A5049222613- Probiotics and Fermented Foods
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Microbial Metabolites in Food Biotechnology
- Childhood Cancer Survivors' Quality of Life
- Plant Pathogens and Fungal Diseases
- Clostridium difficile and Clostridium perfringens research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Microbial Metabolism and Applications
- Microbial Community Ecology and Physiology
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
Pirogov Russian National Research Medical University
2018-2025
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2023
Three novel strains of Gram-stain-negative, obligately anaerobic, spore-forming straight or slightly curved rods with pointed ends occurring singly in pairs were isolated from the faeces healthy human children. The characterized by mesophilic fermentative metabolism and production acetate, ethanol H2 as end metabolic products. Strains ASD3451 ASD5720T motile, fermented lactose raffinose, weakly maltose. Strain ASD4241T was non-motile did not ferment carbohydrates listed above but starch....
A strain of obligately anaerobic, spore-forming, Gram-positive rods was isolated from child faeces and characterized both phenotypically genotypically. Phylogenetic analysis based on 16S rRNA gene whole genome sequencing revealed the to represent a member family Ruminococcaceae distant described species genera. The moderately saccharolytic with mannose as preferred substrate produced lactic acid, acetic acid H2 end products. major cellular long-chain fatty acids were C16 : 0 aldehyde....
Abstract Introduction B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) is the most common neoplasm in children. One of long known recurrent rearrangements BCP‐ALL t(1;19)(q23;p13.3)/ TCF3 :: PBX1 . However, other gene were also described that are associated with significant difference ALL prognosis. Methods The current study aimed to analyze spectrum children Russian Federation. A cohort 203 patients was selected based on FISH screening and studied by karyotyping, FISH, RT‐PCR high...
We report here a draft genome sequence of Megasphaera sp. ASD88, strain from the intestinal microbiota child with autism spectrum disorder, representing previously undescribed species genus Megasphaera. The assembled consists 88 scaffolds, and total size is 2.59 Mb.
In recent decades, nucleic acid sequencing technologies used for metagenomic analysis have become the main methods assessing composition of microbiota. At same time, use novel cultivation and identification microorganisms in microbiological research led to renaissance culture-based technologies, because facilitated discovery isolation both new strains well-known as well uncultivated unexplored bacterial taxa. The aim this study was evaluate potential using method assessment qualitative...
Follicular regulatory T (Tfr) cells play various roles in immune responses, contributing to both positive and negative regulation of foreign antigen-specific B cell control over autoreactive antibody responses autoimmunity, class-switching IgE allergy development. Studies conducted on mice uncovered subsets CXCR5+FoxP3+CD4+ Tfr that could differently contribute regulation. Moreover, recent studies human revealed similar complexity with follicular different origins immunosuppressive and/or...