A5055136405- Diet and metabolism studies
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Renal function and acid-base balance
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Nitric Oxide and Endothelin Effects
- Advanced Glycation End Products research
- Stress Responses and Cortisol
- Metabolomics and Mass Spectrometry Studies
- Nutrition and Health in Aging
- Air Quality and Health Impacts
- Alcohol Consumption and Health Effects
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- HER2/EGFR in Cancer Research
- Dietary Effects on Health
- Glutathione Transferases and Polymorphisms
- Birth, Development, and Health
- Sulfur Compounds in Biology
- Redox biology and oxidative stress
- Occupational and environmental lung diseases
- Biochemical effects in animals
- Sleep and related disorders
University of California, San Diego
2019-2024
San Diego State University
2018-2024
Moores Cancer Center
2019-2020
University of Cincinnati
2009-2016
University of Cincinnati Medical Center
2009-2016
Ningbo Dahongying University
2016
Society of Environmental Toxicology and Chemistry
2013
The Ohio State University
2012
University of Kentucky
2012
Harvard University
2004-2009
OBJECTIVE—Coffee consumption is associated with reduced risk of type 2 diabetes, but the mechanism not clearly understood. Elevated C-peptide, as a marker insulin secretion, has been linked to insulin-resistant diabetes. In this study, we examined caffeinated and decaffeinated coffee total caffeine in relation concentrations plasma C-peptide. RESEARCH DESIGN AND METHODS—Plasma C-peptide were measured cross-sectional setting among 2,112 healthy women from Nurses’ Health Study I who provided...
Despite the fact that most breast cancer patients have estrogen receptor (ER) α-positive tumors, up to 50% of are or soon develop resistance endocrine therapy. It is recognized HER2 activation one major mechanisms contributing resistance. In this study, we report ER coactivator MED1 a novel cross-talk point for and ERα pathways. Tissue microarray analysis human cancers revealed expression positively correlates strongly with status tumors. was highly phosphorylated, in HER2-dependent manner,...
Observational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD co-morbid conditions. We investigated the genetic contributions PTSD, 18 diseases, 3 immune/inflammatory biomarkers. Univariate MiXeR was used contrast architectures of phenotypes. Genetic correlations were estimated using linkage disequilibrium score...
Metabolic acidosis can lead to inflammation, tissue damage, and cancer metastasis. Dietary acid load contributes metabolic if endogenous acid-base balance is not properly regulated. Breast survivors have reduced capacities adjust their balance; yet, the associations between dietary inflammation hyperglycemia been examined among them. We analyzed data collected from 3042 breast enrolled in Women's Healthy Eating Living (WHEL) Study who had provided detailed intakes measurements of plasma...
Cannabis use is increasing and cannabis typically consumed by smoking. This study explored how indoor secondhand smoke (SCS) was associated with child health. As part of a larger trial, air particle monitors were placed in 298 homes families at least one cigarette smoker under 14 years old San Diego County, California. Assessment included past 7-day use, the youngest child's exposure to smoke, 5 smoke-related past-year health outcomes: emergency department for coughing/difficulty breathing;...
Currently lacking are stable and easily measured biomarkers that can reflect oxidative stress in humans. Fluorescent oxidation products may fulfill all three of these criteria. Fasting plasma levels fluorescent were 286 controls a study coronary heart disease among US men aged 47–81 years; the concluded 2006. Other also measured, cardiovascular risk factors such as smoking, hypertension, age, physical activity assessed by questionnaire. Indicators stress, including reduced renal function,...
ABSTRACT Human studies suggest that oxidative stress is a risk factor for osteoporosis, but its relationship with fracture poorly understood. The purpose of the present study was to investigate association between biomarkers and hip in postmenopausal women. We conducted prospective Nurses' Health Study among 996 women aged 60 years or older at baseline blood collection 1989–1990. Plasma fluorescent oxidation products (FlOPs) were measured three excitation/emission wavelengths (360/420 nm...
Although replacement of dietary saturated fat with monounsaturated and polyunsaturated fatty acids (MUFA PUFA) has been advocated for the reduction cardiovascular disease risk, diets high in PUFA could increase low density lipoprotein (LDL) susceptibility to oxidation, potentially contributing pathology atherosclerosis. To investigate this possibility, 15 postmenopausal women a blinded crossover trial consumed g sunflower oil (SU) providing 12.3 g/day oleate, safflower (SA) 10.5 linoleate,...
Oxidative stress is hypothesized to play an important role in a variety of chronic diseases, but the short-term and long-term stability measurements biomarkers related oxidative remains unclear. The objective this study was evaluate malondialdehyde (MDA), F2-isoprostanes, fluorescent oxidation products blood stored on ice within 36 hours until processing. Whole samples from six healthy women were processed at 0, 24, after being ice. MDA measured by thiobarbituric acid-reactive substances...
Fluorescent oxidation products in plasma are stable with routine blood collection methods and reflect food, animals, vitro.Whether fluorescent predict future coronary heart disease has not been established.Among US men without cardiovascular who provided specimens 1994 the Health Professionals Follow-up Study, authors confirmed 266 incident nonfatal myocardial infarction or fatal endpoints during 6 years of follow-up.Using a nested case-control design, they measured baseline levels...
Background Oxidative stress is implicated in the etiology of coronary heart disease ( CHD ). New measures to capture oxidative are warranted. Fluorescent oxidation products FlOP s) can be measured plasma and have been shown reflect levels predict risk men over 6 years follow‐up. The objective this study determine whether s associated with women an extended follow‐up period. Methods Results We by spectrofluorometer a nested case–control within N urses' H ealth S tudy, baseline blood...
<b><i>Background/Aims:</i></b> Plasma fluorescent oxidation products (FLOP) constitute a<b> </b>stable and easily measured biomarker of cumulative oxidative stress. However, their association with chronic kidney disease (CKD) has not been studied. <b><i>Methods:</i></b> We examined the FLOP CKD in 201 patients controls without from community. was defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73...
Erythrocyte antioxidant enzymes are major circulating in the oxidative stress defense system. Few prospective studies have assessed association between these and risk of coronary heart disease (CHD) generally healthy adults. We conducted a nested case-control study CHD among 32,826 women at baseline with 15 years follow-up from 1989 to 2004 Nurses' Health Study. investigated erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities CHD. A total 365 cases...
Current dietary guidelines do not consider cancer survivors’ and past smokers’ low capacity to regulate their acid–base balance. People with a balance are more susceptible acid-producing diets. We studied cohort of 2950 early stage breast survivors who provided information at baseline during follow-up. assessed the intakes diets via two commonly used acid load scores: potential renal (PRAL) net endogenous production (NEAP). smoking intensity by pack-years smoking. After an average 7.3 years...
The incidence of depression is two-to-three times higher in cancer survivors than the general population. Acid-producing diets may play important roles development depression. Cancer are more susceptible to acid-producing diets, yet few prospective studies have investigated association with among breast survivors. We leveraged a large cohort 2975 early stage survivors, which collected detailed dietary data via 24-h recalls. Potential renal acid load (PRAL) and net endogenous production...
Healthy diets may lower oxidative stress and risk of chronic diseases. However, no previous studies examined associations between diet fluorescent oxidation products (FlOP), a global marker stress. We evaluated healthy eating patterns (Alternative Eating Index (AHEI), Dietary Approach to Stop Hypertension (DASH), Alternate Mediterranean Diet (aMED)) FlOP, measured at three excitation/emission wavelengths (FlOP_360, FlOP_320, FlOP_400) from 2021 blood samples collected 1688 women within the...
Non-alcoholic fatty liver disease (NAFLD) is common among 30% of American adults. Former and current smokers are at higher risk for NAFLD compared to never smokers. The ratio urine caffeine metabolites intake-namely, metabolite indices-has previously been used as a proxy CYP1A2 activity, which one the main metabolizing enzymes. activity associated with progression. No studies our knowledge have examined associations enzymes, smoking intensity, secondhand smoke (SES) (using indices) across...
The purpose of this study was to examine the independent and joint associations acid-producing diets depressive symptoms with physical health among breast cancer survivors. We studied a cohort 2944 early stage survivors who provided dietary, health, demographic, lifestyle information at baseline, year 1, 4. assessed intakes via two commonly used dietary acid load scores: potential renal (PRAL) net endogenous production (NEAP). Physical measured using Rand 36-Item Short Form Health Survey...