A5060734344- Anesthesia and Pain Management
- Neuroendocrine Tumor Research Advances
- Intraocular Surgery and Lenses
- Neuroblastoma Research and Treatments
- Peripheral Nerve Disorders
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Nerve Injury and Rehabilitation
- Orthopedic Surgery and Rehabilitation
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Spine and Intervertebral Disc Pathology
- Botulinum Toxin and Related Neurological Disorders
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Muscle and Compartmental Disorders
- Advanced Biosensing Techniques and Applications
- Abdominal vascular conditions and treatments
- Immunotherapy and Immune Responses
- Soft tissue tumor case studies
- Mechanical Circulatory Support Devices
Philipps University of Marburg
2008-2020
Hamm-Lippstadt University of Applied Sciences
2016-2019
Universitätsklinikum Gießen und Marburg
2006-2014
Background and Aim Chemotherapy with streptozocin (STZ) in combination 5-FU or doxorubicin (Dox) represents a standard of care for patients metastatic pancreatic neuroendocrine neoplasms (pNEN). However, predictive markers patient selection are still missing. The aim this study was retrospective evaluation the clinicopathological characteristics pNEN receiving STZ-based chemotherapies to identify prognostic markers. Patients Methods We retrospectively analyzed 77 treated at our center...
In this study, we determined whether needle advancement during needle-nerve contact (forced contact) is associated with a higher risk of nerve injury compared without (nonforced contact).In 8 anesthetized pigs, the brachial plexus nerves underwent forced (0.15 Newton) or nonforced (0.0 penetration. The grade was histologically assessed using an objective score ranging from 0 (no injury) to 4 (severe injury).Sixty-nine nerves, including controls, were examined. Histology revealed significant...
Background. Nerve stimulation can facilitate correct needle placement in peripheral regional anesthesia. The aim of this study was to determine whether the high threshold current is associated with reduced nerve injury due fewer needle-nerve contacts compared low current. Methods. In anaesthetized pigs, thirty-two nerves brachial plexus underwent at (0.2 mA) or (1.0 mA). occurrence contact recorded. After 48 hours, were analyzed for histological changes. scored ranging from 0 (no injury) 4...
Purpose Genome-wide analyses revealed basal and luminal subtypes of urothelial carcinomas the bladder. It is unknown if this subtyping can also be applied to upper tract carcinomas. Materials methods Tumor samples from 222 patients with who were treated radical nephroureterectomy analyzed for expression seven basal/luminal immunohistochemical markers (CK5, EGFR, CD44, CK20, p63, GATA3, FOXA1). Results Hierarchical clustering a basal-like subtype (enrichment CK5, EGFR CD44) in 23.9%...
Continuous peripheral nerve blocks typically are performed with a "through-the-needle technique" and require needles an inner diameter allowing catheter placement. In case of direct needle-nerve contact, the pencil-point needletip is currently considered less traumatic than other needle configurations. this study we determined whether puncture associated fewer injuries in comparison Tuohy needles.In 6 anesthetized pigs brachial plexus were exposed bilaterally. Up to 8 nerves underwent or...
Background: The purpose of this study was to determine whether the application high stimulation current thresholds (SCT) leads a distant needle nerve proximity (NNP) compared with low SCT during localization for regional anaesthesia in pigs. Methods: A minimal motor response femoral or brachial plexus nerves 16 anaesthetized pigs triggered either by (0.01–0.3 mA) (0.8–1.0 random order. After eliciting predetermined SCT, synthetic resin injected via needle. postmortem dissection injection...
Background: In the case of needle nerve contact during peripheral blocks, pencil point needles are considered less traumatic compared with bevelled needles. However, there not enough data to prove this notion. Therefore, aim study was challenge hypothesis that perforation short is associated major damage Methods: five anaesthetised pigs, brachial plexus exposed bilaterally. Up eight nerves underwent using a cannula or an needle. After 48 h, were resected. The specimens processed for visual...
<h3>Background and Objectives</h3> Perineural hematoma may occur during performance of peripheral nerve blocks. The aim this study was to test the hypothesis that an iatrogenic in immediate vicinity a cause histologic evidence injury. <h3>Methods</h3> Fifty milliliters autologous blood injected adjacent right sciatic 20 anesthetized female pigs. In order discern between blood-related volume immune effects, 50 mL albumin at same location additional 22 Either or random order. left served as...
Background & Objectives Most anesthesiologists use the injection of a test dose local anesthetic in order to evaluate final needle tip position. Thus, intraneural full can be avoided. The aim this study was analyze whether an bupivacaine could trigger histological changes. Methods Intraneural injections under direct vision were performed 40 brachial plexus nerves seven anesthetized pigs. Tibial served as positive and negative controls. Two milliliter 0.5% injected three on left plexus....
Background The objective of the study was to evaluate whether use ultrasound ( US ) together with nerve stimulation USNST provides a better needle tip position for performing peripheral regional anaesthesia than or NST alone. Methods Needle placements were applied at brachial plexus and sciatic nerves in 32 anaesthetised pigs. Following placement near target nerve, using either , volume 0.3 ml synthetic resin injected mimicking ‘test‐dose’ injection. primary outcome incidence close...
Background: The purpose of this study was to determine systematically the highest minimal stimulation current threshold for regional anaesthesia in pigs. Methods: In an established pig model anaesthesia, needle placements applying electric nerve were performed. primary outcome frequency close as assessed by resin injectates and subsequent anatomical evaluation. Following a statistical (continual reassessment method), applied output currents selected limit necessary number punctures, while...
An 81-year-old man underwent percutaneous mitral valve repair (MitraClip) due to severe symptomatic regurgitation. Coronary heart disease was excluded prior repair. Approximately 8 h after the uneventful and successful intervention, patient presented with progressive abdominal pain, in particular tenderness right upper quadrant guarding. Laboratory tests did not reveal any acute alterations; serum lactate 2.4 mmol/L. Bedside ultrasonography showed a distended ascending colon pronounced...
Background Microcalcifications within the fibrous cap of arteriosclerotic plaques lead to accrual plaque-destabilizing mechanical stress. New techniques for plaque screening with small detectors and ability differentiate between smooth hard elements formation are necessary. Method Vascular formations characterized as calcium phosphate containing structures organized hydroxylapatite resembling mineral whitlockite. In transmission reflexion studies a simple millimeter wave...
Einleitung: Die Standardbehandlung für gut-differenzierte metastasierte neuroendokrine Neoplasien des Pankreas (PNEN) ist die Chemotherapie mit 5-FU und Streptozotocin (STZ). Über prädiktive prognostische Marker in dieser Patientengruppe bislang wenig bekannt.
Wenn periphere Nervenblockaden durchgeführt werden, kann es durch ein direktes Trauma oder die intraneurale Injektion von Lokalanästhetika zur Schädigung der Nerven kommen. Weniger bekannt ist bislang, inwieweit perineurale Hämatome nach akzidenteller Punktion benachbarten Blutgefäßen ebenfalls Nervenläsionen hervorrufen können. Thorsten Steinfeldt und Kollegen haben das im Tierexperiment untersucht.
e16128 Background: Immune checkpoint inhibitors represent a new therapeutic option in metastatic RCC (mRCC) dependent on PD-1 and PD-L1 expression. We examined the occurrence amount of expressing tumor infiltrating lymphocytes (TILs)in primary (kidney) as well synchronous/metachronous metastases RCC. Aim this study was to detect possible correlations for development differences expression level between Methods: IHC performed paraffin embedded samples from patients with localised metastasized...