A5085235764- Obstructive Sleep Apnea Research
- Cardiac Health and Mental Health
- Liver Disease Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Hepatitis C virus research
- Cancer, Lipids, and Metabolism
- Heart Rate Variability and Autonomic Control
- Diet, Metabolism, and Disease
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
Grigore T. Popa University of Medicine and Pharmacy
2001-2025
Clinical Emergency Hospital Bucharest
2022-2023
Infectious Diseases Institute
2020-2023
Functional capacity (FC), ideally determined by a cardiopulmonary exercise test (CPET), is valuable prognostic marker in chronic coronary syndrome (CCS). As CPET has limited availability, biomarkers of inflammation and/or fibrosis could help predict diminished FC. Our objective was to assess the value galectin-3 (gal-3) and that three inflammatory markers easily obtained from complete blood count (NLR (neutrophil-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio) MLR...
Background and Objectives: Functional capacity (FC) assessed via cardiopulmonary exercise testing (CPET) is a novel, independent prognostic marker for patients with coronary artery disease (CAD). Neutrophil to lymphocyte ratio (NLR) platelet (PLR) are two readily available predictors of systemic inflammation cardiovascular event risk, which could be used as cost-effective poor FC. The purpose this study was evaluate the utility NLR PLR in predicting FC CAD recent elective percutaneous...
Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse, chronic hypoxia and a proinflammatory phenotype. The purpose of our study was to evaluate readily available inflammatory biomarkers (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), red distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), mean platelet volume (MPV), WBC-to-MPV (WMR) lymphocyte-to-C-reactive (LCR)) before...
Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing detrimental vascular remodeling. Arterial is increasingly acknowledged as major cardiovascular risk factor marker of subclinical hypertension-mediated organ damage. The...
Chronic inflammation plays an essential role in the pathophysiology of both arterial hypertension (HTN) and coronary artery disease (CAD), is more pronounced individuals with a non-dipper circadian blood pressure (BP) pattern. A non-dipping BP pattern turn associated increased cardiovascular morbi-mortality, higher risk atherosclerotic events. Neutrophil to lymphocyte ratio (NLR), monocyte (MLR) platelet (PLR) are readily available predictors systemic risk. The purpose our study evaluate...
Background and Objectives: Obstructive sleep apnea (OSA) is associated with daytime somnolence, cognitive impairment high cardiovascular morbidity mortality. Obesity, comorbidities, accelerated erythropoiesis muscular mitochondrial energetic dysfunctions negatively influence exercise tolerance in moderate-severe OSA patients. The cardiopulmonary testing (CPET) offers an integrated assessment of the individual's aerobic capacity helps distinguish main causes limitation. purpose this study to...
Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk, sedentarism, depression, anxiety and impaired quality of life. The long-term effectiveness positive airway pressure (PAP) insufficiently studied limited by poor patient compliance. aim this pilot prospective cohort study was to evaluate adherence in overweight patients moderate-severe OSA hypertension analyze changes weight, sleepiness We performed a that included who had not undergone previous PAP therapy. All...
The aim of this observational study was to describe the characteristics and outcomes coronavirus disease 2019 (COVID-19)-positive patients with ST-segment elevation myocardial infarction (STEMI), a special focus on factors associated high risk coronary thrombosis in-hospital mortality. Comparing two groups STEMI separated according presence SARS-CoV-2 infections, it observed that COVID-19 were more likely present dyspnea (82.43% vs. 61.41%, p = 0.048) cardiogenic shock (10.52% 5.40%, 0.012)....
Background and Objectives: Non-alcoholic fatty liver disease is a worldwide significant public health problem, particularly in patients with type 2 diabetes mellitus. Identifying possible risk factors for the mandatory better understandingand management of this condition. Patatin-like phospholipase domain-containing protein 3 (PNPLA3) has been linked to development evolution but not insulin resistance. The aim study isto evaluate relationships between PNPLA3 liver, metabolic syndrome...
Obstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing, exhibiting an increasing prevalence and several cardiovascular complications. Continuous positive airway pressure (CPAP) gold-standard treatment for moderate-severe OSA, but it associated with poor patient adherence. We performed a prospective study that included 57 patients newly diagnosed prior to CPAP initiation. The objective our was assess impact short-term on ventricular function in OSA cardiometabolic...
(1) Background: Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder characterized by elevated levels of low-density lipoprotein cholesterol (LDL) that develops deposits lipids in the arterial wall. Since it underdiagnosed and undertreated, disease has high risk premature cardiovascular death. Patients are not always aware changes they should make their diet. Thus, our study aimed to evaluate through food frequency questionnaire eating habits. (2) Methods: We included...
Cardiopulmonary exercise testing (CPET) has become the golden standard in assessment of capacity and intensity patients who are performing cardiac rehabilitation. The purpose our study was to objectify relationships between parameters CPET lipid profile after cardiovascular We found a significant increase oxygen consumption (VO2) values, anaerobic threshold, effort maximum heart rate an improvement profile, marking reduced risk.
The association between chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MetS) is a common one, with long-term therapeutic prognostic impact. In view of the high cardiovascular morbidity mortality, self-management contributes to decreasing risk an acute cardiac event or decompensation.
Abstract Introduction . Non-alcoholic fatty liver disease (NAFLD) is regarded as the hepatic expression of metabolic syndrome, both conditions presenting similar clinical features. Aim The aim this study was to evaluate, among diabetic subjects, relationship between load and presence syndrome criteria. Methods An observational conducted on 92 subjects with type 2 diabetes. We followed anthropometric measurments, lipid profile, blood pressure degree steatosis using ultrasonography. Results...
Obstructive sleep apnea (OSA) is the most common type of disordered breathing, with a signifi cant impact on health-related quality life (HR-QoL).Continuous positive airway pressure (CPAP) gold-standard treatment for moderate-severe OSA, but associated poor patient compliance (due to fi nancial issues and frequent side eff ects).The purpose this study evaluate HR-QoL among patients OSA from North-Eastern Romania, at baseline after 2 months CPAP.75 were initially included in our only 59...
(1) Background: Familial hypercholesterolemia (FH) is a genetic disease that has autosomal dominant inheritance, being characterized by increased levels of low-density lipoproteins (LDLs) due to decreased clearance the circulant LDLs. Alimentation key factor in patients with FH. Implementing restrictive diet may have significant impact on their quality life, besides social and environmental factors. (2) Methods: We realized prospective study was conducted Cardiovascular Rehabilitation Clinic...