A5100748605- Hearing, Cochlea, Tinnitus, Genetics
- Electrocatalysts for Energy Conversion
- Nerve injury and regeneration
- Fuel Cells and Related Materials
- Hearing Loss and Rehabilitation
- Cancer-related molecular mechanisms research
- Advanced battery technologies research
- Signaling Pathways in Disease
- Neurogenesis and neuroplasticity mechanisms
- Ion Channels and Receptors
- Vestibular and auditory disorders
- Peroxisome Proliferator-Activated Receptors
- Asthma and respiratory diseases
- Plant Molecular Biology Research
- Catalytic Processes in Materials Science
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Memory and Neural Computing
- Connexins and lens biology
- Ion channel regulation and function
- RNA regulation and disease
- Ear Surgery and Otitis Media
- Facial Nerve Paralysis Treatment and Research
- Axon Guidance and Neuronal Signaling
- Neurobiology and Insect Physiology Research
- Tea Polyphenols and Effects
Affiliated Hospital of Nantong University
2014-2025
Nantong University
2014-2025
Second Affiliated Hospital of Nantong University
2024
Yuhuangding Hospital
2020-2024
Qingdao University
2024
Panzhihua University
2023
Binzhou Medical University
2009-2023
Binzhou University
2011-2023
National University of Defense Technology
2022
Shanxi Medical University
2018-2021
Abstract Engineering the electronic configuration and intermediates adsorption behaviors of high‐performance non‐noble‐metal‐based catalysts for sluggish oxygen reduction reaction (ORR) kinetics at cathode is highly imperative development anion exchange membrane fuel cells (AEMFCs), yet remains an enormous challenge. Herein, a rare‐earth metal oxide engineering tactic through formation Fe 3 O 4 /La 2 heterostructures in N,O‐doped carbon nanospheres (Fe @N,O‐CNSs) efficient electrocatalysis...
Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9 tools. However, it is difficult to precisely assess performance in vivo because tissues contain many non-targeted cells, which one major barriers clinical translation. Here, Atoh1-GFP;Kcnq4+/G229D mice, recapitulating a novel mutation we identified hereditary hearing loss pedigree, high-efficiency hair (34.10% on average) was detected by sorting out labeled compared only 1.45% efficiency whole cochlear...
Expediting the torpid kinetics of oxygen reduction reaction (ORR) at cathode with minimal amounts Pt under acidic conditions plays a significant role in development proton exchange membrane fuel cells (PEMFCs). Herein, novel Pt–N–C system consisting single atoms and nanoparticles anchored onto defective carbon nanofibers is proposed as highly active ORR catalyst (denoted Pt–N–C). Detailed characterizations together theoretical simulations illustrate that strong coupling effect between...
Mutations in TBC1D24 have been linked to a variety of epileptic syndromes and recently syndromic hearing impairment DOORS syndrome nonsyndromic DFNB86. All mutations reported so far were inherited the recessive mode. In dominant family segregated with late-onset, progressive, impairment, linkage analysis revealed 2.07 Mb candidate region on chromosome 16p13.3 that contains TBC1D24. Whole-exome sequencing identified heterozygous p.Ser178Leu variant as only mutation segregating loss within...
Expediting the torpid kinetics of acidic oxygen reduction reaction (ORR) is a crucial yet formidable challenge toward advancing proton exchange membrane fuel cells (PEMFCs) for commercialization. The cutting-edge Pd-based nanomaterials ORR are hindered by their low intrinsic activities and significant CO poisoning, stemming from simultaneously optimizing surface adsorption various adsorbates. Herein, we introduce an ultrathin PdRhCu ternary metallene (PdRhCu metallene) boosting in PEMFC....
Exploring high-performance non-precious metal-based electrocatalysts for the sluggish oxygen evolution reaction (OER) process is fundamentally significant development of multifarious renewable energy conversion and storage systems. Oxygen vacancy (Vo) engineering an effective leverage to boost intrinsic activity OER, but underlying catalytic mechanism remains anfractuous. Herein, we realize construction vacancy-enriched porous NiO/ln2O3 nanofibers (designated as Vo–NiO/ln2O3@NFs hereafter)...
Nonsyndromic hearing loss has been shown to have high genetic heterogeneity. In this report, we aimed disclose the causes of subjects from ten Chinese deaf families who did not pathogenic common genes/mutation. Next-generation sequencing (NGS) 142 known deafness genes was performed in probands followed by cosegregation analysis all family members. We identified novel variants six including p.D1806E/p.R1588W, p.R964W/p.R1588W, and p.G17C/p.G1449D CDH23; p.T584M/p.D1939N LOXHD1; p.P1225L...
Apoptosis of cochlear hair cells is a key step towards age-related hearing loss. Although numerous genes have been implicated in the genetic causes late-onset, progressive loss, few show direct links to proapoptotic process. By genome-wide linkage analysis and whole exome sequencing, we identified heterozygous p.L183V variant THOC1 as probable cause progressive, non-syndromic loss large family with autosomal dominant inheritance. Thoc1, member conserved multisubunit THO/TREX...
There is a pressing need to further our understanding of the mechanisms underlying depression symptoms in patients with post-stroke (PSD) order inform targeted therapeutic approaches. While previous research has demonstrated reorganization functional brain network PSD, it remains uncertain whether, or not also occurs structural network. We therefore aim investigate PSD as compared non-depression (PSND) patients. In addition, considers relationship between metrics and measurements. Thirty-one...
Many studies have examined the beneficial effects of tea polyphenols (TP) and proanthocyanidins (PC) on memory impairment in different animal models. However, combined them synaptic, dysfunction molecular mechanisms been poorly studied, especially menopause-related decline rats.In this rat study, TP PC were used to investigate their protective caused by inflammation. We characterized learning abilities, synaptic plasticity, AMPAR, phosphorylation p38 protein, TNF-ɑ, structural...
Several single nucleotide polymorphisms (SNPs) of the Glutamate metabotrophic receptor 7 gene (GRM7) have recently been identified by genome-wide association study (GWAS) as potentially playing a role in susceptibility to age-related hearing impairment (ARHI), however this has not validated Han Chinese population. The aim was determine if these SNPs are also associated with ARHI an elderly male In case-control candidate genes study, total 982 men and 324 normal-hearing controls subjects were...
Abstract Background Nonsyndromic hearing loss is clinically and genetically heterogeneous. In this study, we characterized the clinical features of 12 Chinese Han deaf families in which mutations common deafness genes GJB2 , SLC26A4, MT‐RNR1 were excluded. Methods Targeted next‐generation sequencing 147 known was performed probands 10 families, while whole‐exome applied those rest two. Results Pathogenic a total 11 rare genes, OTOF CDH23 PCDH15 PDZD7 ADGRV1 KARS OTOG GRXCR2 MYO6 GRHL2 POU3F4...
Abstract Knockout of GAS2 (growth arrest-specific protein 2), causes disorganization and destabilization microtubule bundles in supporting cells the cochlear duct, leading to hearing loss vivo. However, molecular mechanism through which variant results remains unknown. By Whole-exome sequencing, we identified a novel heterozygous splicing (c.616–2 A > G) as only candidate mutation segregating with late-onset progressive nonsyndromic (NSHL) large dominant family. This an intron retention...
The reasonable design and modulation of the electronic properties Pd metallene are acknowledged as a promising avenue for enhancing oxygen reduction reaction (ORR) in anion exchange membrane fuel cells (AEMFCs), yet they remain formidable challenge. Herein, thin-sheet structure Zr-doped (PdZr metallene) with abundant defects is proposed using facile wet-chemical approach efficient highly durable ORR electrocatalysis. Multiple microstructural analyses uncover that orchestrated oxophilic...
The quest for economical and highly efficient nanomaterials the alkaline hydrogen oxidation reaction (HOR) is imperative in advancing technology of anion exchange membrane fuel cells (AEMFCs). Efforts using Pt-based electrocatalysts HOR are greatly plagued by their finitely intrinsic activities significant CO poisoning, stemming from difficulty simultaneously optimizing surface adsorption toward different hydrogen-related adsorbates. Herein, Ru clusters coupled with Eu2O3 immobilized within...
Heart failure (HF) is a serious threat to human health. Long noncoding RNAs (lncRNAs) are critical regulators of HF. The aim the study was investigate molecular mechanism MALAT1 in HF rats. expression detected serum normal volunteers and patients, rats isoproterenol (ISO)‑induced H9C2 cells, its diagnostic value evaluated patients. Indexes related cardiac functions hemodynamics, myocardial injury, lipid metabolism, oxidation, inflammation were detected. Moreover, downstream predicted...
Gliomas are one of the most common primary brain tumors in adults. They display aggressive invasiveness, highly vascular, and have a poor prognosis. Plexin-B1 is involved numerous cellular processes, especially migration angiogenesis. However, role regulatory mechanisms gliomas not understood were thus investigated this study. By using multiple diverse experimental techniques, we cell apoptosis, mitochondrial membrane potential, invasion, angiogenesis, PI3K Akt phosphorylation, also levels...
Abstract The pathogenic variants in KCNQ4 cause DFNA2 nonsyndromic hearing loss. However, the understanding of genotype–phenotype correlations between and is limited. Here, we identified a novel mutation p.G228D from Chinese family, including heterozygotes characterized by high‐frequency loss that progressive across all frequencies homozygotes with more severe We constructed murine model humanized homologous Kcnq4 mutation. had mid‐frequency at 4 weeks, moved toward 12 while...