A5034064298- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Nematode management and characterization studies
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Entomopathogenic Microorganisms in Pest Control
- T-cell and B-cell Immunology
- Nail Diseases and Treatments
- Space Science and Extraterrestrial Life
- Immune Cell Function and Interaction
- Plant-Microbe Interactions and Immunity
- Mycotoxins in Agriculture and Food
- Historical and Architectural Studies
- Climate Change and Health Impacts
- Biochemical and Structural Characterization
- Hematopoietic Stem Cell Transplantation
- Historical Astronomy and Related Studies
- Immune cells in cancer
- Medical and Biological Ozone Research
- Invertebrate Immune Response Mechanisms
- Classical Studies and Legal History
- Mycorrhizal Fungi and Plant Interactions
- Chemokine receptors and signaling
Camden and Campbelltown Hospitals
2014-2025
Western Sydney University
2016-2025
Trinity College Dublin
2009-2016
St. James's Hospital
2009-2015
University of St Andrews
2007
Rothamsted Research
2001-2003
University of Nottingham
2003
Vigor (United States)
2002
Newsweek (United States)
1997
Royal Marsden Hospital
1995
We analyzed the technical basis for a major global program to reduce disease among poor. Effective interventions exist against few diseases which most account excess mortality Achieving high coverage of effective requires well-functioning health system, as well overcoming set financial and nonfinancial constraints. The annual incremental cost would be between $40 billion $52 by 2015 in 83 low-income sub-Saharan African countries. Such is feasible avoid millions child, maternal, adult deaths...
Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role surface layer proteins (SLPs) this disease has not yet been fully explored. aim study was to investigate a for SLPs recognition C. subsequent activation immune system. Bone marrow derived dendritic cells (DCs) exposed were assessed production inflammatory cytokines, expression cell markers their ability generate T helper (Th) responses. DCs isolated from...
ABSTRACT Aspergillus PCR testing of serum provides technical simplicity but with potentially reduced sensitivity compared to whole-blood testing. With diseases for which screening exclude disease represents an optimal strategy, is paramount. The associated analytical study confirmed that DNA concentrations were greater in plasma than those serum. aim the current investigation was confirm findings by comparing performance and clinical setting. Standardized performed on samples concurrently...
Abstract Despite the strong interest in NK cell-mediated immunity toward malignant cells and viruses, there is a relative lack of data on interplay between filamentous fungi, especially Aspergillus fumigatus, which major cause invasive aspergillosis. By studying vitro interaction human A. we found only germinated morphologies to be highly immunogenic, able induce Th1-like response, capable upregulating cytokines such as IFN-γ TNF-α. Moreover, priming with rIL-2 stimulating by direct...
ABSTRACT Samples from patients at high risk for invasive aspergillosis (IA) were prospectively collected and analyzed the presence of molecular markers fungal infection. Serum specimens screened galactomannan Aspergillus DNA, whole-blood only DNA. Fungal infections categorized according to European Organization Research Treatment Cancer/Invasive Infections Cooperative Group, National Institute Allergy Infectious Diseases Mycoses Study Group (EORTC/MSG) criteria. Forty-seven cases (proven...
Molecular diagnostic assays can accelerate the diagnosis of fungal infections and subsequently improve patient outcomes. In particular, detection due to Mucorales is still challenging for laboratories physicians. The aim this study was evaluate a probe-based Mucorales-specific real-time PCR assay (Muc18S) using tissue serum samples from patients suffering invasive mucormycosis (IMM). This detect broad range clinically relevant species be used complement existing tests or screen high-risk...
Summary Invasive aspergillosis ( IA ) is a leading complication of intensive treatment for haematological malignancies. Earlier diagnosis should facilitate effective antifungal therapy and prevent progression to invasive disease, which often lethal. Polymerase chain reaction PCR assays, targeting the 28S ITS ribosomal gene regions respectively, were evaluated early detection A spergillus DNA diagnostic utility in patients receiving two busy haematopoietic stem cell transplant centres....
Dendritic cells (DC) are the most important antigen presenting and play a pivotal role in host immunity to infectious agents by acting as bridge between innate adaptive immune systems. Monocyte-derived immature DCs (iDC) were infected with viable resting conidia of Aspergillus fumigatus (Af293) for 12 hours at an MOI 5; sampled every three hours. RNA was extracted from both organisms each time point hybridised microarrays. iDC cell death increased 6 h presence A. which coincided fungal germ...
Summary The dermaseptins are a family of antimicrobial peptides from the tree‐frog Phyllomedusa sauvagii . Yeast exposed to dermaseptin S3(1‐16), truncated derivative S3 with full activity, showed diagnostic markers yeast apoptosis: appearance reactive oxygen species and fragmentation nuclear DNA. This process was independent caspase, Yca1p. Screening non‐essential gene deletion collection in identified genes that conferred resistance S3(1‐16): izh2 Δ, izh3 stm1 Δ aif1 all known be involved...
The use of serum or plasma for Aspergillus PCR testing facilitates automated and standardized technology. Recommendations are available, while regularly considered interchangeable in fungal diagnostics, differences galactomannan enzyme immunoassay (GM-EIA) performance have been reported attributed to clot formation. Therefore, it is important assess determine if previous recommendations applicable also compare analytical with that PCR. Molecular methods were compared through multicenter...
Fungi such as Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans are opportunistic pathogens in humans. They usually infect individuals whose immune system is compromised due to either a primary infection, e.g., HIV/AIDS, or part of treatment for another condition, stem cell solid organ transplant. In hosts with weakened system, these fungi can cause life-threatening infections. Unlike true pathogens, do not have specific mechanisms overcome healthy host, requiring...
Invasive aspergillosis is a significant threat to health and major cause of mortality in immunocompromised individuals. Understanding the interaction between fungus immune system important determining how immunocompetent host remains disease free. Several studies examining direct Aspergillus fumigatus purified innate cells have been conducted measure responses both pathogen. It has revealed that different modes action ranging from effective fungal killing by neutrophils less aggressive...