A5046804560- Geological and Geochemical Analysis
- High-pressure geophysics and materials
- earthquake and tectonic studies
- Geochemistry and Geologic Mapping
- Genomics and Rare Diseases
- Ubiquitin and proteasome pathways
- Genomic variations and chromosomal abnormalities
- Hydrocarbon exploration and reservoir analysis
- Paleontology and Stratigraphy of Fossils
- Geochemistry and Elemental Analysis
- Methane Hydrates and Related Phenomena
- Genetics and Neurodevelopmental Disorders
- Geological and Geophysical Studies
- RNA modifications and cancer
- RNA Research and Splicing
- Geology and Paleoclimatology Research
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Genetic Syndromes and Imprinting
- Chromosomal and Genetic Variations
- Heat shock proteins research
- Congenital limb and hand anomalies
- Curcumin's Biomedical Applications
- Retinoids in leukemia and cellular processes
- Coal Properties and Utilization
Hohai University
2017-2025
East China University of Technology
2025
XinHua Hospital
2018-2023
Shanghai Jiao Tong University
2018-2023
First Institute of Oceanography
2022
Ministry of Natural Resources
2022
Qingdao National Laboratory for Marine Science and Technology
2020
Chinese Academy of Sciences
2016
Beijing Institute of Geology for Mineral Resources
2014-2016
Soochow University
2014-2016
The West Kunlun orogenic belt (WKOB) along the northern margin of Tibetan Plateau is important for understanding evolution Proto- and Paleo-Tethys oceans. Previous investigations have focused on igneous rocks ophiolites distributed mostly Xinjiang-Tibet road China-Pakistan road, constructed a preliminary tectonic model this belt. However, few studies so-called Precambrian basement in area. As result, affinity individual terranes WKOB their detailed process are uncertain. Here we report new...
// Lixia Wang 1, * , Xiantao Ye Xingming Cai 2, Jingna Su 1 Renqiang Ma 3 Xuyuan Yin Xiuxia Zhou Huabin Li Zhiwei The Cyrus Tang Hematology Center and Collaborative Innovation of Hematology, Jiangsu Institute First Affiliated Hospital, Soochow University, Suzhou, China 2 Department Geriatrics, Hospital Sun Yat-sen Guangzhou, ENT, Head Neck Surgery, These authors have contributed equally to this work Correspondence to: Wang, e-mail: zwang6@bidmc.harvard.edu Li, allergyli@163.com Keywords:...
Abstract STUDY QUESTION Is the sperm acrosome membrane-associated protein 1 (SPACA1) gene critical to human globozoospermia? SUMMARY ANSWER The biallelic loss-of-function (variant of SPACA1) causes globozoospermia as a result acrosome–acroplaxome complex damage. WHAT IS KNOWN ALREADY SPACA1 expression decreases in patients with globozoospermia. Spaca1 gene-disrupted mice have abnormally shaped heads that resemble those DESIGN, SIZE, DURATION We recruited consanguineous family two brothers...
Genome sequencing (GS) has been used in the diagnosis of global developmental delay (GDD)/intellectual disability (ID). However, performance GS patients with inconclusive results from chromosomal microarray analysis (CMA) and exome (ES) is unknown. We recruited 100 pediatric GDD/ID multiple sites China February 2018 to August 2020 for GS. Patients have received at least one genomic diagnostic test before enrollment. Reanalysis their CMA/ES data was performed. The yield calculated...
Abstract Using high‐resolution remote sensing images and detailed field investigations, this study provides the spatiotemporal distribution geometry of Neoproterozoic giant mafic dyke swarm in southeastern Tarim Craton, which is crucial for reconstructing paleogeographic position Craton within Rodinia supercontinent. This extends over 600 km length 20 width, spanning more than 12,000 2 . Individual dykes ranged from 1.9 to 168 m thickness 27 2,778 length. The were emplaced at 933–914 Ma,...
// Lixia Wang 1 , Yingying Hou Xuyuan Yin Jingna Su Zhe Zhao Xiantao Ye Xiuxia Zhou Li 2 Zhiwei 1, 3 The Cyrus Tang Hematology Center and Collaborative Innovation of Hematology, Jiangsu Institute First Affiliated Hospital, Soochow University, Suzhou, China Department Gynecologic Oncosurgery, Jilin Province Cancer Changchun, Jilin, Pathology, Beth Israel Deaconess Medical Center, Harvard School, USA Correspondence to: Zhou, email: libyacynthia@163.com Wang, zwang6@bidmc.harvard.edu Keywords:...
Abstract The Set8/PR-Set7/KMT5a methyltransferase plays critical roles in governing transcriptional regulation, cell cycle progression and tumorigenesis. Although CRL4 Cdt2 was reported to regulate Set8 stability, deleting the PIP motif only led partial resistance ultraviolet-induced degradation of Set8, indicating existence additional E3 ligase(s) controlling stability. Furthermore, it remains largely undefined how DNA damage-induced kinase cascades trigger timely destruction govern Here,...
Lithosphere extension and upwelling of asthenosphere at post-collisional stage an orogenic cycle generally induce diverse magmatism and/or associated high-temperature metamorphism. Nevertheless, the intimate coexistence magmatic activity metamorphism is rare. In this contribution, a lithological assemblage composing rocks deriving from distinct magma sources coeval was identified in eastern Kunlun. Petrography, ages, mineral chemistry whole-rock geochemistry demonstrated that those...
Studies have investigated the tumor suppressive role of rottlerin in carcinogenesis. However, molecular mechanisms rottlerin-induced anti-tumor activity are largely unclear. Skp2 (S-phase kinase associated protein 2) has been validated to play an oncogenic a variety human malignancies. Therefore, inactivation could be helpful for treatment cancers. In current study, we explore whether inhibit expression, leading inhibition cell growth, migration and invasion breast cancer cells. We found...
Arsenic trioxide (ATO) has been found to exert anti-cancer activity in various human malignancies. However, the molecular mechanisms by which ATO inhibits tumorigenesis are not fully elucidated. In current study, we explored basis of ATO-mediated tumor growth inhibition pancreatic cancer cells. We used multiple approaches such as MTT assay, wound healing Transwell invasion annexin V-FITC, cell cycle analysis, RT-PCR and Western blotting achieve our goal. that treatment effectively caused...
Abstract The late Palaeoproterozoic to early Mesoproterozoic igneous rocks of southwestern China are characterized by a number mafic intrusions and dykes. However, the origin tectonic implications these dykes remain unclear. Hekou intrusion, intruding into Group in area, SW China, is biggest most representative one. intrusion mainly composed coarse-grained central zone (CZ) medium- fine-grained gabbroic outer (OZ). Cameca secondary ion mass spectroscopy (SIMS) U–Pb zircon ages, geochemical...
Abstract We report new field observations, zircon U–Pb ages and geochemical data for the discrete members of Zhaheba ophiolite complex in northeastern Junggar Central Asian Orogenic Belt (CAOB) with aim to understand accretion process eastern terrane. The age reveal that cumulates crystallized at ~485 Ma while volcanic sequences erupted ~400 Ma. Thus, are not ophiolite. Chromian spinels from serpentinite have comparable elemental compositions those MORB-type ophiolites. Similarly, rift...