A5046802784- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Respiratory viral infections research
- Drug-Induced Adverse Reactions
- Inflammatory mediators and NSAID effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Contact Dermatitis and Allergies
- Air Quality and Health Impacts
- Xenotransplantation and immune response
- Climate Change and Health Impacts
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Sinusitis and nasal conditions
- Pancreatic function and diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
Instituto Nacional de Enfermedades Respiratorias
2015-2024
Universidad Nacional Autónoma de México
2021-2024
National Institute of Genomic Medicine
2010-2018
GTx (United States)
2017
University of Fribourg
2014
University of Southern California
2000-2008
Hospital Infantil de México Federico Gómez
2004-2007
Pontificia Universidad Católica de Chile
2004
University of Southampton
1993-2000
Kiel University
1996-2000
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Eosinophils (Eos) and fibroblasts are known to play a major role in the pathogenesis of bronchial asthma fibrotic lung disease. Therefore, we investigated whether Th1 Th2 cytokines stimulate production Eo-activating chemokines by fibroblasts. Analyses culture supernatant using multiple steps high-performance liquid chromatography demonstrated that interleukin (IL)-4 preferentially stimulates secrete peak eosinophil chemotactic activity (ECA) which, upon N-terminal analyses, showed similar...
Objective : Porcine islets of Langerhans for xenotransplantation into humans have been proposed as a solution to the shortage human donors. Rejection is one main constraints. This study presents results clinical trial using novel method transplanting and immunoprotecting porcine in type 1 diabetic patients. Design A 4-year follow up involving 12 patients, with no immunosuppressive drugs at any point. Eleven age matched untransplanted diabetics served controls. Methods We developed procedure...
As the U.S. becomes increasingly multicultural, traditional values from various cultures will influence health-related attitudes and behaviors for a greater number of adolescents in Unfortunately, few scales exist to measure cultural influences on adolescent health behaviors. This study developed Multiethnic Cultural Values Scale assess some beliefs relevant In multiethnic sample 211 California adolescents, associations between substance use were examined. Filial piety familism associated...
We have investigated the presence of regulated on activation, normal T-cell expressed and probably secreted (RANTES), macrophage inflammatory peptide-1 α (MIP-1 ), chemotactic peptide (MCP-1) in bronchoalveolar lavage fluid (BALF) obtained from (n = 7) stable asthmatic subjects 8), studied their kinetic release into airways following endobronchial allergen challenge 18). Measurements RANTES, MIP-1 , MCP-1 10 times (10 × ) concentrated BALF showed that these three chemokines were present both...
Neutrophil infiltration is a major feature in the pathogenesis of common cold, and respiratory viral infection cause asthma exacerbations. The factors regulating neutrophil influx are unknown. Interleukin-8 (IL-8) potent chemoattractant, which has been implicated several inflammatory diseases. In this study, we investigated presence IL-8 chemokine nasal aspirates asthmatic children (n = 12) whom was precipitated by proven infection. There were increased levels from during virus-induced...
Accumulation of CD4+ interleukin (IL)-2R+ lymphocytes in the airways asthmatics is generally attributed to presence chemoattractant cytokines. The precise mechanism for initiation earliest lymphocyte infiltration and activation unknown. In this study, we describe first time activity bronchoalveolar lavage (BAL) fluid obtained from 6 h after antigen challenge. majority at early point represented by IL-16 (lymphocyte factor), a cell-specific growth factor. addition IL-16, macrophage...
Purpose: To evaluate the association between allergic sensitivity and pollen counts in patients with respiratory disease (ARD) its relationship atmospheric pollutants. Methods: From 2012 to 2018, we evaluated by skin prick test ARD patients. The were analyzed according international guidelines (2014– 2018). pollutant meteorological data obtained at same time from AIRE-CDMX websites. We using χ 2 stratified rhinitis (AR) AR asthma (ARwA), periods (before/after 2015), pollination seasons...
Eosinophil infiltration of the airways in response to allergen exposure is a characteristic bronchial asthma. However, mechanisms by which these cells are recruited poorly understood. We have investigated presence eosinophil chemotactic activity (ECA) bronchoalveolar lavage fluid obtained from allergic asthmatics (n = 6) 4 h after endobronchial challenge. ECA was purified sequential heparin affinity chromatography and reverse-phase HPLC. A single peak detected; SDS-PAGE Western blot analysis...
Short-term exposure to ozone at peak ambient levels induces neutrophil influx and impairs lung function in healthy humans. In order investigate the mechanisms contributing recruitment examine role of T-cells acute inflammatory response, we exposed 12 humans 0.2 parts per million (ppm) filtered air on two separate occasions for 2 h with intermittent periods rest exercise (minute ventilation = 30 L x min(-1)). Fibreoptic bronchoscopy was performed 6 after end exposures. Total protein,...
This study assessed the heterogeneity of cytokine expression in asthma before and after local allergen challenge.BAL T cells were obtained 10 min or 24 h endobronchial challenge atopic asthmatic subjects. cloned by direct limiting dilution. mRNA was RT-PCR, protein production ELISA.Unstimulated baseline BAL expressed for IFN-gamma, IL-13, TNF-alpha. A minority samples IL-4 IL-5, but no IL-3 detected. PHA stimulation increased IL-3, IL-4, IL-5 4/6 samples. IL-13 GM-CSF found challenge,...
Interleukin (IL)-5 is a pleiotropic cytokine that exhibits biologic activity on cells of diverse hemopoieitic lineages. IL-5 enhances mediator release from human basophils and plays pivotal role in the chemoattraction, proliferation, differentiation, survival, activation eosinophils. Th2- Tc2-like T cells, mast basophils, eosinophils are known cellular sources this cytokine. Using sensitive novel reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay system, we...
The presence of cytokines and the toxic eosinophil granule product major basic protein (MBP) was investigated in nasal aspirates from children with naturally occurring virus-induced asthma exacerbations compared levels taken same when asymptomatic. Increased MBP accompanied by increased chemokines RANTES macrophage-inhibitory 1alpha were observed during exacerbations. Granulocyte-macrophage colony-stimulating factor mostly undetectable samples obtained both symptomatic asymptomatic periods....