A5009873602- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- COVID-19 diagnosis using AI
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Plant-Microbe Interactions and Immunity
- Obesity, Physical Activity, Diet
- Artificial Intelligence in Healthcare
- Regulation of Appetite and Obesity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biochemical and Structural Characterization
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Genetic Associations and Epidemiology
- Biochemical Analysis and Sensing Techniques
- interferon and immune responses
- Phosphodiesterase function and regulation
- Diabetes Treatment and Management
- SARS-CoV-2 detection and testing
- Machine Learning in Healthcare
- Fungal Biology and Applications
- COVID-19 Clinical Research Studies
- Enzyme Production and Characterization
Noakhali Science and Technology University
2020-2024
Obesity is a chronic condition which identified by the buildup of excess body fat caused combination various factors, including genetic predisposition and lifestyle choices. rs1137101 (A > G) polymorphism in CHR1 domain LEPR protein linked to different diseases obesity. Nevertheless, connection between this likelihood developing obesity has not been determined definitively. Therefore, meta-analysis was conducted assess relationship risk The included all studies meeting pre-defined criteria,...
In humans, the dimeric receptor complex IFNAR2-IFNAR1 accelerates cellular response triggered by type I interferon (IFN) family proteins in to viral infection including Coronavirus infection. Studies have revealed association of IFNAR2 gene with severe illness and indicated genomic variants, i.e. single nucleotide polymorphisms (SNPs). However, comprehensive analysis SNPs has not been performed both coding non-coding region find causes loss function COVID-19 patients. this study, we...
A new strain of the beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is solely responsible for ongoing disease 2019 (COVID-19) pandemic. Although several studies suggest that spike protein this virus interacts with cell surface receptor, angiotensin-converting enzyme (ACE2), and subsequently cleaved by TMPRSS2 FURIN to enter into host cell, conclusive insight about interaction pattern variants these proteins still lacking. Thus, in study, we analyzed functional...
Genomic data analysis is a fundamental system for monitoring pathogen evolution and the outbreak of infectious diseases. Based on bioinformatics deep learning, this study was designed to identify genomic variability SARS-CoV-2 worldwide predict impending mutation rate. Analysis 259044 isolates identified 3334545 mutations with an average 14.01 per isolate. Globally, single nucleotide polymorphism (SNP) most prevalent mutational event. The prevalence C > T (52.67%) noticed as major alteration...
Type 2 Diabetes Mellitus (T2DM) occurs due to a complex relationship of genetic, environmental, and physiological factors, encompassing insufficient pancreatic insulin synthesis, peripheral resistance, diverse molecular pathways. The transmembrane glycoprotein ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) plays role in regulation, with the K121Q (rs1044498) variant on ENPP1 gene being subject extensive study its potential association T2DM. To comprehensively evaluate this...
Mucormycosis is a life-threatening fungal infection, particularly in immunocompromised patients. has been reported to show resistance available antifungal drugs and was recently found COVID-19 as co-morbidity that demands new classes of drugs. In an attempt find novel inhibitors against the high-affinity iron permease (FTR1), target having fundamental importance on pathogenesis mucormycosis, 11,000 natural compounds were investigated this study. Virtual screening molecular docking identified...
Aberrant expression of long non-coding RNAs (lncRNAs), caused by alterations in DNA methylation, is a driving factor several cancers. Interplay between lncRNAs' aberrant methylation and prostate cancer (PC) progression still remains largely elusive. Therefore, this study characterized the genome-wide epigenetic landscape profiles lncRNAs their clinical impact integrating multi-omics data implementing bioinformatics approaches. We identified 62 differentially methylated CpG-sites (DMCs) 199...
MicroRNAs play a crucial role in tumorigenesis, tumor progression, and metastasis, thus they contribute development of different malignancies including cervical cancer (CC) colorectal (CRC). Through integrated strategies computational biology, this study aims to identify prognostic biomarkers responsible for CRC CC prognosis, potential therapeutic agents halt the progression these cancers. Expression analysis miRNA datasets identified 17 differentially expressed miRNAs (DEMs). SYNPO2, NEGR1,...
miRNAs are endogenous, non-coding and evolutionarily conserved RNA molecules. They have been found to be involved in the progression proliferation of various cancers due their contribution post-transcriptional regulation. Stomach Adenocarcinoma (STAD) Liver Hepatocellular Carcinoma (LIHC) two most common upper intestinal tract. Our study aimed evaluate circulating from both STAD LIHC samples identify commonly dysregulated as biomarkers detect at same time. Common differentially expressed...
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the novel coronavirus responsible for ongoing pandemic of disease (COVID-19). No sustainable treatment option available so far to tackle such a public health threat. Therefore, designing suitable vaccine overcome this hurdle asks immediate attention. In study, we targeted design multi-epitope based using immunoinformatics tools. We considered structural proteins S, E and, M SARS-CoV-2, since they facilitate infection...
Abstract Genomic data analysis is a fundamental system for monitoring pathogen evolution and the outbreak of infectious diseases. Based on bioinformatics deep learning, this study was designed to identify genomic variability SARS-CoV-2 worldwide predict impending mutation rate. Analysis 259044 isolates 3334545 mutations (14.01 per isolate), suggesting high Strains from India showed highest no. (48) followed by Scotland, USA, Netherlands, Norway, France having up 36 mutations. Besides most...
Introduction: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has jeopardized our health system and leaving everyone in disarray. Despite the diligent cumulative effort academia, there is hardly any light end tunnel so far developing efficient sustainable treatment options to tackle this public threat. Therefore, designing a suitable vaccine overcome hurdle calls for immediate attention. current study...