A5064078026- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Bacillus and Francisella bacterial research
- COVID-19 impact on air quality
- RNA Research and Splicing
- Respiratory viral infections research
- COVID-19 diagnosis using AI
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Healthcare and Environmental Waste Management
- Pneumonia and Respiratory Infections
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Pneumocystis jirovecii pneumonia detection and treatment
Aga Khan University
2022-2025
This study aimed to identify differentially expressed non-coding RNAs (ncRNAs) associated with preterm birth (PTB) and determine biological pathways being influenced in the context of PTB. We processed cell-free RNA sequencing data identified seventeen (DE) ncRNAs that could be involved onset Per validation via customized RT-qPCR, recorded variations expressions eleven were concordant in-silico analyses. The results this provide insights into role DE their impact on pregnancy-related lead...
COVID-19 waves caused by specific SARS-CoV-2 variants have occurred globally at different times. We focused on Omicron to understand the genomic diversity and phylogenetic relatedness of strains in various regions Pakistan.We studied 276,525 cases 1,031 genomes sequenced from December 2021 August 2022. Sequences were analyzed visualized using trees.The highest case numbers deaths recorded Sindh Punjab, most populous provinces Pakistan. comprised 93% all genomes, with BA.2 (32.6%) BA.5...
Wastewater-based surveillance is used to track the temporal patterns of SARS-CoV-2 virus in communities. Viral RNA particle detection wastewater samples can indicate an outbreak within a catchment area. We describe feasibility using sewage network monitor trend and use genomic sequencing viral variant abundance urban district Karachi, Pakistan. This was among first studies from Pakistan demonstrate for semi-formal system.
Next-generation sequencing technology has revolutionised pathogen surveillance over the last two decades. However, benefits are not equitably distributed, with developing countries lagging far behind in acquiring required and analytical capacity. Recent declines cost associated sequencing—equipment running consumables have created an opportunity for broader adoption. During COVID-19 pandemic, rapid diagnostics development DNA ability to diagnose sequence SARS-CoV-2 rapidly. Socioeconomic...
Abstract Background COVID-19 waves caused by specific SARS-CoV-2 variants have occurred globally at different times. We focused on Omicron to understand the genomic diversity and phylogenetic relatedness of strains in various regions Pakistan. Methods studied 276,525 cases 1,041 genomes sequenced from December 2021 August 2022. Sequences were analyzed visualized using trees. Results The highest case numbers deaths recorded Sindh Punjab, most populous provinces comprised 95% all genomes, with...
In early 2021, the 10-valent Pneumococcal conjugate vaccine (PCV10) was replaced with 13-valent (PCV13) by federal directorate of immunization (FDI), Pakistan. We assessed impact a higher valent vaccine, PCV13, on serotype distribution nasopharyngeal carriage in rural
Background: Wastewater-based surveillance has been used around the globe to track presence and temporal patterns of SARS-CoV-2 virus in communities. From time infection until 33 days later, is shed feces whereas a considerable percentage COVID-19 cases remain are asymptomatic not included clinical estimates. Therefore, viral RNA particle detection wastewater samples can indicate beginning an outbreak within catchment area well advance surveillance. We describe feasibility using sewage...