A5062004576- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- X-ray Diffraction in Crystallography
- Pancreatic and Hepatic Oncology Research
- Crystallization and Solubility Studies
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- TGF-β signaling in diseases
Lanzhou University
2013-2025
Lanzhou University Second Hospital
2013-2025
Gansu Province Computing Center
2023
Sichuan University
2011
First Hospital of Lanzhou University
2005
Abstract Macrophages constitute a major component of tumor-infiltrating immune cells. M2 macrophages have been reported to promote tumor progression through promoting angiogenesis and metastasis regulating T-cell function. Here, we identified protumorigenic subset that constitutively expressed programmed cell death 1 (PD1) accumulated in advanced-stage gastric cancer (GC). These PD1 + tumor-associated (TAMs) exhibited an M2-like surface profile, with significant increase the expression...
Abstract Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt inhibitors being studied preclinical or clinical settings for other cancers such as colorectal and pancreatic are either too cytotoxic insufficiently efficacious GC. Thus, we screened new potent targets from β-catenin destruction complex associated with GC progression samples, found that scaffolding protein RACK1 deficiency plays a significant role...
Trastuzumab is the backbone of HER2-directed gastric cancer therapy, but poor patient response due to insufficient cell sensitivity and drug resistance remains a clinical challenge. Here, we report that HER2 involved in mitotic promotion for tumorigenesis by hyperactivating crucial HER2-SHCBP1-PLK1 axis drives trastuzumab targeted therapeutically. SHCBP1 an Shc1-binding protein detached from scaffold Shc1 following activation. Released responds cascade translocating into nucleus Ser273...
Pancreatic cancer (PC) is a highly lethal malignancy with rapid progression and poor prognosis. Despite the widespread use of gemcitabine (Gem)-based chemotherapy as first-line treatment for PC, its efficacy often compromised by significant drug resistance. 1,2,3,4,6-Pentagaloyl glucose (PGG), natural polyphenol, has demonstrated potential in sensitizing PC cells to Gem. However, clinical application limited water solubility bioavailability. In this study, we developed novel PGG-based...
Introduction: Docetaxel, oxaliplatin, leucovorin, and 5-fluorouracil (FLOT) may improve overall survival (OS) in patients with locally advanced gastric cancer (LAGC); however, evidence for its use as a standard treatment has not been established China. The aim of this study was to investigate the effectiveness, safety, feasibility FLOT regimen neoadjuvant chemotherapy Chinese resectable LAGC. Methods: We conducted an observational compare effectiveness consisting docetaxel (60 mg/m 2, ),...
Eg5, also known as KIF11, is a motor protein essential for establishing bipolar spindle and ensuring proper chromosome congression during mitosis. It amplified in various human cancers serves critical oncogene driving tumour progression. However, the role clinical significance of Eg5 gastric cancer has remained elusive. In this study, we showed that upregulation tissues negatively associated with patient prognosis. The ablation inhibits proliferation migration cells suppresses growth...
Matrine has potent antitumor activity against a broad variety of cancer cells and our previous study showed that both autophagy apoptosis were activated during matrine-induced gastric cell death. The aim the present was to determine significance in antineoplastic effects matrine molecular mechanism by which induces cells. Western blot analysis exposure resulted extent increasing dose- time-dependent manner detecting microtubule-associated protein 1 light chain 3 (LC3). This induction due...
Abstract The chemotherapeutic agent 5-fluorouracil (5-FU) remains the backbone of postoperative adjuvant treatment for gastric cancer. However, fewer than half patients with cancer benefit from 5-FU–based chemotherapies owing to chemoresistance and limited clinical biomarkers. Here, we identified SNF2 protein Polo-like kinase 1-interacting checkpoint helicase (PICH) as a predictor 5-FU chemosensitivity characterized transcriptional function PICH distinct its role in chromosome separation....
Abstract The crucial role of cancer‐associated fibroblasts (CAFs) in promoting T‐cell exclusion has a significant impact on tumor immune evasion and resistance to immunotherapy. Therefore, enhancing infiltration into solid tumors emerged as pivotal area research. We achieved conventional knockout Shcbp1 ( −/− ) through CRISPR/Cas9 gene editing crossed these mice with spontaneous breast cancer MMTV‐PyMT mice, resulting PyMT mice. different CAF subtypes were detected by flow cytometry analysis...
The diffuse-type gastric cancer (DGC) is a subtype of (GC) associated with low HER2 positivity rate and insensitivity to chemotherapy immune checkpoint inhibitors. Here, we identify urokinase-type plasminogen activator receptor (uPAR) as potential therapeutic target for DGC. We have developed novel anti-uPAR monoclonal antibody, which targets the domains II III uPAR blocks binding uPAR. show that combination anti-Programmed cell death protein 1 (PD-1) remarkably inhibits tumor growth...
Gastric cancer is one of the most common lethal malignancies in world, especially China. Due to ineffective screening early gastric and drug resistance advanced, prognosis remains dismal. Based on bioinformatics tissue microarray analyses, FBXO5 was selected for analysis this study. Here, we report function cancer, showing first time that it contributes tumor cell proliferation, clone formation, invasion migration. In these preliminary findings, promoted transition cycle from G0/G1 G2/M...
Abstract Transition‐metal‐catalyzed C−H functionalization of aromatic secondary amides with alkynes mainly undergo C−H/N−H annulation but rarely ortho‐alkenylation. It is particularly challenging to selectively realize both oxidative and ortho‐alkenylation in the transition‐metal‐catalysis. In this article, we synthesized fully‐substituted 2‐pyridones 2,6‐naphthyridine‐1,5‐diones via C(sp 2 )−H fumaramides for first time. Under Ru‐catalysis, 1,2‐diaryl ethynes leading intermediate 2‐pyridone...
Although there are several treatments available for gastric cancer (GC), the prognosis of disease is still poor due to many factors, such as late diagnosis and tumor heterogeneity. To identify potential therapeutic targets, bioinformatics techniques clinical sample validation were employed prostate transmembrane protein androgen induced 1 (PMEPA1) was selected further study. In present study, we found that elevated PMEPA1 expression correlates with a worse weaker anti-tumor immunity in GC...
Abstract Pancreatic cancer (PC) is a highly aggressive and deadly malignancy with limited treatment options poor prognosis. Identifying new therapeutic targets developing effective strategies for PC of utmost importance. Here, we revealed that SHCBP1 significantly overexpressed in negatively correlated patient Knockout inhibits the proliferation migration cells vitro, suppresses tumor growth vivo. In addition, identified AZD5582 as novel inhibitor SHCBP1, which efficiently restrains cell...
The mechanism underlying the poor prognosis of gastric cancer, including its high degree malignancy, invasion, and metastasis, is extremely complicated. Rho GTPases are involved in occurrence development a variety malignant tumors. ARHGAP11A, GTPase activating protein family, highly expressed but function have not yet been explored. In this study, effect ARHGAP11A on cancer related to were studied. expression was increased cells tissues, tissues tumor differentiation prognosis. Moreover,...