A5081737664- Ocular Surface and Contact Lens
- Genetics and Neurodevelopmental Disorders
- interferon and immune responses
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Pharmacovigilance and Adverse Drug Reactions
- Drug-Induced Hepatotoxicity and Protection
- Advanced Glycation End Products research
- Retinal Diseases and Treatments
- Drug-Induced Ocular Toxicity
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Cardiovascular Syncope and Autonomic Disorders
- Ocular Diseases and Behçet’s Syndrome
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Natural Compounds in Disease Treatment
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Neurological diseases and metabolism
Xiamen University
2023-2024
First People's Hospital of Yunnan Province
2024
Eye Center
2023
XinHua Hospital
2021-2022
Shanghai Jiao Tong University
2022
Abstract The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. epithelium central response, but whether and how immunity initiated by epithelial cells in various stresses diseases, such as dry eye, still unclear. By utilizing two classic experimental eye models—a mouse treated with benzalkonium chloride (BAC) a model surgically removed extraorbital lachrymal glands, well patient samples—along human corneal...
Genome sequencing (GS) has been used in the diagnosis of global developmental delay (GDD)/intellectual disability (ID). However, performance GS patients with inconclusive results from chromosomal microarray analysis (CMA) and exome (ES) is unknown. We recruited 100 pediatric GDD/ID multiple sites China February 2018 to August 2020 for GS. Patients have received at least one genomic diagnostic test before enrollment. Reanalysis their CMA/ES data was performed. The yield calculated...
Abstract Dry eye affects majority of the global population, causing significant discomfort or even visual impairment, which inflammation plays a crucial role in deterioration process. This highlights need for effective and safe anti‐inflammatory treatments to achieve satisfactory therapeutic outcomes. study focuses on potential tetrahedral framework nucleic acids (tFNA), self‐assembled acid material, as simple rapid treatment oxidative stress inflammation‐induced disorders associated with...
Abstract Background Neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV) is a rare autosomal dominant syndrome, which caused by the heterozygous germline loss‐of‐function variants in CTNNB1. Methods We evaluated clinical genetic findings of 24 previously undescribed Chinese patients affected CTNNB1 ‐related disorders explored possible ethnicity‐related phenotypic variations. Results Twenty‐one were identified within these NEDSDV patients, including 14 novel 7...
This study aimed to assess the drug risk of drug-related keratitis and track epidemiological characteristics keratitis.
Abstract Background This study aims to assess the risk of drug‐associated glaucoma and track its epidemiological characteristics using real‐world data. Methods Adverse event reports from Food Drug Administration Event Reporting System (FAERS) January 2004 December 2023 were analysed. Disproportionality analysis Bayesian Confidence Propagation Neural Network algorithm used. The classified drugs associated with glaucoma, assessed levels, compared drug‐induced times across different categories....
Retinal neovascularization (RNV), a major cause of blindness, is treated with anti-VEGF drugs. Despite successes, incomplete patient responses push for alternative strategies. In this study, combined approach was devised by conjugating exosomes (Exo) derived from adipose mesenchymal stromal cells (ADMSCs) specially designed peptides called KAI, using cleavable linker controlled matrix metalloproteinases (MMPs). This allowed an environmentally responsive release the peptide Exo. Intravitreal...
Ischemic retinopathies (IRs) are vision-threatening diseases that affect a substantial amount of people. The current treatment options for IRs have side effects and unable to prevent disease progression. It is therefore worthwhile consider alternative treatments could be safer more efficient. Icariside II (IRS) metabolite icariin, derived from traditional Chinese medicine Herba Epimedii. In the oxygen-induced retinopathy (OIR) model, IRS significantly inhibited pathological angiogenesis...
Retinal neovascularization is a leading cause of blindness. While current anti-VEGF drugs effectively inhibit pathological angiogenesis, some patients develop resistance or reduced responsiveness to treatments over time, diminished effectiveness. In this study, we identified high activation the cGAS-STING signaling pathway, which exacerbated and vessel leakage. We developed an injectable thermo-responsive supramolecular hydrogel loaded with anti-STING drug. The hydrogel, made Pluronic F127...
Genome sequencing(GS) has been applied in the diagnosis of global developmental delay(GDD)/intellectual disability(ID). However, performance those with inconclusive results from chromosomal microarray analysis(CMA) and exome sequencing(ES) is unknown. We recruited 100 pediatric GDD/ID patients multiple sites China February 2018 to August 2020 for GS. Patients have received at least one genomic diagnostic test prior enrollment. Reanalysis CMA/ES data was performed. The yield GS calculated...