A5075133137- Hormonal and reproductive studies
- Cardiac Ischemia and Reperfusion
- Viral Infections and Immunology Research
- Human Health and Disease
- Nutrition, Genetics, and Disease
- Sexual Differentiation and Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Adrenal and Paraganglionic Tumors
- Vascular anomalies and interventions
- Cancer, Hypoxia, and Metabolism
- Pharmacology and Obesity Treatment
- Rabies epidemiology and control
- Laser Applications in Dentistry and Medicine
- Sexual function and dysfunction studies
- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Cardiac tumors and thrombi
- Thyroid Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Doping in Sports
- Forensic Toxicology and Drug Analysis
- Signaling Pathways in Disease
- Growth Hormone and Insulin-like Growth Factors
- Cardiac electrophysiology and arrhythmias
Wroclaw Medical University
2006-2024
University of Wrocław
2006-2012
<h3>Objective</h3> To investigate whether alterations in the phosphorylation status of matrix metalloproteinase 2 (MMP-2) heart may be protective setting ischaemia–reperfusion (IR) injury. <h3>Design</h3> In-vitro function and biochemical research study. <h3>Setting</h3> University basic science laboratory. <h3>Interventions</h3> Male Sprague–Dawley rats, weighing 250–350 g. Isolated rat hearts were perfused at constant pressure either aerobically for 75 min or subjected to 20 global,...
Aims: Acute myocarditis is a potentially lethal inflammatory heart disease that frequently precedes the development of dilated cardiomyopathy and subsequent failure. At present, there no effective standardized therapy for acute myocarditis, besides optimal care failure arrhythmias in accordance with evidence-based guidelines specific etiology-driven infectious myocarditis. Carvedilol has been shown to be cardioprotective by reducing cardiac pro-inflammatory cytokines present oxidative stress...
Matrix metalloproteinase 2 (MMP-2) is activated in hearts upon ischemia-reperfusion (IR) injury and cleaves sarcomeric proteins. It was shown that carvedilol nebivolol reduced the activity of different MMPs. Hence, we hypothesized they could reduce MMPs activation myocytes, therefore, protect against cardiac contractile dysfunction related with IR injury. Isolated rat were subjected to either control aerobic perfusion or injury: 25 min perfusion, followed by 20 global, no-flow ischemia,...
Background: One factor that may negatively impact male reproductive health is the illegal use of testosterone and anabolic–androgenic steroids. This study aimed to evaluate prevalence in recreational athletes, as well factors associated with its use, determine profile a person using testosterone. Methods: A cross-sectional analysis data from an anonymous, online questionnaire men recruited gyms, randomly selected Wrocław, Poland, has been performed. The minimal sample size was evaluated...
The present study investigated whether Rho-associated protein kinase (RhoA/ROCK) signaling pathway inhibitor simvastatin inhibits matrix metalloproteinase 2 (MMP-2) activity in a rat ischemia-reperfusion injury (I/Ri) model by inhibiting the RhoA/ROCK and reducing MMP-2 mRNA levels. Isolated hearts were subjected to aerobic perfusion or I/Ri control. effect of was assessed I/Ri. We determined cardiac mechanical function, content RhoA, phosphorylated myosin light chain subunit 1...
Acute myocarditis often progresses to heart failure because there is no effective, etiology-targeted therapy of this disease. Simvastatin has been shown be cardioprotective by decreasing matrix metalloproteinases' (MMPs) activity. The study was designed determine whether simvastatin inhibits MMPs activity, decreases the severity inflammation and contractile dysfunction in experimental autoimmune (EAM).Simvastatin (3 or 30 mg/kg/day) given rats with EAM gastric gavage for 21 days. Then...
Summary Relative energy deficiency in sport occurs athletes who have limited availability. Its typical features include reversible suppression of the hypothalamic–pituitary–gonadal axis. In addition, it may be accompanied by hepatic resistance to growth hormone, leading a decrease insulin-like factor 1 and dysregulation hypothalamic–pituitary–thyroid We present clinical case 33-year-old athlete previously treated effectively for hypothyroidism, presented with low thyroid-stimulating free...
The use of specific medicine up to several months before a doping control is not be reported on the form, while drug could then still detectable in urine case very slow elimination. It may lead positive test result. For example, dorzolamide, carbonic anhydrase inhibitor for topical ophthalmic application, has elimination rate via renal route (half-life > 4 months). This substance can source unintended anti-doping rule violations.
Many studies have proven the involvement of RhoA/ROCK pathway in autoimmune and cardiovascular diseases beneficial effects its downregulation. Here, we examined whether effect simvastatin on experimental myocarditis (EAM) may be through targeting Ras homolog family member A/Rho-associated coiled-coil containing kinases (RhoA/ROCK) previously shown downregulation metalloproteinase 9 (MMP-9) could associated with MLC phosphorylation. Two doses were administered to rats by gastric gavage for 3...
Background/Objectives: Illegal anabolic-androgenic steroids are a significant lifestyle factor in infertility. The aim of our study was to analyze clinical cases resulting from their use for frequency, geographical location, dynamics, substances used, the age and gender users, types complications. Methods: Publications were obtained by searching PubMed following terms: ‘anabolic-androgenic steroids’ ‘clinical case’. 1973 2022 qualified analysis. Results: An increasing trend number steroids,...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Skrzypiec-Spring M, Krzywański J, Karlikowska-Skwarnik et al. Pertussis outbreak in Polish shooters with adverse event analysis. Biology of Sport. 2017;34(3):243-248. doi:10.5114/biolsport.2017.66001. APA Skrzypiec-Spring, M., Krzywański, J., Karlikowska-Skwarnik, Pokrywka, A., Krysztofiak, H., & Nitsch-Osuch, A. (2017). Sport, 34(3), 243-248. https://doi.org/10.5114/biolsport.2017.66001 Chicago Monika,...
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