A5055048278- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Pregnancy and Medication Impact
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune and Inflammatory Disorders
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders Research
- Pharmaceutical studies and practices
- Complementary and Alternative Medicine Studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- Endometriosis Research and Treatment
- Vitamin D Research Studies
- Biosimilars and Bioanalytical Methods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone health and osteoporosis research
- Retinoids in leukemia and cellular processes
- Hidradenitis Suppurativa and Treatments
- Reproductive System and Pregnancy
- Vitamin C and Antioxidants Research
- Rheumatoid Arthritis Research and Therapies
- Urticaria and Related Conditions
University College Dublin
1982-2024
Baylor University Medical Center
2010-2020
St. Vincent's University Hospital
2008-2019
Stone Clinic
2019
Sanofi (Mexico)
2018
Novartis (Switzerland)
2018
Regeneron (United States)
2018
Texas A&M Health Science Center
2014-2016
Baylor University
2010-2014
Veterinary Medical Center
2013
Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying dramatically altered mRNA expression profiles.However, much less known about the of small RNAs.Here, we describe comprehensive analysis normal psoriatic miRNAome next-generation sequencing in large patient cohort.We generated 6.7 3 10 8 RNA reads representing 717 284 putative novel microRNAs (miRNAs).We also observed widespread isomiRs miRNA * s derived from loci, low frequency editing skin.The processing...
Psoriasis severity categories have been important tools for clinicians to use in treatment decisions as well determine eligibility criteria clinical studies. However, owing the heterogeneity of classifications and their lack consideration impact psoriasis involvement special areas or past history, patients may be miscategorized, which can lead undertreatment psoriasis.To develop a consensus statement on classification severity.A modified Delphi approach was developed by International Council...
Genital psoriasis (GenPs) is a common, debilitating and difficult-to-treat manifestation of plaque psoriasis. However, few controlled, interventional studies GenPs exist.To determine the efficacy ixekizumab vs. placebo in patients with moderate-to-severe ≥ 1% involved body surface area (BSA).Patients GenPs, defined as baseline static Physician's Global Assessment Genitalia (sPGA-G) score 3, BSA were randomized 1 : to receive (n = 74) or recommended dosing 75). Major outcomes included...
Engaging global key opinion leaders, the International Psoriasis Council (IPC) held a day-long roundtable discussion with primary purpose to discuss treatment goals of psoriasis patients and worldwide barriers optimal care. Setting clear expectations might ultimately encourage undertreated seek care in an era which great gains therapeutic efficacy have been achieved. Here, we option for early all categories alleviate disease impact while emphasizing need more focused attention mild moderate...
Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients psoriasis has not been compared other conditions and more rigorous disease screening, such as type 2 diabetes.To assess the burden asymptomatic coronary measured by artery calcium score moderate to severe diabetes healthy controls.Three single-center, cross-sectional studies were performed recruited from specialty outpatient clinics without (recruited November 1, 2013, through...
Abstract The intermittent use of dilute sodium hypochlorite “bleach baths” has shown efficacy as adjunctive therapy for atopic dermatitis ( AD ). This feasibility study evaluated the clinical response and patient acceptability treatment with a cleansing body wash containing in children . was 12‐week open‐label 18 conducted pediatric dermatology outpatient clinic between May 2011 July 2012. Children moderate to severe , defined an Investigator Global Assessment IGA ) score at least 3 on...
Plaque psoriasis is a chronic skin disease where genital involvement relatively common. Yet health care providers do not routinely evaluate patients for and readily initiate discussion of it.A qualitative study 20 US with dermatologist-confirmed (GenPs) self-reported moderate-to-severe GenPs at screening was conducted to identify key symptoms their impacts on health-related quality life (HRQoL).Patients had mean age 45 years, 55% were female, high rates current/recent overall (65%) (70%)...
Objectives: To determine whether narrowband UV-B (NB-UV-B) may mediate its beneficial effect on psoriasis by increasingvitaminDlevels,andtoassesstheeffectofNB-UV-B vitamin D status in patients with wintertime.
Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Recent findings have furthered our understanding the complex pathophysiology PsA. There been major advances in identification genes associated with joint involvement but not cutaneous disease alone. The elucidation key immunologic pathways has allowed development novel targeted therapies that are research pipeline. Currently, good screening tests and biomarkers to diagnose early...
Abstract Introduction Genital psoriasis (GenPs) is common and distressing for patients, but often not discussed with physicians, no previous clinical trials have assessed the effects of biologics specifically on GenPs its associated symptoms. Aim To report results novel patient-reported outcomes (PROs) assessment symptoms sexual impact before after treatment in IXORA-Q study. Methods (NCT02718898) was a phase III, randomized, double-blind, placebo-controlled study ixekizumab (80 mg/2 weeks...