A5080991210- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Health and Lifestyle Studies
- Children's Physical and Motor Development
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Erythrocyte Function and Pathophysiology
- Nanocomposite Films for Food Packaging
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Apelin-related biomedical research
- Body Composition Measurement Techniques
- Blood properties and coagulation
- Erythropoietin and Anemia Treatment
- Diet and metabolism studies
- Migraine and Headache Studies
- Regulation of Appetite and Obesity
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Sympathectomy and Hyperhidrosis Treatments
- Studies on Chitinases and Chitosanases
- Multiple Sclerosis Research Studies
- Birth, Development, and Health
- Pharmacological Effects and Toxicity Studies
Hospital de Santo António
2022-2024
Centro Hospitalar do Porto
2021
Universidade do Porto
2010-2020
Rede de Química e Tecnologia
2008-2020
CUF Porto Hospital
2020
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2016
Instituto de Biologia Molecular e Celular
2011-2015
Louisiana State University System
2015
University of Coimbra
2015
Pennington Biomedical Research Center
2015
Many studies have investigated the protective effects of oleuropein and hydroxytyrosol against cell injury, but few aglycones 3,4-dihydroxyphenylethanol-elenolic acid (3,4-DHPEA-EA) dialdehyde (3,4-DHPEA-EDA). The present work studied compared capacity these four compounds, found at high concentrations in olive oil, to protect red blood cells (RBCs) from oxidative injury. vitro stress RBCs was induced by water-soluble radical initiator 2,2'-azo-bis(2-amidinopropane) dihydrochloride. RBC...
Physical activity is important in obesity prevention, but the effectiveness of different physical modalities remains to be determined among children. The main purpose this study was compare effects a 6-month soccer programme and traditional on changes body composition, cardiometabolic risk factors, inflammatory oxidative markers, cardiorespiratory fitness perceived psychological status obese boys. Eighty-eight boys (8-12 years; BMI > +2 standard deviations WHO reference values) participated...
End-stage renal disease (ESRD) patients under hemodialysis (HD) have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status been reported these patients. Our aim was to identify any significant association of death with disturbances, by performing a two-year follow-up study. A large set data obtained from 189 HD (55.0% male; 66.4 ± 13.9 years old), including hematological data, lipid profile, nutritional,...
Recent studies of chitosan have increased the interest in its conversion to chitooligosaccharides (COSs) because these compounds are water-soluble and potential use several biomedical applications. Furthermore, such oligomers may be more advantageous than chitosans their much higher absorption profiles at intestinal level, which permit facilitated access systemic circulation distribution throughout entire human body. In that perspective, it is important clarify effect on blood further,...
Aim: The aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance recombinant human erythropoietin (rhEPO) therapy.Methods: We studied 63 CKD hemodialysis rhEPO treatment (32 responders 31 non-responders therapy).In 20 CIO (10 10 therapy), blood samples were also collected immediately after dialysis.Twenty-six healthy volunteers included a control group.Hemoglobin levels, total differential...
End-stage renal disease (ESRD) under hemodialyses (HD) is related with a higher propensity to infections, essentially due T-cell lymphopenia. We postulated that HD procedure affects CD4+ T cells, especially by inducing apoptotic death and recombinant human erythropoietin (rhEPO) therapy may also play an important role in the modulation of immune system these patients. phenotype apoptosis patients healthy controls were evaluated flow cytometry using anticoagulated whole-blood samples. In 12...
Objectives Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels recent evidence suggests that raised adiposity may also be contributing factor. We aimed to study interaction between UGT1A1 polymorphism, hematological anthropometric variables with total young individuals. Methods 350 obese (mean age 11.6 years; 52% females) 79 controls 10.5 59% were included. Total...
The genetic contribution to obesity and circulating adipokine levels has not been completely clarified. We aimed evaluate genes' single-nucleotide polymorphism (SNP) prevalence its association with risk factors for cardiovascular disease in an obese Portuguese pediatric population.Two hundred forty-eight adolescents (mean age 13.4 years old; 47.2% females) participated a cohort study. screened 12 SNPs by direct sequencing five genes: adiponectin (ADIPOQ: rs16861194, rs17300539, rs266729,...
DNA damage and inflammation are common in end-stage renal disease (ESRD). Our aim was to evaluate the levels of circulating cell-free (cfDNA) relationship with inflammation, anaemia, oxidative stress haemostatic disturbances ESRD patients on dialysis. By performing a 1-year follow-up study, we also aimed predictive value cfDNA for outcome patients. A total 289 dialysis were enrolled study: evaluated cfDNA, haemogram, serum iron, hepcidin, inflammatory markers, haemostasis. Events causes...
to evaluate whether total and differential WBC counts are altered in young obese patients (aged 6-12 years) if a relationship exists between the severity of obesity as well with CRP level.a group 77 [32 males 45 females] 19 controls [7 12 were studied. Total count was performed by using an automatic blood cell counter. Blood morphology evaluated Wright stained films. The plasma levels immunoturbidimetry.obese participants presented statistically significant higher neutrophil percentage when...
Abstract Chronic kidney disease ( CKD ) has been associated with an abnormal lipid profile. Our aim was to study the interplay between oxidized low‐density lipoprotein ox‐LDL ), adiponectin, and blood lipids lipoproteins in Portuguese patients under hemodialysis HD ); influence of pentanucleotide repeat polymorphism apolipoprotein(a) apo [a] gene upon lipoprotein(a) Lp[a] levels these patients. We studied 187 25 healthy individuals. adiponectin were measured using enzyme‐linked immunoassays....
Objectives: Evaluate cardiovascular risk factors in Portuguese obese children and adolescents the long-term effects of lifestyle modifications on such factors.
Bilirubin can prevent lipid oxidation in vitro, but the association vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to of Ox-LDL total bilirubin (TB) and variables related metabolic syndrome inflammation, young obese individuals. 125 patients (13.4 years; 53.6% females) were studied. TB, profile including Ox-LDL, markers glucose metabolism, C-reactive protein (CRP) adiponectin determined. Anthropometric data was also collected. In all patients,...
Purpose: There are few reliable studies assessing the effect of physical exercise (PE) on adipokines levels at young ages. Our objective was to study effects regular PE plasma in pediatric overweight and obesity. Method: 117 obese children adolescents (47% females; 10.2 years) participated an 8-month longitudinal divided two groups: group ( n = 80), engaged after-school program; control 37), with no program. Plasma lipids, C-reactive protein (CRP), adiponectin, resistin, leptin, IL-6,...
Aim: To determine the effects of a school-based exercise intervention programme on cardiovascular risk factors, including body fat (BF), metabolic profile and physical activity (PA) in children with without individualised dietary counselling approach (IDC WIDC).Subjects methods: Forty-six overweight from 6–16 years old (25 girls, 54.3%; age = 10.3 ± 2.8) six schools took part an 8-month interdisciplinary, programme. All were engaged PA classes, but only one group was exposed to counselling....
<b><i>Background/Aims:</i></b> Cardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic non-genetic factors; however, how these factors influence PON1 HD is poorly clarified. Our aim was to evaluate two polymorphisms <b><i>Methods:</i></b> We evaluated 183 under recombinant human erythropoietin (rhEPO) treatment 22...
We evaluated the potential cardiovascular risk protection of bilirubin in hemodialysis (HD) patients. An enlarged set studies were 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy. The TA duplication screening UDP-glucuronosyltransferase 1 A1 ( UGT1A1 ) promoter region was also performed. genotype frequencies patients 49.2%, 42.4%, 8.4% for 6/6, 6/7, 7/7 genotypes, respectively. Although no difference...
<h3>Objective</h3> To evaluate how the lipid profile associates with apolipoprotein (apo) E gene polymorphism, plasma adiponectin level, and body mass index (BMI)<i>z</i>score in Portuguese youth. <h3>Design</h3> Transversal cohort study. <h3>Setting</h3> Hospital de São João Crianças Maria Pia, Porto, Portugal, between May 2006 March 2007. <h3>Participants</h3> One hundred thirty-eight obese children adolescents (62 boys; mean age, 10.8 years [range, 4-16 years]). Participants were grouped...