Intrathecal (i.t.) administration of prostaglandin E 2 (PGE ) to conscious mice induced allodynia, a state discomfort and pain evoked by innocuous tactile stimuli, hyperalgesia as assessed the hot plate test. We characterized receptor subtypes (EP 1–3 involved in these sensory disorders use 7 synthetic prostanoid analogues. Sulprostone 1 < EP 3 allodynia over wide range dosages from 50 pg 5 μg kg −1 . The maximal allodynic effect was observed at min after i.t. injection, response...

This study proposes a method for creating projection images projectors in volumetric display that presents 3D by overlapping rays. Conventional methods have limited the presented to silhouettes of objects. However, generating based on back-projection Computed Tomography, it is theoretically possible project objects with internal details or figures drawn horizontal planes. In this paper, simulations were conducted using MATLAB evaluate number required present proposed method.

In order to investigate the involvement of glutamate receptor systems in allodynia induced by prostaglandin (PG) E2 or F2α, we co-administered antagonists for N-methyl-d-aspartate (NMDA). non-NMDA, metabotropic receptors intrathecally with PGE2 PGF2α and examined their effects on evoked conscious mice non-noxious brushing flanks. MK-801, a non-competitive NMDA channel blocker, d-AP-5, selective antagonist, dose-dependently blocked PGH2-induced an IC50 1.60 0.52 μg/mouse, respectively. A...

Background Glycine and gamma-aminobutyric acid (GABA) are inhibitory neurotransmitters that appear to be important in sensory processing the spinal dorsal horn. Intrathecal administration of strychnine (strychnine-sensitive glycine receptor antagonist) or bicuculline (GABAA was reported induce allodynia. Although strychnine-induced allodynia shown mediated through N-methyl-D-aspartate (NMDA)-type glutamate receptor, it is not clear whether bicuculline-evoked-allodynia system how different...

We recently reported that intrathecal (i.t.) administration of prostaglandin (PG) E2 or PGF2 alpha in conscious mice induced allodynia through a pathway includes the glutamate receptor system. Allodynia by PGE2 and was blocked antagonists for NMDA metabotropic subtypes, respectively. In present study, we examined possibility involvement nitric oxide (NO) PG-evoked allodynia. assessed once every 5 min light stroking flank with paintbrush. Intrathecal L-arginine, substrate synthase (NOS),...

Public access defibrillation has been introduced to improve the outcome of patients experiencing out-of-hospital cardiac arrest (OHCA). The aim this study was examine best location for automated external defibrillators (AED).All who were resuscitated after OHCA by emergency medical technicians in Takatsuki City over 6 years enrolled. annual incidence and number 1-year survivors with good neurological each 21 sub-location categories investigated, as well ratio ventricular fibrillation (VF)...

We recently demonstrated that intrathecal administration of prostaglandin E 2 (PGE ) and PGF 2α induced allodynia through a pathway includes the glutamate receptor nitric oxide (NO)‐generating systems from pharmacological studies. In order to clarify involvement NO in prostaglandin‐induced allodynia, we measured released rat spinal cord slices by chemiluminescence method. PGE stimulated release both dorsal ventral regions all along cord. within 10 min increased it time‐dependent manner. The...

Objective This study aimed to test the hypothesis that i-gel supraglottic airway device would fit larynx and provide better sealing pressure if prewarmed 42°C relative kept at room temperature in non-paralysed, sedated patients. Methods A total of 74 adult patients were assigned warm (i-gel 42°C; W group; 37 patients) or control temperature; C groups. Anaesthesia was induced with propofol fentanyl. The for 30 min before insertion group, but (approximately 23°C) group. number attempts made...

Intrathecal (i.t.) administration of prostaglandin E 2 (PGE ) to conscious mice was reported induce allodynia, a state discomfort and pain evoked by innocuous tactile stimuli through receptor subtype EP 1 hyperalgesia subtypes and/or 3 . In the present study, we investigated effects an antagonist on these sensory disorders use ONO‐NT‐012 or AH6809. dose‐dependently antagonized PGE ‐induced allodynia but had no effect hot plate test. On other hand, AH6809 blocked at highest dose examined (50...

In this paper, we propose a simple dynamic image position adjustment method for high-resolution displays in glassless three-dimensional (3D) viewing systems. Glassless stereoscopic are currently used many fields, however, accurately adjusting their physical display is difficult, especially given large area. Our proposed effects of the positions images on to match various conditions 3D displays. We constructed system using and lenticular lens. Experimental results confirmed that our can...

Virtual force sensation is a virtual-perception of through illusion. It can be generated by applying asymmetric vibration to the human skin using an actuator. The accuracy virtual perception decreases as presentation direction increases. In this study, momentarily in opposite just before desired direction. Then improved

Walking through real space and moving virtual is one of the methods to improve immersive experience VR content. However, available for movement in a environment limited by size space. As result, content may be compromised. One solution this problem Redirected (RDW). RDW method that allows walking on large rather than In method, rotated create illusion direction. Previous research has shown presentation tactile sensation traction increases degree illusion. study we propose technique combined...

症例は61歳の男性。3年前にKlebsiella pneumoniaeを起因菌とした肝膿瘍の既往があった。発熱と全身倦怠感を主訴に他院に救急搬送され，精査の結果，肝膿瘍による敗血症，播種性血管内凝固症候群と診断され当センターへ転院となった。腹部超音波検査，腹部造影CT検査所見では，肝外側区域に隔壁を伴う膿瘍形成を認め，抗菌薬（BIPM）の投与を開始した。第2病日に呼吸状態が悪化したため，気管挿管し人工呼吸器管理を開始するとともに超音波ガイド下経皮経肝的膿瘍ドレナージ術を行った。ドレーン造影を行うと，蜂巣状の膿瘍とそれに連続して胆管が造影された。穿刺液細菌培養の結果，Klebsiella...