A5091218311- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- interferon and immune responses
- Genital Health and Disease
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- RNA Research and Splicing
- Dermatology and Skin Diseases
- Genomics and Chromatin Dynamics
- Bladder and Urothelial Cancer Treatments
- Family Support in Illness
- Social and Educational Sciences
- Diagnosis and treatment of tuberculosis
- AI in cancer detection
- Cytomegalovirus and herpesvirus research
- Breast Lesions and Carcinomas
- Childhood Cancer Survivors' Quality of Life
- Breast Cancer Treatment Studies
Ryhov Hospital Jönköping
2021
Sahlgrenska University Hospital
2010-2018
University of Gothenburg
2014
Abstract External quality assessment (EQA) schemes for pathology are essential, yet large/international programmes do not assess morphology-based biomarkers or address local/regional needs. This study outlines bottom-up initiated, flexible Swedish Digital Pathology EQA rounds breast pathology, and presents results from the 2021 2023 rounds. Six carcinoma cases were selected each round by Breast Expert Group (KVAST Breast). Whole tissue slides stained with HE, IHC, ISH anonymized, digitized,...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? Intravesical BCG treatment has been used worldwide for many decades but there are only a few published reports persisting infection urinary bladder. This is first report large tuberculosis‐like ulcers bladder after intravesical treatment. The finding results in recommendation to take urine cultures mycobacteriae patients with unclear inflammatory lesions instillation BCG. OBJECTIVE To...
Myxoid/round-cell liposarcoma (MLS/RCLS) is characterized by either the fusion gene FUS-DDIT3 or less commonly occurring EWSR1-DDIT3 and most cases carry few no additional cytogenetic changes. There are conflicting reports concerning status role of TP53 in MLS/RCLS. Here we analysed four MLS/RCLS derived cell lines for mutations, expression function. Three SV40 transformed expressed normal proteins. Irradiation caused posttranslational modifications induced P21 two these lines. Transfection...
Liposarcomas are mesenchymal tumors containing variable numbers of lipoblasts or adipocytes. The most common entities, well differentiated/dedifferentiated liposarcoma (WDLS/DDLS) and myxoid/round cell (MLS/RCLS), both characterized by genetic rearrangements that affect the expression transcription factor DDIT3. DDIT3 induces morphology when ectopically expressed in a human fibrosarcoma. role lipomatous is, however, unclear. We have analyzed 37 cases (WDLS/DDLS n = 10, MLS/RCLS 16,...
Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common type and characterized by fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. Previous analysis of cycle regulatory proteins revealed a prominent expression G1-cyclins, cyclin dependent kinases, their inhibitors but very few cells progressing through G1/S boundary. Here, we extend investigation to involved in senescence an immunohistochemistry based study 17 MLS/RCLS cases. Large subpopulations tumor expressed RBL2 pocket protein...
This study aimed to assess mast cell density in the lamina propria for possible correlation with duration of symptom amelioration after transurethral resection bladder (TURB).Twelve patients (eight women and four men) referred tertiary referral facility, treated between June 2003 2009, were included study. All had undergone three consecutive complete TURB procedures, where first one was also diagnostic. fulfilled NIH-NIDDK criteria ESSIC pain syndrome/interstitial cystitis type 3C criteria;...
The aim of this study was to assess whether sclerosis in histology following bulbar urethroplasty is a predictive factor for failure surgery. Resected stricture specimens from 45 patients undergoing open with excision and anastomosis were collected prospectively during 2011-2014. Histopathological characteristics, including fibrosis (grade I-III), inflammation sclerosis, evaluated using different routine staining. These compared normal urethral resection sex-correction uropathologist who...
The underlying cause of a urethral stricture can sometimes be obscure. It is possible that an injury to the urethra induces immunological cascade generates scar tissue and fibrosis, eventually resulting in stricture. If such reactions could better elucidated, therapies possibly emerge. To evaluate if ectopic germinal centres exist disease. Resected specimens from 45 patients undergoing open bulbar urethroplasty with excision anastomosis were assessed. Histopathological characteristics, as...
Bladder pain syndrome/interstitial cystitis is a condition with the leading clinical symptoms related to bladder, such as and voiding frequency. The present understanding that there are variety of presentations representing different pathological entities, even though sharing similar symptomatology same chronic course. Only subset patients has bleeding lesions seen in cystoscope bladder distension, previously described ulcers, microscopic changes interstitial inflammation, fibrosis...