A5055987122- Stress Responses and Cortisol
- Medication Adherence and Compliance
- Antibiotics Pharmacokinetics and Efficacy
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Hydrogels: synthesis, properties, applications
- Analytical Methods in Pharmaceuticals
- Pharmaceutical Practices and Patient Outcomes
- Neuroscience of respiration and sleep
- Salivary Gland Disorders and Functions
- Natural product bioactivities and synthesis
- Sleep and Wakefulness Research
- Antibiotic Use and Resistance
- Cardiac Health and Mental Health
- Meningioma and schwannoma management
- Advanced Drug Delivery Systems
- Cardiovascular Health and Disease Prevention
- Anesthesia and Sedative Agents
- Synthesis and biological activity
- Tuberculosis Research and Epidemiology
- 3D Printing in Biomedical Research
Grigore T. Popa University of Medicine and Pharmacy
2016-2025
Institute for Diagnosis and Animal Health
2024
Clinical Emergency Hospital Bucharest
2024
Sapienza University of Rome
2015
University of Oulu
2007
Background/Objectives: Epilepsy is a complex neurological disorder with strong link to oxidative stress, which contributes seizure susceptibility and neuronal damage. This study aims investigate the effects of curcumin (Cur), sodium valproate (VPA), mitocurcumin (MitoCur), mitochondria-targeted curcumin, on behavioral stress parameters in zebrafish model pentylenetetrazole (PTZ)-induced seizures. Methods: Adult were exposed two concentrations (0.25 0.5 µM for Cur MitoCur; 0.25 mM VPA)....
One major challenge in drug development is defining of the optimal animal species to serve as a model metabolism man. The study compared hepatic characteristics humans and six widely used experimental species. Classical vitro enzyme assays with known human cytochrome P450 (CYP) selectivity were employed optimized target CYP forms. profile activities best resembling was seen mouse followed by monkey, minipig, dog liver microsomes, rats displaying most divergent. widest interindividual...
Medication non-adherence is associated with almost 200,000 deaths annually and €80–125 billion in the European Union. Novel technological advances (smart pill bottles, digital inhalers spacers, electronic blisters, e-injection pens, e-Health applications, big data) could help managing non-adherence. Healthcare professionals seem however inadequately informed about non-adherence, availability of solutions daily practice limited, collaborative efforts to push forward their implementation are...
Biopolymers have gained significant attention as a class of polymer materials with wide range applications, especially in the medical and pharmaceutical field. Due to particular characteristics, such biocompatibility, biodegradability, non-toxicity, functionality, they become promising candidates for various surgical including bioadhesives, sealants, wound dressings, sutures, drug carriers, coating materials, etc. Recent research shows that further modification biopolymers by advanced...
Background/Objectives: Vancomycin is a reserve antibiotic that frequently prescribed for central venous catheter (CVC)-associated infections in hemodialysis patients. Hemodialysis patients are very fragile and the presence of CVCs increases risk sepsis. We conducted prospective study, evaluating needs changes vancomycin dosing treatment based on use new 2020 guidelines, to increase drug safety (preventing subtherapeutic or supratherapeutic doses offering therapeutic concentrations drug)...
Many patients are not taking their medicines. It has substantial negative medical and economic consequences for healthcare systems but there is limited knowledge on how medication adherence integrated in education. This study seeks to investigate what extent students medicine, pharmacy nursing Europe taught about adherence. A cross-sectional online survey was distributed 731 persons teaching relevant courses across 142 European universities between February June 2024. The addressed...
Functional capacity (FC), ideally determined by a cardiopulmonary exercise test (CPET), is valuable prognostic marker in chronic coronary syndrome (CCS). As CPET has limited availability, biomarkers of inflammation and/or fibrosis could help predict diminished FC. Our objective was to assess the value galectin-3 (gal-3) and that three inflammatory markers easily obtained from complete blood count (NLR (neutrophil-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio) MLR...
All acute and chronic wound management strategies have limitations. Therefore, there is an urgent need to develop new treatment options for healing. Hydrogels based on natural polymers offer advantages in because they can reduce patients’ pain, fight infection, carry targeted drugs speed up the healing process. In this study, we aimed investigate alginate-grafted N-vinylcaprolactam-based matrix a modified release of dexketoprofen (DEX), which potentially useful Free radical polymerization...
Background and Objectives: Functional capacity (FC) assessed via cardiopulmonary exercise testing (CPET) is a novel, independent prognostic marker for patients with coronary artery disease (CAD). Neutrophil to lymphocyte ratio (NLR) platelet (PLR) are two readily available predictors of systemic inflammation cardiovascular event risk, which could be used as cost-effective poor FC. The purpose this study was evaluate the utility NLR PLR in predicting FC CAD recent elective percutaneous...
Mitocurcumin (a triphenylphosphonium curcumin derivative) was previously reported as a selective antitumoral compound on different cellular lines, well potent bactericidal candidate. In this study, the same showed strong antimicrobial efficacy against strains of methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentration identical for all tested (four MRSA and one strain methicillin-sensitive aureus), suggesting new mechanism action compared with usual...
This study investigates the combined treatment of secukinumab (SECU) and magnolol (MAGN) in a mouse model LPS-induced ALI overlapped with allergic pulmonary inflammation, aiming to better understand mechanism behind this pathology assess therapeutic potential novel approach addressing severity ALI. The reveals intricate immunomodulatory effects. Both treatments inhibit IL-17 promote M2 macrophage polarization, which enhances anti-inflammatory cytokine production such as IL-4, IL-5, IL-10,...
Introduction: Medication non-adherence negatively affects the effectiveness of evidence-based therapies and sustainability healthcare systems. Lack agreed terminology medication adherence enabling supporting activities leads to underuse available tools. The ENABLE COST Action was aimed at proposing a new for these in order help both scientific research its clinical application. Methods: Initial discussions within Working Groups allowed conceptualization four interlinked terms related...
ABSTRACT Mixed‐interpenetrated polymeric networks based on sodium alginate (ALG) and poly( N ‐isopropylacryl amide) (PNIPAAm) covalently cross‐linked with N,N' ‐methylenebisacrylamide are studied for their biocompatibility, nontoxicity, biodegradability aiming application in drug delivery. The presence of drug‐polymeric matrix interactions the distribution network theophylline‐loaded ALG/PNIPAAm hydrogels also investigated by spectroscopic microscopic methods. quantitative evaluation...