A5102851710- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Multicomponent Synthesis of Heterocycles
- Nanoparticle-Based Drug Delivery
- Oxidative Organic Chemistry Reactions
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Organic and Inorganic Chemical Reactions
- Nanoplatforms for cancer theranostics
- DNA Repair Mechanisms
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Lanthanide and Transition Metal Complexes
- Radical Photochemical Reactions
- Radiation Therapy and Dosimetry
- Catalytic C–H Functionalization Methods
- Radiopharmaceutical Chemistry and Applications
- Synthesis and Catalytic Reactions
- Organoselenium and organotellurium chemistry
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Effects of Radiation Exposure
- Gold and Silver Nanoparticles Synthesis and Applications
- Click Chemistry and Applications
Sichuan University
2022-2024
Gansu Provincial Cancer Hospital Gansu Provincial Academic Instiute for Medical Research
2011-2023
Academy of Medical Sciences
2011-2023
Nanjing Agricultural University
2021-2022
State Council of the People's Republic of China
2021
Lanzhou City University
2018-2021
Gansu Academy of Sciences
2009-2020
Gansu Provincial Hospital
2012-2018
Zhejiang University of Technology
2004-2018
Soochow University
2017
Inspired by marine mussel adhesive proteins, polymers with catechol side groups have been extensively explored in industrial and academic research. Here, Pluronic L-31 alcoholate ions were used as the initiator to prepare a series of polypeptide–Pluronic–polypeptide triblock copolymers via ring-opening polymerization l-DOPA-N-carboxyanhydride (DOPA-NCA), l-arginine-NCA (Arg-NCA), l-cysteine-NCA (Cys-NCA), ε-N-acryloyl lysine-NCA (Ac-Lys-NCA). These demonstrated good biodegradability,...
[reaction: see text] Under very mild conditions, functionalized 2-(sulfonylimino)-4-(alkylimino)azetidine derivatives were prepared in good to excellent yields via a copper-catalyzed multicomponent reaction of readily available terminal alkynes, sulfonyl azides, and carbodiimides without the assistance base. The mechanism may be through [2 + 2] cycloaddition.
In this study, thermoresponsive and mussel-inspired polypeptides were synthesized using ring-opening polymerization of α-amino acid derivatives N-carboxyanhydride (NCA). The tissue adhesive properties these evaluated in vitro strength tests on porcine skin bone. results indicated that the species functional polypeptide side groups temperature have a significant influence adhesion strength. maximum lap-shear was 101.2 kPa, tensile bone 603 kPa. vivo antibleeding activity ability also rat...
The introduction of new treatments for esophageal cancer including surgery, chemotherapy, radiotherapy, or a combination these modalities has not only improved patient survival, but may also increase the risk second primary cancers. available evidence is conflicting with most estimates based on sparse numbers. Here we estimated standardized incidence ratios (SIRs) among 24,557 survivors (at least 2 months) in Surveillance, Epidemiology, and End Results (SEER) Program between 1973 2007, who...
Several assays have been frequently used to estimate antioxidant capacities including<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mtext>ABTS</mml:mtext></mml:mrow><mml:mrow><mml:mo>•</mml:mo><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>, DPPH, and FRAP assays. Xanthohumol (XN), the major prenylated flavonoid contained in beer, witnessed various reports on its capacity. We systematically evaluated activity of XN using...
Ruthenium catalyst TpRuPPh3(CH3CN)2Cl is found to effect the cyclization of epoxyalkynes furans in presence Et3N. The reactions worked well for various with suitable oxygen and nitrogen functionalities low loading catalyst. It failed disubstituted epoxyalkynes. mechanism was elucidated by a deuterium labeling experiment that suggested involved ruthenium−vinylidenium intermediate.
Abstract Functionalized propiolamidine derivatives were prepared in good to excellent yields under very mild conditions via a copper‐catalyzed multicomponent reaction (MCR) of readily available terminal alkynes, acid chlorides and carbodiimides with the assistance triethylamine. The mechanism this MCR is postulated.
Abstract A basic ionic liquid, 1‐butyl‐3‐methyl imidazolium hydroxide ([bmim]OH), efficiently promotes a one‐pot, three‐component condensation of aromatic aldehydes, malononitrile or ethyl cyanoacetate, and 2‐hydroxy‐1,4‐naphthoquinone to produce 4‐aryl‐5,10‐dihydro‐4 H ‐benzo[ g ]chromene‐5,10‐dione derivatives in high yields at room temperature. This reaction does not involve any hazardous organic solvent toxic catalyst. The liquid is recovered recycled for subsequent reactions. Moreover,...
Transcatheter arterial embolization (TAE) has been widely applied in treatments of unresectable or hypervascular tumors, but the procedure TAE is complicated possibly brings inherent risks. Here, inspired by pH-responsive drug delivery systems, a new method noninvasive and target therapy intravenous injection was developed. This based on type acidic microenvironment-responsive hyperbranched poly(amino acid) (HPTTG) to avoid using catheterization real-time image guidance angiography,...
Tumor theranostics hold great potential for personalized medicine in the future, and transcatheter arterial embolization (TAE) is an important clinical treatment unresectable or hypervascular tumors. In order to break limitation, simplify procedure of TAE, achieve ideal combinatorial theranostic capability, here, a kind triblock-polypeptide-coated perfluoropentane-loaded mesoporous Fe3O4 nanocomposites (PFP-m-Fe3O4@PGTTCs) were prepared non-interventional target-embolization, magnetic...
Heterogeneous electro-Fenton is one of the promising technologies to degrade refractory organic phosphonates. In this work, CoNWs@CoAl-LDHs/Fe3O4 and CoNPs@CoAl-LDHs/Fe3O4 were successfully synthesized by a co-precipitation method applied 1-hydroxyethane-1,1-diphosphonic acid (HEDP) glyphosate (PMG) via an process. The results indicated that removal rate HEDP (100 mg L-1) PMG increased from 62.09% 95.31% 82.45% 100%, respectively. system could remove 70.03% nearly 100% within 2 hours at pH...
Skeletal muscle is a major organ in animals, which constitutes over 40% of livestock body weight, and plays critical role metabolism homeostasis an organism. Autophagy apoptosis are two processes to determine cell fate. Recently, the importance autophagy myogenesis has been identified; however, their crosstalk not well defined. In this study, we aimed explore relationship between during myogenic differentiation. The results showed that level was consistent with increased activated autophagy,...
Ionizing radiation exposure is associated with a risk of cardiac fibrosis; however, the underlying molecular mechanism remains unclear. Growth/differentiation factor-15 (GDF15), fibroblast factor, divergent member transforming growth factor β superfamily. Next-generation sequencing analyses has revealed that Gdf15 increased in fibroblasts during radiation-induced fibrosis. However, role fibrosis In this study, we demonstrated upregulated expression GDF15 newborn rat and adult rats after...
Water-in-oil (W/O) emulsions were designed for improved storage of the biolarvacide Lagenidium giganteum (Oömycetes: Lagenidiales). Hydrophobicly treated silica nanoparticles investigated stabilizing cells. Increasing concentration significantly reduced cell death rate, particularly in formulations with a high initial density. Experiments also done NaCl and L. formulated same emulsion to examine ability oil sequester cells during storage. Such sequestration would allow combined formulation,...