A5067111825- Erythrocyte Function and Pathophysiology
- Erythropoietin and Anemia Treatment
- Hemoglobinopathies and Related Disorders
- Dialysis and Renal Disease Management
- Blood properties and coagulation
- Iron Metabolism and Disorders
- Biomarkers in Disease Mechanisms
- Pregnancy and preeclampsia studies
- Neonatal Health and Biochemistry
- Psoriasis: Treatment and Pathogenesis
- Heme Oxygenase-1 and Carbon Monoxide
- Dermatology and Skin Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Connexins and lens biology
- Antioxidant Activity and Oxidative Stress
- Central Venous Catheters and Hemodialysis
- Lipoproteins and Cardiovascular Health
- GDF15 and Related Biomarkers
- Redox biology and oxidative stress
- Reproductive System and Pregnancy
- Lanthanide and Transition Metal Complexes
- Edible Oils Quality and Analysis
- Hemoglobin structure and function
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
Universidade do Porto
2015-2025
Rede de Química e Tecnologia
2008-2023
Forest Research
2019
Centre de Biologie et de Gestion des Populations
2017
University of Évora
2015-2016
Instituto de Biologia Molecular e Celular
2006-2015
Centro De Medicina Veterinária Anjos De Assis
2013-2014
Hospital de Dona Estefânia
2013
Instituto de Biología Molecular y Celular de Rosario
2008-2009
Hospital de São João
2008-2009
Several cross-sectional studies have shown that different cytokines and growth factors are enhanced in psoriasis.We aimed to understand the role/relation of interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial factor (VEGF) tumour necrosis (TNF)-α psoriasis vulgaris, addressing their levels changes before, during after psoralen-ultraviolet A (PUVA) narrowband ultraviolet B (NB-UVB) treatment.A a longitudinal study (n = 34) - before (T0) at 3 (T3), 6 (T6) 12 (T12) weeks NB-UVB PUVA...
Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool medical diagnosis and treatment monitoring across multiple clinical settings. Studies shown that exposure GBCAs is associated with gadolinium release tissue deposition may cause short- long-term toxicity in several organs, including the kidney, main excretion organ of most GBCAs. Considering increasing prevalence chronic kidney disease worldwide complications...
Psoriasis vulgaris is a chronic recurrent inflammatory skin disease and psoriatic lesions have shown leucocyte infiltration.We aimed to study C-reactive protein (CRP) activation markers/inhibitors as potential monitors of psoriasis vulgaris.A cross-sectional (n = 73) longitudinal (before, at 3, 6 12 weeks therapy; n 47) was performed; 10 patients started topical treatment, 17 narrow-band ultraviolet light B (NBUVB) 20 psolaren associated UVA (PUVA); severity defined by Area Severity Index...
Abstract Background Psoriasis vulgaris is associated with overweight/obesity and increased C‐reactive protein (CRP), tumour necrosis factor (TNF)‐α, interleukin (IL)‐6, leptin resistin levels decreased adiponectin levels. Objectives To understand the role/relationship of adipokines, as well CRP, in a Portuguese psoriatic population, by assessing relationship their psoriasis severity, defined Area Severity Index (PASI), obesity, body mass index (BMI), therapy. Methods A cross‐sectional ( n =...
Many studies have investigated the protective effects of oleuropein and hydroxytyrosol against cell injury, but few aglycones 3,4-dihydroxyphenylethanol-elenolic acid (3,4-DHPEA-EA) dialdehyde (3,4-DHPEA-EDA). The present work studied compared capacity these four compounds, found at high concentrations in olive oil, to protect red blood cells (RBCs) from oxidative injury. vitro stress RBCs was induced by water-soluble radical initiator 2,2'-azo-bis(2-amidinopropane) dihydrochloride. RBC...
Preeclampsia (PE) is one of the main causes maternal and fetal mortality morbidity. PE associated with an inflammatory state oxidative stress, in circulation. Our aim was to evaluate compare levels stress markers umbilical cord blood (UCB), normal pregnancies. We measured acute-phase proteins (CRP α1-antitrypsin), proinflammatory cytokines (IL-6 TNF-α), leukocyte activation (elastase, lactoferrin, sL-selectin, sVCAM, sPECAM), total antioxidant status (TAS), thiobarbituric acid reactive...
Erythrocytes are continuously exposed to risk of oxidative injury due oxidant oxygen species. To prevent damage, they have antioxidant agents namely, catalase (Cat), glutathione peroxidase (GPx), and peroxiredoxin 2 (Prx2). Our aim was contribute a better understanding the interplay between Prx2, Cat, GPx under H2O2-induced stress, by studying their changes in red blood cell cytosol membrane, different conditions. These three enzymes were quantified immunoblotting. Malondialdehyde, that is,...
The present work studied and compared the capacity of four important olive oil polyphenolic compounds, oleuropein, hydroxytyrosol, oleuropein aglycones 3,4-dihydroxyphenylethanol-elenolic acid (3,4-DHPEA-EA) dialdehyde (3,4-DHPEA-EDA), to protect red blood cells (RBCs) from oxidative hemolysis induced by physiological initiator H2O2. amount was evaluated spectrophotometrically. compounds were also tested in presence absence naturally occurring antioxidant ascorbic acid. All revealed...
A identificação de um bebê prematuro pode se mostrar pelo acompanhamento pré-natal durante a gravidez processo exames rotina ao longo desse período. É fundamental os esse período gestação até pela saúde da mãe, e o sua gravidez, no entanto algumas dessas gestações apresentam alguns risco complicações, dentre elas prematuridade, que torna uma das principais causas mortalidade infantil. Identificar na literatura as terapias utilizadas tratamento prematuros para melhorar qualidade respiratória...
Regarding the safety of gadolinium (Gd (III))-based contrast agents, we aimed to evaluate short- and long-term effects following a single exposure gadoteric acid (DOTA) or free Gd (III) using animal models. Biomarkers kidney injury, inflammation, iron metabolism, dyslipidemia, hepatic hematologic disturbances histopathological differential gene expression (DGE) analyses were evaluated. In short-term study, compared controls, was associated with higher inflammation; changes in lipid,...
Recent studies of chitosan have increased the interest in its conversion to chitooligosaccharides (COSs) because these compounds are water-soluble and potential use several biomedical applications. Furthermore, such oligomers may be more advantageous than chitosans their much higher absorption profiles at intestinal level, which permit facilitated access systemic circulation distribution throughout entire human body. In that perspective, it is important clarify effect on blood further,...
The antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and peroxiredoxin 2 (Prx2) are particularly important in erythroid cells. Reticulocytes other precursors may adapt their biosynthetic mechanisms to cell defects or changes the bone marrow environment. Our aim was perform a comparative study of mRNA levels CAT, GPX1, PRDX2 SOD1 reticulocytes from healthy individuals patients with hereditary spherocytosis (HS), sickle disease (SCD) β-thalassemia...
This title was also presented orally at Clinical Biochemistry workshop,Faro, 29 Janeiro, 2010