Md. Shahadat Hossain

ORCID: 0000-0003-1724-1823
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About
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Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • vaccines and immunoinformatics approaches
  • RNA modifications and cancer
  • SARS-CoV-2 detection and testing
  • COVID-19 Clinical Research Studies
  • Invertebrate Immune Response Mechanisms
  • Cancer-related molecular mechanisms research
  • Rice Cultivation and Yield Improvement
  • Aquaculture disease management and microbiota
  • Plant Stress Responses and Tolerance
  • Synthesis and biological activity
  • Genomics and Rare Diseases
  • Fibroblast Growth Factor Research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • COVID-19 diagnosis using AI
  • Peptidase Inhibition and Analysis
  • Viral Infections and Outbreaks Research
  • Circular RNAs in diseases
  • Advanced MRI Techniques and Applications
  • NF-κB Signaling Pathways
  • Agricultural Innovations and Practices
  • MicroRNA in disease regulation
  • Synthesis and Characterization of Heterocyclic Compounds
  • Psidium guajava Extracts and Applications
  • Biosensors and Analytical Detection

Noakhali Science and Technology University
2019-2024

University of Rajshahi
2021-2024

Syracuse University
2024

Kagawa University
2017-2021

Dhaka Medical College and Hospital
2013-2021

Shaheed Suhrawardy Medical College
2015-2021

Atish Dipankar University of Science and Technology
2020

Bangabandhu Sheikh Mujib Medical University
2011-2019

Institute of Water Modelling
2018-2019

University of Dhaka
2016-2017

Abstract Ras association domain-containing protein 5 (RASSF5), one of the prospective biomarkers for tumors, generally plays a crucial role as tumor suppressor. As deleterious effects can result from functional differences through SNPs, we sought to analyze most SNPs RASSF5 well predict structural changes associated with mutants that hamper normal protein–protein interactions. We adopted both sequence and structure based approaches protein. also analyzed putative post translational...

10.1038/s41598-020-71457-1 article EN cc-by Scientific Reports 2020-09-03

Lead (Pb) toxicity causes a severe impact on plant growth and productivity. A protective role of salicylic acid (SA) is well known under different abiotic stress conditions. However, very little about the SA-induced Pb resistance mechanism. In this study, we investigated effect SA mustard plants (Brassica campestris L.) Pb-stress Plants were exposed to three levels amendment soil (0.25, 0.50, 1.00 mM), with or without (0.25 mM). Plant growth, yield attributes, at harvest reduced depending...

10.5586/aa.1765 article EN cc-by Acta Agrobotanica 2019-07-01

Methicillin-Resistant Staphylococcus aureus (MRSA), a pathogenic bacterium that causes life-threatening outbreaks such as community-onset and nosocomial infections emerging 'superbug'. Time motion study of its virulent property developed resistance against most the antibiotics Vancomycin. Thereby, to curb this problem entails development new therapeutic agents. Plant-derived antimicrobial agents have recently piqued people's interest, so in research, 186 flavonoids compound selected unmask...

10.1080/07391102.2021.1944911 article EN Journal of Biomolecular Structure and Dynamics 2021-07-09

Salt stress greatly disturbs the growth, morpho-physiological, and biochemical performance of plants. However, different physiological processes acclimation mechanisms can be induced under stress, while some them modulated by appropriate chemical stimulus. The objective this study was to evaluate impact exogenous pretreatment with 10 mM l-glutamic acid (l-Glu) on parameters lentil (Lensculinaris Medik.) 110 NaCl stress. inhibited growth reduced photosynthetic pigment (chlorophylls...

10.3390/biom11040587 article EN cc-by Biomolecules 2021-04-16

Cardiovascular disease (CVD) causes a significant number of morbidity and mortality worldwide, primarily driven by dyslipidemia abnormal lipid levels. Effective management hyperlipidemia CVD typically involves using various pharmacological agents, including statins (like atorvastatin rosuvastatin), cholesterol absorption inhibitors ezetimibe), fibrates. The combined use these agents has been shown to decrease cardiovascular events effectively over long duration. This study formulated...

10.3329/bpj.v28i1.79467 article EN Bangladesh Pharmaceutical Journal 2025-01-30

Early diagnosis of breast cancer is essential for mitigating its related morbidity and mortality. Therefore, high awareness required.We aimed to evaluate the knowledge, perceived barriers among females in Bangladesh regarding cancer.A hospital-based survey was performed from April 2019 June 2019. A total 500 aged >18 years were recruited study. The participants selected by trained personnel physicians via simple random sampling.The mean participant age 37.13 ± 12.66 years. Among all...

10.1016/j.heliyon.2020.e03753 article EN cc-by Heliyon 2020-04-01

Lentil, an important source of protein for human consumption, is considered as a salt susceptible crop species. Thus the present study was carried out to evaluate most lentil physiological characters that induce tolerance. Salt stress results in osmotic immediately followed by ionic toxicity. We used iso-osmotic solutions with different kinds osmotica i.e. (NaCl and KCl), polyethylene glycol (PEG) identify specific response All these altered seedling height, chlorophyll, malondialdehyde...

10.1016/j.sajb.2017.09.007 article EN cc-by South African Journal of Botany 2017-09-29

<p><strong>Objective: </strong>This study was conducted to synthesise some 2-substituted-5-nitro benzimidazole derivatives evaluate their antioxidant activity.</p><p><strong>Methods: </strong>The titled compounds were synthesised by sodium metabisulfite mediated reaction of 4-nitro-1, 2-phenylenediamine with a number <em>para</em>-substituted benzaldehydes. The activity evaluated 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical...

10.22159/ijpps.2017v9i1.14972 article EN International Journal of Pharmacy and Pharmaceutical Sciences 2016-12-31

ABSTRACT In the course of a COVID-19 pandemic, 0.33 million people got infected in Bangladesh, we made first and successful attempt to detect SARS-CoV-2 viruses’ genetic material vicinity wastewaters an isolation centre i.e. Shaheed Bhulu Stadium, situated at Noakhali. The idea was understand loading variation, both temporal distance-wise nearby wastewater drains when number patients is not varying much. Owing fact that center, general, always contained constant 200 patients, prime objective...

10.1101/2020.09.14.20194696 preprint EN cc-by-nd medRxiv (Cold Spring Harbor Laboratory) 2020-09-18

This research aims to find out whether the 1, 2, 4-triazine and its derivatives have antifungal effects can protect humans from infection with Candida albicans. Molecular docking molecular dynamic simulation are widely used in modern drug design target a particular protein ligand. We interested using dynamics modeling investigate interaction between of enzyme Lanosterol 14-demethylase (CYP51) The inhibition albicans CYP51 is main goal our research. been docked enzyme, which involved...

10.3389/fmedt.2022.845322 article EN cc-by Frontiers in Medical Technology 2022-03-28

Abstract Background COVID-19 has become a global pandemic with high growth rate of confirmed cases. In Bangladesh, both mortality and affected rates are increasing at an alarming rate. Therefore, more comprehensive studies the epidemiological clinical characteristics required to control this pandemic. Purpose The present study aimed compare analyze sex-specific epidemiological, characteristics, comorbidities, other information patients from southeast region in Bangladesh for first time....

10.1101/2021.07.05.21259933 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2021-07-07

The presence of white spot syndrome virus (WSSV) in wildPenaeus monodon, other wild shrimps, and non-cultured crustaceans from shrimp ponds/ghers Bangladesh was studied by polymerase chain reaction (PCR).Wild shrimps viz.P. mondon, P.semisulcatus, P.indicus, Metapenaeus monoceros, M. brevicornisandPalaemon styliferuswere positive for WSSV.The brevicornis, freshwater prawnMacrobrachium rosenbergii, crabsScylla serrataandPseudograpsus intermediusfrom were WSSV positive.This is the first study...

10.3147/jsfp.36.93 article EN Fish Pathology 2001-01-01

A new strain of the beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is solely responsible for ongoing disease 2019 (COVID-19) pandemic. Although several studies suggest that spike protein this virus interacts with cell surface receptor, angiotensin-converting enzyme (ACE2), and subsequently cleaved by TMPRSS2 FURIN to enter into host cell, conclusive insight about interaction pattern variants these proteins still lacking. Thus, in study, we analyzed functional...

10.1177/11779322211054684 article EN cc-by-nc Bioinformatics and Biology Insights 2021-01-01

Genomic data analysis is a fundamental system for monitoring pathogen evolution and the outbreak of infectious diseases. Based on bioinformatics deep learning, this study was designed to identify genomic variability SARS-CoV-2 worldwide predict impending mutation rate. Analysis 259044 isolates identified 3334545 mutations with an average 14.01 per isolate. Globally, single nucleotide polymorphism (SNP) most prevalent mutational event. The prevalence C > T (52.67%) noticed as major alteration...

10.1016/j.imu.2021.100798 article EN cc-by-nc-nd Informatics in Medicine Unlocked 2021-01-01

Along with intrinsic evolution, adaptation to selective pressure in new environments might have resulted the circulatory SARS-CoV-2 strains response geoenvironmental conditions of a country and demographic profile its population. With this target, current study traced evolutionary route mutational frequency 198 Bangladesh-originated genomic sequences available GISAID platform over period 13 weeks as 14 July 2020. The analyses were performed using MEGA X, Swiss Model Repository, Virus...

10.1007/s11262-021-01860-x article EN other-oa Virus Genes 2021-07-12
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