A5090556446- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Cardiac and Coronary Surgery Techniques
- Pulmonary Hypertension Research and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Cardiac Valve Diseases and Treatments
- Tracheal and airway disorders
- Anesthesia and Neurotoxicity Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Mechanical Circulatory Support Devices
- Acute Ischemic Stroke Management
- Blood transfusion and management
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Cardiac Ischemia and Reperfusion
- Aortic aneurysm repair treatments
- Muscle activation and electromyography studies
- Hemostasis and retained surgical items
- Cardiomyopathy and Myosin Studies
- Transplantation: Methods and Outcomes
- Venous Thromboembolism Diagnosis and Management
Klinikum Bremen-Mitte
2016-2024
Charité - Universitätsmedizin Berlin
2018
Justus-Liebig-Universität Gießen
2018
Winterthur Museum Garden and Library
2016
L-3 Communications (United States)
2015
Heinrich Heine University Düsseldorf
2009-2012
Medizinische Hochschule Hannover
2002-2011
Düsseldorf University Hospital
2009-2011
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
2007-2009
European Society of Anaesthesiology
2009
Bleeding diathesis after aortic valve operation and ascending aorta replacement (AV-AA) is managed with fresh-frozen plasma (FFP) platelet concentrates. The aim was to compare haemostatic effects of conventional transfusion management FIBTEM (thromboelastometry test)-guided fibrinogen concentrate administration.A blood products algorithm developed using retrospective data from 42 elective patients (Group A). Two units were transfused cardiopulmonary bypass, followed by 4 u FFP if bleeding...
Auricular acupuncture can be an effective treatment for acute anxiety, but there is a lack of direct comparisons to proven standard drug treatments. In this study we compared the efficacy auricular with intranasal midazolam, placebo acupuncture, and no reducing dental anxiety. Patients having extractions (n = 67) were randomized (i) (ii) (iii) midazolam group. Anxiety was assessed before interventions, at 30 min, after extraction. Physiological variables continuously. With group as control,...
Background: Platelet dysfunction contributes to the pathophysiology of bleeding complications during and after cardiac surgery. In most surgical institutions, no peri‐operative point‐of‐care monitoring platelet function is used. We evaluated usefulness Multiplate ® analyser based on impedance aggregometry for identifying groups patients at a high risk transfusion concentrates (PC). Methods: parameters were determined in 60 before routine Impedance measurements performed using ADP (ADPtest),...
Our aim was to compare a continuous infusion of remifentanil with intermittent boluses fentanyl as regards the perioperative hormonal stress response and inflammatory activation in coronary artery bypass graft patients under sevoflurane-based anaesthesia.In all, 42 undergoing grafting cardiopulmonary were prospectively randomized group (n = 21, total dose 2.6 +/- 0.3 mg), or rate 0.25 microg kg(-1) min(-1)). Haemodynamics, plasma levels epinephrine, norepinephrine, antidiuretic hormone,...
Current devices for measuring muscle contraction in vivo have limited accuracy establishing and re-establishing the optimum length. They are variable reproducibility to determine at this length, often do not maintain precise conditions during examination. Consequently, clinical testing only semi-quantitative methods been used.We present a newly developed myograph, an accurate device contraction, consisting of three elements. Firstly, element adjusting axle physiological axis contraction;...
Monitoring of cardiovascular function is essential during major pediatric and cardiac surgery. Invasive monitoring output (CO) oxygen delivery expensive sometimes associated with adverse events. Therefore, we investigated the accuracy a new noninvasive CO device using electrical velocimetry (EV) in comparison more invasive transpulmonary thermodilution (TPTD) method.In five fasted, anesthetized mechanically ventilated piglets, was measured simultaneously EV TPTD under normal conditions,...
Background Remote ischemic preconditioning ( RIPC ) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 surgery patients receiving either or sham‐ . Methods and Results In this follow‐up paper, present 1‐year composite primary end point its individual components (all‐cause mortality, myocardial infarction,...
The minimized extracorporeal circulation system (MECC) is being used to reduce priming volume and blood/polymer contact during cardiac procedures. In this study, we evaluated the efficacy potential advantages of in coronary artery bypass graft (CABG) patients. We included two groups patients destined for CABG a prospective, randomized study: Group A was operated on usual pump (n = 30) while B using MECC 50). Pre-operative demographics, intra-operative times values as well series...
Platelet dysfunction due to antiplatelet therapy contributes perioperative bleeding. Several trials investigating the influence of aspirin intake within 5 days before surgery reported that transfusion requirements were either increased or not significantly affected by intake. Our objective was compare assessment patient self-reporting and measurement platelet function with regard requirements.In a prospective trial, standardized questionnaire used in 100 patients for immediately coronary...
Objective: Clinically, selective antegrade cerebral perfusion (SACP) seems to be associated with a better neurological outcome compared hypothermic circulatory arrest (HCA) alone, but the pathophysiological mechanisms are not well understood. Therefore, this study was undertaken assess effects of HCA and without SACP on integrity using multimodal neurophysiological monitoring. Methods: 12 pigs were randomly assigned 100 min at 20 °C brain temperature (n=6) SACP. Haemodynamics, metabolics...
Objective: To investigate whether deep (≪20 °C) hypothermia is necessary in patients undergoing pulmonary endarterectomy for chronic thromboembolic hypertension. Methods: Between January 2004 and February 2005, 30 (New York Heart Association (NYHA) class III or IV) were randomly assigned to increasing (1 levels of moderate (28–32°C) hypothermic cardiopulmonary bypass (CPB), each study group including six patients. Primary endpoint was adverse neurological outcome. Overall preoperative total...
Pulmonary hypertension (PH) is an independent risk factor for increased mortality in patients undergoing heart surgery. Existing chronic PH may be exacerbated by acute post-bypass PH, and this can lead to right ventricular failure. The prevention treatment of failure cardiac surgery based on three principles: optimize preload, improve contractility, minimize afterload. last these involve specific measures such as the inhalation nitric oxide (NO) or stable prostacyclin analogue iloprost....
The cardiopulmonary bypass (CPB) used in heart surgery has a deleterious effect on hemostasis. aim of our study was to assess by means standard laboratory and point-of-care methods changes induced CPB coagulation parameters, particularly platelet function, determine whether these differ depending the type heart-lung machine (HLM) used: minimal extracorporeal circulation system (MECC) HLM. enrolled 88 patients scheduled for coronary artery performed pump. Forty-four interventions were with...