networks driving...
Abstract DNA methyltransferase and poly (ADP-ribose) polymerase inhibitors (DNMTis, PARPis) induce a stimulator of interferon genes (STING)-dependent pathogen mimicry response (PMR) in ovarian other cancers. Here, we showed that combining DNMTis PARPis upregulates expression the nucleic-acid sensor NFX1-type zinc finger-containing 1 protein (ZNFX1). ZNFX1 mediated induction PMR mitochondria, serving as gateway for STING-dependent interferon/inflammasome signaling. Loss cancer cells promoted...
<p>Supplementary Figures</p>
<div>Abstract<p>DNA methyltransferase (DNMT) and PARP inhibitors induce a stimulator of IFN gene–dependent pathogen mimicry response (PMR) in ovarian other cancers. In this study, we showed that combining DNMT upregulates expression the nucleic acid sensor NFX1-type zinc finger–containing 1 (ZNFX1) protein. ZNFX1 mediated induction PMR mitochondria, serving as gateway for IFN/inflammasome signaling. Loss cancer cells promoted proliferation spheroid formation <i>in...
// Inayatullah Shaikh 1 , Afzal Ansari Garima Ayachit Monika Gandhi Priyanka Sharma Shivarudrappa Bhairappanavar Chaitanya G. Joshi and Jayashankar Das Gujarat Biotechnology Research Centre (GBRC), Department of Science Technology (DST), Government Gujarat, Gandhinagar 382011, India Correspondence to: Das, email: jayshankardas@gmail.com jd2-gbrc@gujarat.gov.in Keywords: tobacco; head neck squamous cell carcinoma (HNSCC); differentially expressed genes; hub gene; miRNA Received: June 14, 2019...
Abstract Gymnema sylvestre is a highly valuable medicinal plant in traditional Indian system of medicine and used many polyherbal formulations especially treating diabetes. However, the lack genomic resources has impeded its research at molecular level. The present study investigated functional gene profile G. via RNA sequencing technology. de novo assembly 88.9 million high quality reads yielded 23,126 unigenes, which 18116 were annotated against databases such as NCBI nr database, ontology...
Background Breast and ovarian cancers are the most prevalent one of leading causes death in Indian women. The healthcare burden breast rise mortality rate worrying stress need for early detection treatment. Methods We performed amplicon sequencing 144 cases who had breast/ovarian cancer disease (total 137 patients seven tested BRCA1/2 carrier) Using our custom designed gene panel consisting 14 genes, that associated with high to moderate risk cancers. Variants were called using Torrent...
The multistep process of epithelial-to-mesenchymal transition (EMT), whereby static epithelial cells become migratory mesenchymal cells, plays a critical role during various developmental contexts, wound healing, and pathological conditions such as cancer metastasis. Despite the established function basic helix-loop-helix (bHLH) transcription factors (TFs) in cell fate determination, only few have been examined for their EMT. Here, using transcriptome analysis distinct stages stepwise...
Abstract DNA methyltransferase and poly(ADP-ribose) polymerase inhibitors (DNMTis, PARPis) induce a stimulator of interferon (IFN) genes (STING)-dependent pathogen mimicry response (PMR) in ovarian (OC) other cancers. We now show that combining DNMTis PARPis upregulates expression little-studied nucleic-acid sensor, NFX1-type zinc finger-containing 1 protein (ZNFX1). demonstrate ZNFX1 is novel master regulator for PMR induction mitochondria, serving as gateway STING-dependent PMR. In patient...
AMERICAN SOCIETY OF PLASTIC SURGEONS & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK