A5010498479- Genomics and Chromatin Dynamics
- Insect symbiosis and bacterial influences
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Coronary Artery Anomalies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect Resistance and Genetics
- Congenital Heart Disease Studies
- Animal Genetics and Reproduction
- Parasite Biology and Host Interactions
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Cancer-related gene regulation
- Invertebrate Immune Response Mechanisms
Umeå University
2016-2018
Polycomb Group (PcG) proteins are epigenetic repressors essential for control of development and cell differentiation. They form multiple complexes which PRC1 PRC2 evolutionary conserved obligatory repression. The targeting is poorly understood was proposed to be hierarchical involve tri-methylation histone H3 (H3K27me3) and/or monoubiquitylation H2A (H2AK118ub). Here, we present a strict test this hypothesis using the Drosophila model. We discover that neither H3K27me3 nor H2AK118ub...
Environmental perturbations induce transcriptional changes, some of which may be inherited even in the absence initial stimulus. Previous studies have focused on transfers through germline although microbiota is also passed to offspring. Thus, we inspected involvement gut microbiome transgenerational inheritance environmental exposures Drosophila melanogaster . We grew flies cold versus control temperatures and compared their patterns both conditions as well F2 temperature, while controlled...
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Ventricular dysfunction and cardiac arrhythmias are well-documented complications in patients with repaired TOF. Whether intrinsic abnormalities exist TOF cardiomyocytes unknown. We establish human induced pluripotent stem cells (hiPSCs) from without DiGeorge (DG) syndrome, latter being commonly associated syndromal association TOF-DG hiPSC-derived (hiPSC-CMs) show impaired ventricular specification,...