Abstract Parkinson's disease (PD), a progressive neurodegenerative movement disorder, is known to be caused by diverse pathological conditions resulting from dysfunction of the ubiquitin‐proteasome system (UPS), mitochondria, and oxidative stress leading preferential nigral dopamine (DA) neuron degeneration in substantia nigra. In present study, we evaluated novel D3 receptor‐preferring agonist D‐264 mouse model PD evaluate its neuroprotective properties against both nigrostriatal...

Both unilateral biportal endoscopic discectomy (UBED) and percutaneous interlaminar (PEID) could achieve favorable outcomes for lumbar disc herniation (LDH). There are limited studies comparing the two different methods of discectomy. The objective was to comprehensively compare clinical outcome muscle invasiveness UBED PEID treatment LDH at L5/S1 level with least 1-year follow-up.The retrospective cohort study enrolled 106 patients from January 2018 December 2020. were 51 who underwent (22...

As a complication-prone operation, deep brain stimulation (DBS) has become the first-line surgical approach for patients with advanced Parkinson's disease (PD). This study aimed to evaluate incidence and risk factors of DBS-associated complications.We have reviewed consecutive series PD undergoing DBS procedures describe type, severity, management, outcome postoperative complications from January 2011 December 2018. Both univariate multivariate analyses were performed identify statistically...

Endothelial dysfunction and disruption of the blood-brain barrier have been found to be associated with Parkinson's disease (PD). However, mechanisms underlying these effects yet elucidated. It has also that activated protein C (APC) displays neuroprotective properties. Presently, APC on PD remain unknown. Using a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) neurotoxin rodent model PD, we administration MPTP can reduce expression endothelial receptor (EPCR), an N-glycosylated type...

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective for treatment Parkinson's disease (PD). Moreover, remote programming widely used in Mainland China. This necessitates evaluating ability to achieve ideal postoperative effect. Therefore, we aimed retrospectively evaluate effects different modes on effectiveness STN-DBS 12 months postoperatively patients with PD.Clinical data were collected retrospectively, before and after surgery, 83 PD. Based voluntarily selected by...

To identify age-related radiographic risk factors for degenerative lumbar spinal stenosis (DLSS) and analyze correlations among them.A total of 180 cases were enrolled in this study, magnetic resonance was performed. Among them, 93 suffered DLSS dynamic X-ray examined. And following parameters measured evaluated: intervertebral disk height (IDH), the ratio IDH(IDHL4-5/L3-4), initial IDH L4-5(iIDHL4-5) group, degeneration (DD), cartilaginous endplate failure (CEF), Modic changes, thickness...

To evaluate the radiologic parameters of degenerative lumbar spondylolisthesis (DLS) and determine radiographic risk factors for DLS by making comparisons with healthy control subjects.Seventy-five patients L4/5 (Meyerding grade I) 53 subjects were analyzed. The L1-S1 disc height index (DHI), facet joint angle (FJA), relative cross-sectional area (RCSA) paravertebral muscles measured in both groups. initial DHI (iDHI) before onset estimated based on L3/4 group group. sagittal also included...

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease (PD). The G2385R variant LRRK2 a risk factor PD in Han Chinese individuals. We retrospectively compared clinical outcomes STN-DBS surgery between carriers and non-carriers. Fifty-seven patients with bilateral were enrolled, including 8 G2385R+ (G2385R+ group) 49 non-carriers (G2385R- group). Clinical data included Unified Disease Rating Scale (UPDRS) parts I to IV,...

Background: Non-motor symptoms in PD usually arise at very early stage and vary during the whole disease progression. Deep brain stimulation (DBS) is considered as a highly efficient treatment option for PD's motor function. However, effect of DBS on NMS, especially hyposmia, has not been fully understood deep connection between different NMS such hyposmia constipation still unknown. Objective: The objective this study was to evaluate therapeutic patients with or without find potential...

Sciatica-related spinal imbalance could be observed in lumbar disc herniation (LDH) patients. However, their characteristics and recovery process remained unclear. The purpose was to analyze the radiological of related sciatica following endoscopic discectomy.The records LDH patients with receiving discectomy were retrospectively reviewed. divided Group A (sagittal imbalance), B (coronal imbalance) C coronal imbalance). whole-spine x-ray performed at pre-operation, immediately...

Subarachnoid hemorrhage (SAH) is a severe brain condition associated with significantly high incidence and mortality. As consequence of SAH, early injury (EBI) may contribute to poor SAH patient outcomes. Apoptosis signaling pathway contributing post-SAH the diagnosis disease. Fluoxetine well-studied serotonin selective reuptake inhibitor (SSRI). However, its role in apoptosis has not been clearly understood. The present investigation assessed effects potential Notch1/ASK1/p38 MAPK EBI after...

How to minimize postoperative pain following spinal surgery has been a great challenge for both surgeons and patients. We hypothesized that intraoperative multi-drug wound infiltration could relieve single-level transforaminal lumbar interbody fusion (TLIF) surgery.To evaluate the effect of TLIF surgery.A randomized, double-blinded controlled trial (RCT).Department Orthopaedic Surgery, Qilu Hospital Shandong University.The RCT enrolled 50 patients with 25 cases in 2 groups. The study group...

How to minimize postoperative pain following spinal surgery has been a great challenge. We hypothesized that topical nonsteroidal anti-inflammatory drugs (NSAIDs) around the incision could relieve transforaminal lumbar interbody fusion (TLIF) surgery.This study tested effect of NSAIDs for management after TLIF surgery.A double-blind randomized controlled trial.Qilu Hospital Shandong University.Eighty patients who underwent single-level were into 2 groups. The treatment group received...

Abstract Aim To explore the prevalence of depressive symptoms among patients with chronic heart failure (CHF) and analyse relationship between free fatty acids (FFAs), body mass index (BMI) CHF. Design A cross‐sectional study. Methods Questionnaires were distributed to 200 CHF in department Cardiology at a tertiary first‐class hospital Shandong province. total 195 hospitalized completed survey. Data collected from February 2017–November 2017 analysed by using Pearson's correlation multiple...

Objective To investigate the optimum ratio of medicine dosage for dexmedetomidine mixed with oxycodone used patient-controlled intravenous analgesia (PCIA) after gastrointestinal surgery. Methods Eighty patients both sexes, aged 35–64 yr, weighing 55–75 kg, American Society Anesthesiologists physical status Ⅰor Ⅱ, undergoing elective surgery, were randomly divided into 4 groups (n=20 each) using a random number table: group (group O), and different ratios when was added to sufentanil...

Objective To investigate the efficacy and safety of Irbesartan Hydrochlorothiazide combined with Metoprolol as initial therapy in treatment heart failure elderly. Methods A total 128 elderly patients admitted into our hospital from September 2017 to August 2018 were randomly divided Group A(n=64)and B(n=64). A was treated oral tablets.Group B sustained-release tablets addition what given A. Therapeutic effects compared between groups. Results Compared A, effectiveness rate group...

Abstract Objectives: To identify age-related radiographic risk factors for DLSS and analyze correlations among them. Methods: 180 cases were enrolled in this study, lumbar magnetic resonance was performed. Among them, 93 suffered dynamic X-ray examined. And following parameters measured: intervertebral disc height(IDH), the ratio of IDH(IDHL4-5/L3-4), initial IDH L4-5(iIDHL4-5) group, degeneration (DD), cartilaginous endplate failure(CEF), Modic changes, thickness ligamentum flavum(LF),...