A5019553994- Retinal Imaging and Analysis
- Genetics and Neurodevelopmental Disorders
- Retinal Diseases and Treatments
- Autism Spectrum Disorder Research
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Glaucoma and retinal disorders
- Psychological and Temporal Perspectives Research
- Neurobiology and Insect Physiology Research
- Child Development and Digital Technology
- Bipolar Disorder and Treatment
- Genetic Syndromes and Imprinting
- MicroRNA in disease regulation
- Dietary Effects on Health
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Receptor Mechanisms and Signaling
- Congenital heart defects research
- Genetic Associations and Epidemiology
Ludwig-Maximilians-Universität München
2019-2025
LMU Klinikum
2022-2024
Max Planck Institute of Psychiatry
2019
Schizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as whether these alterations reflect a disease-specific process or rather consequence of comorbid diseases concomitant microvascular impairment.The study included 126 eyes 65 patients SSDs and 143 72 healthy controls. We examined macula optic disc measures by optical coherence tomography (OCT) OCT angiography (OCT-A). Additive mixed models were used assess the impact on...
Importance As an accessible part of the central nervous system, retina provides a unique window to study pathophysiological mechanisms brain disorders in humans. Imaging and electrophysiological studies have revealed retinal alterations across several neuropsychiatric neurological disorders, but it remains largely unclear which specific cell types biological are involved. Objective To determine whether affected by genomic risk for explore through converges these types. Design, Setting,...
Abstract Many psychiatric disorders, for example, anxiety, are accompanied by disturbances of circadian rhythms, including disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine function. Conversely, alternations rhythms a risk factor the development disorders. This assumption is supported animals with clock gene mutations which often display behaviors that resemble human In this study, we performed an in‐depth behavioral analysis male mice lacking central genes...
Recently, hundreds of risk genes associated with psychiatric disorders have been identified. These are thought to interact environmental stress factors in precipitating pathological behaviors. However, the individual phenotypes resulting from specific genotype by environment (G×E) interactions remain be determined. Toward a more systematic approach, we developed novel standardized and partially automatized platform for behavioral cognitive profiling (PsyCoP). Here, assessed disturbances Tcf4...
Oligodendrocytes (OLs) are critical for myelination and implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression different combinations the transcription factors SOX10 (S), OLIG2 (O), NKX6.2 (N). Here, we applied quantitative image analysis single-cell transcriptomics to compare factor (TF) their efficacy towards robust OL lineage conversion. Compared with S alone, combination SON increases...
Cognitive deficits are a hallmark of schizophrenia, for which no convincing pharmacological treatment option is currently available. Here, we tested spironolactone as repurposed compound in Tcf4 transgenic mice subjected to psychosocial stress. In this '2-hit' gene by environment mouse (GxE) model, the animals showed schizophrenia-related cognitive deficits. We had previously shown that ameliorates working memory and hyperactivity model cortical excitatory/inhibitory (E/I) dysbalance caused...
Alcohol use disorder (AUD) is a widespread addiction with severe consequences for health. AUD patients often suffer from sleep disturbances and irregular daily patterns. Conversely, disruptions of circadian rhythms are considered risk factor alcohol relapses. In this study, we investigated the extent to which genetic environmental their interaction alter drinking behaviour in mice. As model disruption, used Cryptochrome1/2-deficient (Cry1/2-/- ) mice strongly suppressed found that they...
Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets significantly associated with response. Among the top hits was
Importance: As an accessible part of the central nervous system, retina provides a unique window to study pathophysiological mechanisms brain disorders in humans. Imaging and electrophysiological studies have revealed retinal alterations across several neuropsychiatric neurological disorders. However, it remains largely unclear whether primary disease within contribute observed which specific cell types biological are involved. Objective: To determine affected by genomic risk for explore...