A5021984801- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Body Composition Measurement Techniques
- Reproductive System and Pregnancy
- Iron Metabolism and Disorders
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Central Venous Catheters and Hemodialysis
- Erythropoietin and Anemia Treatment
- Pharmacological Effects and Toxicity Studies
- Hemoglobinopathies and Related Disorders
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Health Systems, Economic Evaluations, Quality of Life
- Palliative and Oncologic Care
- Metabolism and Genetic Disorders
- Complement system in diseases
- Drug-Induced Hepatotoxicity and Protection
Centre for Health Technology and Services Research
2009-2024
Universidade do Porto
2007-2024
Fundação Oswaldo Cruz
2024
Hospital de São João
2004-2021
Chalmers University of Technology
2021
University of Sheffield
2021
Centro Hospitalar do Porto
2013-2016
Hospital de Santo António
2013
Universidade Federal de Minas Gerais
2013
Fundação para a Ciência e Tecnologia
2009
A Th1 response is said to be associated with transplant rejection and Th2 tolerance, although this not agreed by all. Cytokines evaluation in peripheral blood urine kidney transplants produces variable results. We hypothesized that measurement of major cytokines involved Th1/Th2 paradigm on renal-infiltrating cells could bring valuable scientific clinical information.Fifty-six adult cadaver were subdivided into 21 stable patients (group A), 22 suffering acute B), 10 chronic C) three CMV...
Optimizing reproducibility evaluation for RAPD markers those bands that were reproduced in these individuals.We compared genetic parameter estimates using HICKORY and POPGENE softwares on an unreduced data set sets which we eliminated based repeatability of individuals selected by simulated annealing three randomly individuals.Genetic very similar when used the optimization procedure to reduce number analyzed, but as expected, selecting only evaluate produced different estimates.We conclude...
Purpose The aim of this work is to evaluate the patient-reported health-related quality life (HRQOL), according type and location vascular access used for dialysis procedure. Methods In transversal study, 322 end-stage renal disease (ESRD) patients under online hemodiafiltration (OL-HDF, 59.63% males; 64.9±14.3 years) were enrolled. Arteriovenous fistula (AVF) was by 252 (78.3%), whereas 70 (21.7%) had a central venous catheter (CVC). Besides AVF location, data on comorbidities,...
C. Carvalho, I. Ferreira, S. Gaião, Guimarães, R. Costa, J. Santos, Sampaio, M. Bustorff, G. Oliveira, Pestana. Cerebral coccidioidomycosis after renal transplantation in a non-endemic area.Transpl Infect Dis 2010: 12: 151–154. All rights reserved Abstract: Coccidioidomycosis is fungal infection caused by Coccidioides species endemic to the desert south western United States. In healthy people, manifestations range mainly from asymptomatic mild influenza-like syndrome. immunosuppressed...
The authors present a case of urinary infection by non-tuberculous mycobacteria (NTM) species, Mycobacterium gordonae, in renal transplant recipient. A 29-year-old female patient had persistent sterile pyuria after her second kidney transplant. An NTM, M. was isolated, and the started on antituberculous treatment, with resolution leukocyturia. Ureteral stenosis hydronephrosis deterioration allograft function diagnosed later and, despite introduction intraureteral catheter hydronephrosis,...
DNA damage and inflammation are common in end-stage renal disease (ESRD). Our aim was to evaluate the levels of circulating cell-free (cfDNA) relationship with inflammation, anaemia, oxidative stress haemostatic disturbances ESRD patients on dialysis. By performing a 1-year follow-up study, we also aimed predictive value cfDNA for outcome patients. A total 289 dialysis were enrolled study: evaluated cfDNA, haemogram, serum iron, hepcidin, inflammatory markers, haemostasis. Events causes...
Background. The new immunosuppressive drug Rapamycin (Rapa) is endowed with a mechanism of action that distinct from calcineurin inhibitors. It has been claimed Rapa does not significantly modulate either the cytokine expression or transcription several growth factors in mitogen-activated T cells. Previously, we reported fine-needle aspiration biopsy (FNAB) sample cultures synthesize large array cytokines, and some them may be powerful predictors acute rejection renal transplants. We...
Background: Soluble transferrin receptor (sTfR) is a biomarker of erythropoiesis, which often impaired in dialysis patients. The aim our study was to evaluate sTfR levels chronically dialyzed patients and assess potential determinants its levels.Methods: We performed cross-sectional by evaluating 246 end-stage renal disease undergoing 32 healthy controls. Circulating interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, hepcidin, sTfR, growth differentiation 15...
Monocytes-macrophages are found within kidney allografts during the first days after surgery, where they perform "housekeeping" tasks, participate in postreperfusion injury, and act as antigen-presenting cells, well become involved effector phase of acute rejection. They also seem to play a prominent role chronic We quantified their presence fine-needle aspiration biopsies studied growth factors that, we hypothesized, would mark different implications monocytes-macrophages.Fine-needle were...
This work aimed to evaluate how aging could influence patients' perception of health quality life (HRQOL), as well as, the effect on dialysis adequacy and in hematological, iron status, inflammatory nutritional markers. In this transversal study were enrolled 305 ESRD patients under online-hemodiafiltration (OL-HDF) (59.67% males; 64.9 ± 14.3 years old). Data about comorbidities, hematological data, adequacy, markers collected from patient's records. Moreover, HRQOL score, by using Kidney...
Background. Peripheral blood lymphocyte (PBL) analysis by flow cytometry has been inconsistently reported as an adjunctive method for diagnosing acute kidney transplant rejection. However, there is good evidence that lymphocytes infiltrating renal grafts differ from those found at the peripheral level. We hypothesized study of aspiration biopsy samples in conjunction with PBL would enable us to diagnose rejection crisis reliably. Methods. Lymphocytes and biopsies patients were analyzed....
Carvalho C, Coentrão L, Bustorff M, Patrício E, Sampaio S, Santos J, Oliveira G, Pestana M. Conversion from sirolimus to everolimus in kidney transplant recipients receiving a calcineurin‐free regimen. Clin Transplant 2011: 25: E401–E405. © 2011 John Wiley & Sons A/S. Abstract: Background: Everolimus (EVL) and (SRL) were introduced into immunosuppressive regimens, an attempt replace or reduce the dose of nephrotoxic calcineurin inhibitors (CNI). In our institution, due administrative...
<i>Background:</i> T-cell activation, the key event in development of acute allograft rejection, depends on co-stimulatory signals delivered by antigen-presenting cells (APC). APC-derived cytokines may provide co-stimulation and modulate alloimmune reaction. We have studied cytokine synthesis fine-needle aspiration biopsy (FNAB) culture we found significant differences for interleukin (IL)-2, IL-6, IL-10, M-CSF IL-1ra comparing rejection versus stable kidney transplant patients....
The urinary excretion of free dopamine has been used as an index the renal synthesis amine. However, it is now well recognized that in kidney, newly-formed significantly inactivated through deamination to 3,4-dihydroxyphenylacetic acid (DOPAC) by monoamine oxidase (MAO). aim present study was assess dopaminergic system activity during recovery function kidney transplant recipients and which parameters are appropriate for evaluation amine under these conditions.Twenty-four-hour L-DOPA, its...
Previously, we have reported that flow cytometry analysis of fine-needle aspirates can accurately predict rejection in kidney transplants treated with cyclosporine-azathioprine-prednisolone. In this study, examined technique's accuracy using current immunosuppression.Kidney transplant recipients were calcineurin inhibitors, mycophenolate mofetil, and prednisolone: 92 remained rejection-free - Group I 37 developed acute II. An allograft aspiration specimen peripheral blood collected from on...