A5092846619- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Leptospirosis research and findings
- Malaria Research and Control
- Global Public Health Policies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Protein Structure and Dynamics
- Bioactive Compounds and Antitumor Agents
- Biochemical Acid Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
Institute of Biomedical Science
2025
Universidade de São Paulo
2023-2025
Herein, we present a novel esterase enzyme, Ade1, isolated from metagenomic library of Amazonian dark earths soils, demonstrating its broad substrate promiscuity by hydrolyzing ester bonds linked to aliphatic groups. The three-dimensional structure the enzyme was solved in presence and absence (tributyrin), revealing classification within α/β-hydrolase superfamily. Despite being monomeric enzymatic assays reveal cooperative behavior with sigmoidal profile (initial velocities vs...
The Leptospiraceae family, which includes the genera Leptospira, Leptonema, and Turneriella, is an ecologically diverse group that saprophytic strains from soil water as well important pathogenic strains. Adaptation to these multiple environments relies strongly on signal transduction adjust their morphology, motility, metabolism changing environmental conditions. Members of genus Leptospira distinguish themselves among spirochetes for having elevated number genes. In this study, we describe...
Dengue fever, caused by the dengue virus (DENV), presents a significant global health challenge, especially in tropical and subtropical regions. In 2024, cases Brazil are four times higher than 2023, with increase deaths. This serves as warning for potential new outbreaks non-tropical areas. Herein, we explored various aspects of DENV transmission, clinical manifestations, epidemiological trends, management strategies. transmission involves Aedes mosquitoes vectors humans host, influenced...
Dengue fever, caused by the dengue virus (DENV), presents a significant global health challenge, especially in tropical and subtropical regions. The exponential increase native DENV cases Europe is concerning, indicating rise incidence. As climate change intensifies, it crucial to implement proactive measures address presence of Aedes albopictus (Asian tiger mosquito) prevent other diseases from becoming endemic temperate In 2024, Brazil experienced dramatic surge cases, reporting an...