A5028879920- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Inflammation biomarkers and pathways
- IL-33, ST2, and ILC Pathways
- Clinical Nutrition and Gastroenterology
- Digestive system and related health
- ATP Synthase and ATPases Research
- Respiratory viral infections research
- Parasites and Host Interactions
- Eosinophilic Esophagitis
University of Liège
2017-2024
Abstract Macrophage polarization is a process whereby macrophages acquire distinct effector states (M1 or M2) to carry out multiple and sometimes opposite functions. We show here that translational reprogramming occurs during macrophage this relies on the Elongator complex subunit Elp3, an enzyme modifies wobble uridine base U34 in cytosolic tRNAs. Elp3 expression downregulated by classical M1‐activating signals myeloid cells, where it limits production of pro‐inflammatory cytokines via...
Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered several human cancers. In mouse model, DUSP3 deletion prevents neo-angiogenesis b-FGF-induced microvessel outgrowth. Considering the importance of angiogenesis metastasis formation, our study aimed to investigate tumour dissemination. Using a Lewis Lung carcinoma (LLC) experimental we observed that DUSP3-/- mice developed larger lung metastases than...
Abstract Dual-specificity phosphatase 3 (DUSP3) is a small with poorly known physiological functions and for which only few substrates are known. Using knockout mice, we recently reported that DUSP3 deficiency confers resistance to endotoxin- polymicrobial-induced septic shock. We showed this protection was macrophage dependent. In study, further investigated the role of in sepsis tolerance sex adoptive-transfer experiments ovariectomized highlighted female hormones phenotype. Indeed,...
Abstract Helminth infection conditions lung macrophages in the long term, but little is known about how helminths affect macrophage responses to respiratory viral coinfection. Experimental helminth of BALB/c and C57BL/6 mice revealed an increased type 2 airway inflammation that was associated with pronounced phenotypic changes macrophages. These consist a disappearance reaction SiglecF+ alveolar (AlvMs) concomitant recruitment monocyte-derived Monocyte-derived replenish airways lung, as...