A5101876711- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Sperm and Testicular Function
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects of Natural Compounds
- Eicosanoids and Hypertension Pharmacology
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Radiomics and Machine Learning in Medical Imaging
- Nitric Oxide and Endothelin Effects
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Signaling Pathways in Disease
- Reproductive Biology and Fertility
- Ferroptosis and cancer prognosis
- Pain Management and Placebo Effect
- Anesthesia and Sedative Agents
- Lung Cancer Diagnosis and Treatment
- Nausea and vomiting management
- Neural dynamics and brain function
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shanxi Medical University
2024
National Clinical Research
2024
Henan Academy of Sciences
2024
Molecular Oncology (United States)
2024
Second Affiliated Hospital of Zhejiang University
2018-2023
First Affiliated Hospital of Zhengzhou University
2019
Lanzhou University Second Hospital
2011
Lanzhou University
2011
Nerve injury–induced changes of gene expression in dorsal root ganglion (DRG) are critical for neuropathic pain genesis. However, how these occur remains elusive. Here we report the down-regulation zinc finger protein 382 (ZNF382) injured DRG neurons after nerve injury. Rescuing this attenuates nociceptive hypersensitivity. Conversely, mimicking produces symptoms, which alleviated by C-X-C motif chemokine 13 (CXCL13) knockdown or its receptor CXCR5 knockout. Mechanistically, an identified...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide, and lymph node dissection (LND) a significant surgical procedure employed in its management. Although some studies suggest benefits LND, extent impact on survival, optimal range nodes to be examined, specific patient groups that benefit most remain areas active debate investigation.
General anesthesia is a drug-induced reversible state comprised of altered states consciousness, amnesia, analgesia, and immobility. The medial frontal cortex (mPFC) has been discovered to modulate the level consciousness through cholinergic glutamatergic pathways. optogenetic tools combined with in vivo electrophysiological recording were used study neural oscillatory modulation mechanisms mPFC underlying loss (LOC) emergence. We found that activation both neurons basal forebrain (BF)...
Opioids are the last option for pharmacological treatment of neuropathic pain, but their antinociceptive effects limited. Decreased mu opioid receptor (MOR) expression in peripheral nervous system may contribute to this. Here, we showed that nerve injury induced hypermethylation Oprm1 gene promoter and an increased methyl-CpG binding protein 2 (MeCP2) injured dorsal root ganglion (DRG). The downregulation MOR DRG is closely related augmentation MeCP2, epigenetic repressor, which could...
Neuropathic pain(NP) is a kind of chronic pain that different to the common type pain, in fact, mechanisms NP are still poorly understood. Explore genetic changes and various neurobiological could provide important diagnosis treatment tools for clinician. GSE24982 mRNA microarray dataset, we downloaded it from Gene Expression Omnibus database identify key genes NP. Differentially expressed genes(DEGs) were obtained using BRB-ArrayTools software R. Functional pathway enrichment analysis DEGs...
Objective: To study the general efficacy of hydromorphone as a systemic analgesic in postoperative pain management following single-port video-assisted thoracoscopic surgery (VATS) and to explore optimal administration regimen. Methods: A prospective, randomized, double-blind was designed conducted tertiary hospital. In total, 157 valid patients undergoing VATS were randomly allocated into three groups. total 53 received morphine bolus only for analgesia (Group Mb); 51 background infusion...
Investigating mutations, including single nucleotide variations (SNVs), gene fusions, alternative splicing and copy number (CNVs), is fundamental to cancer study. Recent computational methods biological research have demonstrated the reliability significance of detecting mutations from single-cell transcriptomic data. However, there a lack single-cell-level database containing comprehensive mutation information in all types cancer. Establishing landscape huge emerging data can provide...
Objective To investigate the effect of propofol on endothelial nitric oxide synthase (eNOS) and inducible (iNOS) expression in thoracic aorta hypertensive rats.Methods Healthy SD rats both sexes weighing 240-280 g were used this study.Hypertension was induced by subcutaneous deoxycorticosterone 25 mg/kg twice a week for consecutive 7 weeks.Sixty-four randomly divided into four groups (n ＝ 16 each):hypertension group (group H),low,medium high dose ( P1,P2,P3 ).Groups P1,P2 P3 received...