A5036831878- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Lanthanide and Transition Metal Complexes
- Quantum Dots Synthesis And Properties
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Medical Imaging Techniques and Applications
Tehran University of Medical Sciences
2016-2022
Pasteur Institute of Iran
2022
Evaluating the efficacy of anticancer drugs is an evolving and research-oriented issue. The objective this study was to reduce insolubility chlorambucil (CBL) in water improve activity CBL vitro vivo through conjugation with anionic linear-globular dendrimer (second generation, G2). In current study, among three groups that include CBL, CBL-G2 dendrimer, control measured vivo. studies showed G2 polyethylene-glycol-based which conjugated exterior ester linkage, able significantly treatment...
Dendrimers are one of the most appropriate nanocaries for imaging moieties in applications.The purpose this study was evalution cytotoxicity and inducing apoptosis dendrimers. This conducted order to investigate metastasis suppression effect dendrimer human breast MCF-7 cell line finding nanoparticle protein corona biological enviromental. Dendrimer assessed by MTT assay. The mRNA experession level KAI1 as a suppressor gene, Bax Pro- apoptotic Bcl-2 an anti-apoptotic gene GAPDH housekepping...
Introduction . Breast cancer is the leading cause of mortality for women, and effort being made to provide an agent which has both imaging therapeutic effects (theranostics) can improve survival, economic burden, outcomes. Methods In this research, first time, we introduce a new magnetophotoluminescent quantum dot (Mn‐Si‐QD) capable DOX loading. Mn‐Si‐QD was synthesized evaluated by FT‐IR, UV‐Vis, fluorescence, SEM, TEM. The impacts various factors such as reaction time temperature were...
Objective(s): Early detection of cancer can significantly increase the likelihood successful treatment, and imaging assay have a significant impact on diagnosis. Although gadolinium compounds are used as contrast agent in MRI, this substance has side effects disadvantages. Nanotechnology so far had significan medical methods, especially nanoparticles enhancers that Each with its characteristics increased quality images reduced toxicity.Materials Methods: In study, novel nano-conjugate based...