A5061024466- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Retinal Imaging and Analysis
- Genetic Associations and Epidemiology
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Folate and B Vitamins Research
- Birth, Development, and Health
- Single-cell and spatial transcriptomics
- Pharmacological Effects and Toxicity Studies
- Retinal Diseases and Treatments
- Bioinformatics and Genomic Networks
- Glaucoma and retinal disorders
- Mental Health Treatment and Access
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- MRI in cancer diagnosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
Ludwig-Maximilians-Universität München
2016-2025
Max Planck Institute of Psychiatry
2015-2025
LMU Klinikum
2018-2024
Wakayama Medical University
2023
Medizinische Hochschule Hannover
2023
Baum Consult
2019
Max Planck Society
2013
Epidemiological and clinical studies have shown that children exposed to adverse experiences are at increased risk for the development of depression, anxiety disorders, posttraumatic stress disorder (PTSD). A history child abuse maltreatment increases likelihood being subsequently traumatic events or developing PTSD as an adult. The brain is highly plastic during early life encodes acquired information into lasting memories normally subserve adaptation. Translational in rodents showed...
Schizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as whether these alterations reflect a disease-specific process or rather consequence of comorbid diseases concomitant microvascular impairment.The study included 126 eyes 65 patients SSDs and 143 72 healthy controls. We examined macula optic disc measures by optical coherence tomography (OCT) OCT angiography (OCT-A). Additive mixed models were used assess the impact on...
Abstract Background and Hypothesis Cognitive impairment is a hallmark of schizophrenia, but no effective treatment available to date. The underlying pathophysiology includes disconnectivity between hippocampal prefrontal brain regions. Supporting evidence comes from diffusion-weighted imaging studies that suggest abnormal organization frontotemporal white matter pathways in schizophrenia. Study Design Here, we hypothesize deficient maturation oligodendrocyte precursor cells (OPCs) into...
Importance As an accessible part of the central nervous system, retina provides a unique window to study pathophysiological mechanisms brain disorders in humans. Imaging and electrophysiological studies have revealed retinal alterations across several neuropsychiatric neurological disorders, but it remains largely unclear which specific cell types biological are involved. Objective To determine whether affected by genomic risk for explore through converges these types. Design, Setting,...
Schizophrenia (SCZ) is a highly heritable brain disorder marked by wide range of changes throughout the central nervous system. These include alterations at molecular and cellular levels, suggesting significant disruptions in synapse function, as well modifications structure activity. However, it remains unclear, how biology translate into neurophysiological ultimately behavioral consequences across scales. Here, we narrow this translational gap contemporary biological psychiatry...
According to the excitation-inhibition imbalance theory, GABAergic and glutamatergic systems influence clinical symptoms particularly cognitive deficits in schizophrenia spectrum disorders (SSD). These have been found disrupted anterior cingulate cortex (ACC) dorsolateral prefrontal (DLPFC) SSD, are associated with P300 abnormalities electroencephalography recordings. Therefore, we explored relationships among MRS-derived GABA Glx levels ACC left DLPFC (lDLPFC), auditory amplitudes...
Background: Schizophrenia spectrum disorders (SSD) present substantial clinical and biological heterogeneity, impeding advances in diagnostic precision personalised treatment. Despite consistent evidence of brain alterations, interindividual variability the predominance single-modality neuroimaging analyses hinder identification subgroups reflecting disorders' complexity. We developed a novel meta-analytically anchored clustering approach integrating structural (T1-weighted, diffusion tensor...
Hippocampus-related cognitive deficits in working and verbal memory are frequent schizophrenia, hippocampal volume loss, particularly the cornu ammonis (CA) subregions, was shown by magnetic resonance imaging studies. However, underlying cellular alterations remain elusive. By using unbiased design-based stereology, we reported a reduction oligodendrocyte number CA4 schizophrenia of granular neurons dentate gyrus (DG). Here, aimed to replicate these findings an independent sample. We used...
Vitamin deficiency syndromes and blood-brain barrier (BBB) dysfunction are frequent phenomena in psychiatric conditions. We analysed the largest available first-episode schizophrenia-spectrum psychosis (FEP) cohort to date regarding routine cerebrospinal fluid (CSF) blood parameters investigate association between vitamin deficiencies (vitamin B12 folate) BBB impairments FEP. report a retrospective analysis of clinical data from all inpatients that were admitted our tertiary care hospital...
Introduction Treatment of severe mental illness (SMI) symptoms, especially negative symptoms and cognitive dysfunction in schizophrenia, remains a major unmet need. There is good evidence that SMIs have strong genetic background are characterized by multiple biological alterations, including disturbed brain circuits connectivity, dysregulated neuronal excitation-inhibition, dopaminergic glutamatergic pathways, partially inflammatory processes. The ways which the signaling pathways...
Abstract Hippocampal volume decrease is a structural hallmark of schizophrenia (SCZ), and convergent evidence from postmortem imaging studies suggests that it may be explained by changes in the cytoarchitecture cornu ammonis 4 (CA4) dentate gyrus (DG) subfields. Increasing indicates aerobic exercise increases hippocampal CA subfields improves cognition SCZ patients. Previous showed effects on hippocampus might connected to polygenic burden risk variants. However, little known about cell...
Background and Objectives Numbers of drug‐related deaths have been growing in Europe the USA, especially those attributable to mixed drug consumption. Overdose account for about one third up half all illicit worldwide. In most cases opioids are involved. Opioid maintenance treatment (OMT) is a well‐established therapy option among people with opioid dependence. The aim this study was assess concomitant substance abuse opioid‐dependent patients under OMT two centers Munich, Germany. Methods...
Significant evidence links white matter (WM) microstructural abnormalities to cognitive impairment in schizophrenia (SZ), but the relationship of these with functional outcome remains unclear.
Translational research on complex, multifactorial mental health disorders, such as bipolar disorder, major depressive schizophrenia, and substance use disorders requires databases with large-scale, harmonized, integrated real-world data. The Munich Mental Health Biobank (MMHB) is a health-specific biobank that was established in 2019 to collect, store, connect, supply high-quality phenotypic data biosamples from patients study participants, including healthy controls, recruited at the...
Background Psychiatry is facing major challenges during the current coronavirus disease 2019 (COVID)-19 pandemic. These involve its actual and perceived role within medical system, in particular how psychiatric hospitals can maintain their core mission of attending to people with mental illness while at same time providing relief overstretched general medicine services. Although disorders comprise leading cause global burden disease, healthcare has been deemphasised wake onslaught pandemic:...
Oligodendrocytes (OLs) are critical for myelination and implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression different combinations the transcription factors SOX10 (S), OLIG2 (O), NKX6.2 (N). Here, we applied quantitative image analysis single-cell transcriptomics to compare factor (TF) their efficacy towards robust OL lineage conversion. Compared with S alone, combination SON increases...