A5067108842- Vibrio bacteria research studies
- Escherichia coli research studies
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Aquaculture disease management and microbiota
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Clostridium difficile and Clostridium perfringens research
- Child Nutrition and Water Access
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Monoclonal and Polyclonal Antibodies Research
- CRISPR and Genetic Engineering
- Peptidase Inhibition and Analysis
- Microbial Community Ecology and Physiology
- Infective Endocarditis Diagnosis and Management
- T-cell and B-cell Immunology
- Amino Acid Enzymes and Metabolism
- Bacterial Infections and Vaccines
- Listeria monocytogenes in Food Safety
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Howard Hughes Medical Institute
2016-2025
Boston University
2012-2025
Harvard University Press
2007-2025
Broad Institute
2009-2025
Hospitality Homes
2010-2023
South China Sea Institute Of Oceanology
2022
Institute of Oceanology
2022
Chinese Academy of Sciences
2022
A large outbreak of diarrhea and the hemolytic-uremic syndrome caused by an unusual serotype Shiga-toxin-producing Escherichia coli (O104:H4) began in Germany May 2011. As July 22, a number cases E. have been reported--3167 without (16 deaths) 908 with (34 deaths)--indicating that this strain is notably more virulent than most strains. Preliminary genetic characterization suggested that, unlike these strains, it should be classified within enteroaggregative pathotype coli.We used...
Although cholera has been present in Latin America since 1991, it had not epidemic Haiti for at least 100 years. Recently, however, there a severe outbreak of Haiti.We used third-generation single-molecule real-time DNA sequencing to determine the genome sequences 2 clinical Vibrio cholerae isolates from current Haiti, 1 strain that caused and strains isolated South Asia 2002 2008. Using primary sequence data, we compared genomes these 5 set previously obtained partial genomic 23 diverse V....
Anyone for d ? The chemistry of amino acids comes in two chirally distinct flavors—so-called l - and -enantiomers. By far the most commonly used form all kingdoms life is -form. Now Lam et al. (p. 1552 ; see Perspective by Blanke ) present unanticipated observation that diverse bacteria release large amounts various -amino into environment a population density–dependent fashion act as extracellular effectors regulate composition, structure, amount, strength peptidoglycan, major...
Shiga toxin-producing Escherichia coli (STEC) cause significant disease; treatment is supportive and antibiotic use controversial. Ciprofloxacin but not fosfomycin causes toxin-encoding bacteriophage induction enhanced toxin (Stx) production from E. O157:H7 in vitro. The potential clinical relevance of this was examined mice colonized with given either ciprofloxacin or fosfomycin. Both antibiotics caused a reduction fecal STEC. However, animals treated had marked increase free Stx,...
Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond host adrenergic signaling molecules and signals in order promote the expression of virulence factors. Using high-throughput screen, we identified small molecule, LED209, that inhibits binding preventing its autophosphorylation consequently inhibiting QseC-mediated activation gene expression. LED209 is not toxic does inhibit pathogen growth; however, this compound markedly several vitro vivo...
Vibrio cholerae O139 is the first non-O1 serogroup of V. to give rise epidemic cholera. Apparently, this new arose from an El Tor O1 strain V cholerae, but distinguishable by virtue its novel antigenic structure and also characteristic pattern resistances antibiotics sulfamethoxazole, trimethoprim, streptomycin, furazolidone. We found that three these antibiotic are carried on approximately 62-kb self-transmissible, chromosomally integrating genetic element which we have termed SXT element....
Administration of a monoclonal antibody (GK1.5) that recognizes the L3T4 marker present on helper T cells prevented development experimental allergic encephalomyelitis (EAE) in mice. Furthermore, treatment with GK1.5 reversed EAE when was given to paralyzed animals. In vivo injection selectively reduced number + spleen and lymph nodes. These results suggest manipulation human equivalent murine T-cell subset antibodies may provide effective therapy for certain autoimmune diseases.
Integrating and conjugative elements (ICEs) are one of the three principal types self-transmissible mobile genetic in bacteria. ICEs, like plasmids, transfer via conjugation; but unlike plasmids similar to many phages, these integrate into replicate along with host chromosome. Members SXT/R391 family ICEs have been isolated from several species gram-negative bacteria, including Vibrio cholerae, cause cholera, where they important vectors for disseminating genes conferring resistance...
Abstract Although the taxonomic composition of human microbiome varies tremendously across individuals, its gene or functional capacity is highly conserved — implying an ecological property known as redundancy. Such redundancy has been hypothesized to underlie stability and resilience microbiome, but this hypothesis never quantitatively tested. The origin still elusive. Here, we investigate basis for in by analyzing genomic content network a bipartite graph that links microbes genes their...
Bacteremia, a leading cause of death, generally arises after bacteria establish infection in particular tissue and transit to secondary sites. Studying dissemination from primary sites by solely measuring bacterial burdens does not capture the movement individual clones. By barcoding Klebsiella pneumoniae, bacteremia, we track pathogen following pneumonia. Variability organ is attributable two distinct patterns distinguished degree similarity between lung systemic In metastatic...