A5074442515- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Blood groups and transfusion
- Hemophilia Treatment and Research
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Complement system in diseases
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Cancer-related gene regulation
- Rabies epidemiology and control
- Diabetes and associated disorders
- Blood properties and coagulation
- Herpesvirus Infections and Treatments
- RNA Research and Splicing
- Blood Coagulation and Thrombosis Mechanisms
- Genetic Syndromes and Imprinting
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Poxvirus research and outbreaks
Shanghai Jiao Tong University
2023-2025
Ruijin Hospital
2022-2025
Shanghai Clinical Research Center
2023
Shanghai Institute of Hematology
2022
Background Drug-induced immune hemolytic anemia (DIIHA) is a rare but serious condition, with an estimated incidence of one in 100,000 cases, associated various antibiotics. This study reports on case ceftizoxime-induced hemolysis observed patient China. Case description A Chinese diagnosed malignant rectal cancer underwent antimicrobial therapy after laparoscopic partial recto-sigmoid resection (L-Dixon). After receiving four doses ceftizoxime, the developed symptoms including rash, itchy...
ABSTRACT The HLA‐DPB1*1498:01 allele differs from HLA‐DPB1*02:02:01:01 by a single non‐synonymous nucleotide change in exon 4.
ABSTRACT The HLA‐B*15:11:08 allele differs from HLA‐B*15:11:01 by a single non‐synonymous nucleotide change in exon 4.
HLA‐B*46:01:42 differs from HLA‐B*46:01:01:01 by one nucleotide in exon 5.
Summary Hereditary factor VII (FVII) deficiency is a rare recessive bleeding disorder with an estimated prevalence of 1/500 000. We had investigated 50 unrelated Chinese patients FVII and identified, in total, 25 mutations, including 18 missense mutations 5 splicing on the F7 gene. The nucleotide transition c.1224T>G (p.His408Gln) exon 9 constitutes hotspot mutation, 19 harbouring this genetic variance. Few were homozygous or compound heterozygous for deleterious such as non‐sense large...
There is growing evidence that synonymous codon variants (SCVs) can cause disease through the disruption of different processes protein production. The aim study to investigate whether 14 SCVs reported in F9 variant database were pathogenic causes hemophilia B. impacts on splicing and expression detected using a combination silico prediction, vitro minigene assay cell detection. transcripts identified quantified by co-amplification fluorescent PCR. mechanism was verified modified pU1snRNA...
HLA‐A*30:01:24 differs from HLA‐A*30:01:01:01 by one nucleotide in exon 3.
HLA‐A*11:448 differs from HLA‐A*11:01:01:01 by one nucleotide in exon 5.
The dysfunction of the ABO glycosyltransferase (GT) enzyme, which is caused by mutations in gene, can lead to weak phenotypes. In this study, we have discovered a novel subgroup allele and investigated underlying mechanism causing its A