A5103123107- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Medical and Health Sciences Research
- Intraocular Surgery and Lenses
- Criminal Law and Policy
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Law and Political Science
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- COVID-19 diagnosis using AI
- Artificial Intelligence in Healthcare and Education
- Hemodynamic Monitoring and Therapy
- Pancreatitis Pathology and Treatment
- Retinal and Macular Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- German Literature and Culture Studies
- Ocular Diseases and Behçet’s Syndrome
- Atherosclerosis and Cardiovascular Diseases
- Diverse Legal and Medical Studies
- Patient Satisfaction in Healthcare
- Neuroendocrine Tumor Research Advances
Ludwig-Maximilians-Universität München
2014-2024
LMU Klinikum
2017-2023
Ortenau Klinikum
2021
Moorfields Eye Hospital NHS Foundation Trust
2019-2020
University College London
2019-2020
Moorfields Eye Hospital
2019-2020
National Health Service
2019-2020
Augenklinik Heidelberg
2016-2020
München Klinik
2020
Heidelberg University
2019
BackgroundDeep learning has the potential to transform health care; however, substantial expertise is required train such models. We sought evaluate utility of automated deep software develop medical image diagnostic classifiers by health-care professionals with no coding—and learning—expertise.MethodsWe used five publicly available open-source datasets: retinal fundus images (MESSIDOR); optical coherence tomography (OCT) (Guangzhou Medical University and Shiley Eye Institute, version 3);...
We assessed differences in compliance and adherence (lateness of patients, visual acuity, reasons for abstaining) between patients with diabetic macular edema (DME) age-related degeneration (AMD), both under anti-vascular endothelial growth factor therapy.We included 136 DME (36% women, 65 years, 22 visits, 13.9 injections, 29.9 months follow-up) 109 AMD (59% 76 20 14.7 22.3 (minimum follow-up 12 at least 5 injections). missed appointments >14 days) therapy break-offs >100 days). All delayed...
Background Hospital Eye Services (HES) in the UK face an increasing number of optometric referrals driven by progress retinal imaging. The National Health Service (NHS) published a 10-year strategy (NHS Long-Term Plan) to transform services meet this challenge. In study, we implemented cloud-based referral platform improve communication between optometrists and ophthalmologists. Methods Retrospective cohort study conducted at Moorfields Hospital, Croydon Foundation Trust, London, UK)....
Purpose To compare the efficacy of a computer-assisted marker system for toric intraocular lenses (IOLs) (Callisto Eye System) with manual marking techniques. Setting University Hospital Munich, Ludwig-Maximilians-University, Germany. Design Prospective case series. Methods This study included patients having cataract surgery implantation IOL (Torbi 709 M). They were randomly assigned to 1 2 groups based on used, or digital. Patients if they had age-related and regular corneal astigmatism...
Schizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as whether these alterations reflect a disease-specific process or rather consequence of comorbid diseases concomitant microvascular impairment.The study included 126 eyes 65 patients SSDs and 143 72 healthy controls. We examined macula optic disc measures by optical coherence tomography (OCT) OCT angiography (OCT-A). Additive mixed models were used assess the impact on...
CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role pancreatic cancer (PC) has not yet been investigated.Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measurements of 21-1, carbohydrate antigen 19-9 (CA 19-9) carcinoembryonic (assessed by Elecsys 2010, Roche Diagnostics) during palliative first-line chemotherapy obtained. Biomarker data correlated...
Abstract Purpose To determine the anatomical and functional outcomes of an extended 6-month intravitreal anti-vascular endothelial growth factor (anti-VEGF) upload in choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR). Methods A retrospective database analysis was performed applying following inclusion criteria: (1) diagnosis CSCR, (2) CNV, (3) treatment at least six consecutive injections anti-VEGF. Outcome measures included change retinal...
<h3>Importance</h3> Although multiple imputation models for missing data and the use of mixed-effects generally provide better outcome estimates than using only observed or last observation carried forward in clinical trials, such approaches usually cannot be applied to visual outcomes from retrospective analyses practice settings, also called real-world outcomes. <h3>Objective</h3> To explore potential usefulness survival analysis techniques <h3>Design, Setting, Participants</h3> This...
Abstract Objectives To determine real-life quantitative changes in OCT biomarkers a large set of treatment naive patients setting undergoing anti-VEGF therapy. For this purpose, we devised novel deep learning based semantic segmentation algorithm providing the first benchmark results for automatic 11 features including neovascular age-related macular degeneration (nAMD). Methods Training Deep U-net ensemble state-of-the-art performance which was used to analyze prior to, after 3 and 12...
Introduction Treatment of severe mental illness (SMI) symptoms, especially negative symptoms and cognitive dysfunction in schizophrenia, remains a major unmet need. There is good evidence that SMIs have strong genetic background are characterized by multiple biological alterations, including disturbed brain circuits connectivity, dysregulated neuronal excitation-inhibition, dopaminergic glutamatergic pathways, partially inflammatory processes. The ways which the signaling pathways...
Purpose . To compare two calculators for toric intraocular lens (IOL) calculation and to evaluate the prediction of refractive outcome. Methods Sixty-four eyes forty-five patients underwent cataract surgery followed by implantation a (Zeiss Torbi 709 M) calculated standard industry calculator using front keratometry values. Prediction error, median absolute astigmatism error were evaluated calculator. The predicted postoperative refraction power values compared after recalculation Barrett...
Background: Deep learning offers considerable promise for medical diagnostics. In this review, we evaluated the diagnostic accuracy of deep (DL) algorithms versus health care professionals (HCPs) in classifying diseases from imaging. Methods: We searched (Pre-)Medline, Embase, Science Citation Index, Conference Proceedings and arXiv 01 January 2012 until 31 May 2018. Studies comparing performance DL models HCPs, any pre-specified condition based on imaging material, were included. extracted...
The purpose of this study was to identify differences in clinical corneal findings after standard and accelerated epithelial off cross-linking (CXL) during a long-term follow-up.Two hundred forty-one patients (184 male) were included monocentric, retrospective, non-randomized unmasked study. One forty-eight eyes treated with the protocol 138 CXL, if diagnosed keratoconus progression Kmax more than one dioptre preceding 6 months, plus minimal pachymetry measurement 400 μm keratometry...
The present prospective single-center study investigated the prognostic role of novel serum biomarkers in advanced pancreatic cancer (PC). Patients (pts) with locally or metastatic PC treated first-line palliative chemotherapy were included. Among others, markers CYFRA 21-1, haptoglobin, serum-amyloid A (SAA), and 25-OH vitamin D3 determined at baseline categorized by pre-defined cut-offs [median values (MV), upper limits normal (ULN), lower (LLN), natural logarithm (ln)] correlated overall...
Diabetes prevalence is constantly rising, involving the eyes with damage including development of diabetic macular oedema. Since 2012, intravitreal anti-vascular endothelial growth factor medication available for oedema treatment. Endocrinological studies have shown that fewer women are affected by diabetes. However, when affected, they exhibit more severe complications than men. We investigated gender-related differences in and outcome an ophthalmological tertiary referral hospital.We...
To evaluate the effectiveness of 0.19-mg fluocinolone acetonide implant (FAi) for preventing inflammatory relapses in noninfectious uveitis with posterior segment involvement standard clinical practice. Further, to assess value remission induction therapy intraocular and periorbital administered high-dose corticosteroids before FAi.A retrospective cohort study a tertiary referral center specialized management. The primary outcomes were best-corrected visual acuity (BVCA) central retinal...
ABSTRACTPurpose To evaluate the long-term outcomes of patients with non-infectious uveitis treated 0.19 mg fluocinolone acetonide insert (FAi) for up to 36 months in clinical practice.Methods A retrospective study conducted at a single center.Results Fifty eyes 39 were included. Mean best corrected visual acuity (BCVA) and central retinal thickness (CRT) remained stable until month after FAi implantation (61.04 vs. 70.25 letters 370.8 332.5 µm, respectively). The recurrence rate was 34% (17...