A5006528309- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Vitamin D Research Studies
- Pharmacology and Obesity Treatment
- Epigenetics and DNA Methylation
- Thyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Acute Myocardial Infarction Research
- Bariatric Surgery and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Congenital heart defects research
- Kruppel-like factors research
- Biotin and Related Studies
- Hypothalamic control of reproductive hormones
- Smoking Behavior and Cessation
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Ubiquitin and proteasome pathways
- Animal Genetics and Reproduction
- Genetics and Neurodevelopmental Disorders
- Photodynamic Therapy Research Studies
Syneos Health (United States)
2024
Population Health Research Institute
2018-2023
Hamilton Health Sciences
2020-2023
University of California, Los Angeles
2011-2022
VA Greater Los Angeles Healthcare System
2011-2022
McMaster University
2014-2021
Health Sciences Centre
2021
University of Manitoba
2021
Western University of Health Sciences
2021
Western University
2021
Background and Purpose- Aortic arch atherosclerosis (AAA) is a possible source of embolism in patients with embolic stroke undetermined source. Previous studies reported high rates events AAA, especially those high-risk AAA. This exploratory analysis NAVIGATE ESUS (New Approach Rivaroxaban Inhibition Factor Xa Global Trial Versus ASA to Prevent Embolism Embolic Stroke Undetermined Source) focused on AAA assessed their characteristics, recurrence rates, response treatment. Methods- The...
The reported associations of cerebral microbleeds with recurrent stroke and intracerebral hemorrhage have raised concerns regarding antithrombotic treatment in patients a history on magnetic resonance imaging.To characterize embolic strokes undetermined source (ESUS) report interactions between the effects random assignment to anticoagulant vs antiplatelet therapy.Subgroup analyses New Approach Rivaroxaban Inhibition Factor Xa Global Trial Aspirin Prevent Embolism ESUS (NAVIGATE ESUS)...
Abstract Traumatic brain injury (TBI) is associated with disruption of cerebral blood flow leading to localized hypoxia. Thyroid hormone (TH) treatment, administered shortly after injury, has been shown promote neural protection in rodent TBI models. The mechanism TH protection, however, not established. We used mouse primary cortical neurons investigate the effectiveness and possible pathways T3-promoted cell survival exposure hypoxic injury. Cultured were exposed hypoxia (0.2% oxygen) for...
To examine diabetes remission following a short-term intensive metabolic intervention combining lifestyle and glucose-lowering approaches.We conducted an open-label, randomized controlled trial in 154 patients with type 2 up to 8 years duration on 0 medications. Participants were (a) 12-week comprising approaches treatment insulin glargine, metformin, dapagliflozin or (b) standard care. At 12 weeks, medications discontinued participants hemoglobin A1c (HbA1C) < 7.3% (56 mmol/mol). then...
Abstract Aim Non‐surgical options for inducing type 2 diabetes remission are limited. We examined whether can be achieved by combining lifestyle approaches and short‐term intensive glucose‐lowering therapy. Methods In this trial, 160 patients with on none to two medications other than insulin were randomised (a) an intervention comprising approaches, glargine/lixisenatide metformin, or (b) standard care. Participants glycated haemoglobin (HbA1c) <7.3% (56 mmol/mol) at 12 weeks asked stop...
Background Branch atheromatous disease (BAD) is distinctive from large and small arterial diseases, which single subcortical infarction larger than lacunar stroke in the territories of deep perforators without relevant stenosis. BAD meets current criteria embolic undetermined source. We performed an exploratory analysis patients recruited to NAVIGATE source, a randomized controlled trial compare rivaroxaban aspirin source patients. Methods results Among 3972 cerebral hemispheres with...
1α-hydroxymethyl-25-hydroxyvitamin D3 and 1β-hydroxymethyl-3α,25-hydroxyvitamin D3, two analogs with modifications restricted to the A ring, bind poorly vitamin D receptor (VDR). The effective doses required for 50% of maximal binding activity (ED50) are 7 x 10-7 M former 8 10-8 latter, ED50 their growth-inhibitory activities is greater than 10-6 M. Unexpectedly, a hybrid analog 20-epi configuration at its side chain 1β-hydroxymethyl group but not 1α-hydroxymethyl inhibits malignant cell...
Twenty-epi analogs of 1α,25-dihydroxyvitamin D3 (1,25D3) are 100-1000 times more potent transcriptionally than the natural hormone. To determine whether this enhanced activity is mediated through modulation dimerization process or interaction with coactivators, we performed quantitative protein-protein assays in vitro translated vitamin D receptor (ivtVDR) and fusion proteins containing glutathione-S-transferase (GST) either ligand-binding domain retinoid X (RXRα), nuclear...
Smoking is a significant public health concern. The Ontario Pharmacy Cessation Program was launched in September 2011 to leverage community pharmacists and expand access smoking cessation services for drug plan beneficiaries.We examined care utilization data describe beneficiaries receiving, pharmacies providing, between 2013. Patient characteristics were summarized, stratified by group: seniors (age ≥65 years) or social assistance. Trends over time plotting the number of services, unique...
The aim of the study was to evaluate remission type 2 diabetes following a short-term intervention with insulin glargine, sitagliptin/metformin, and lifestyle approaches.In this open multicenter trial, 102 patients were randomized 1) 12-week therapy or 2) control group. Participants HbA1c <7.3% (<56 mmol/mol) at 12 weeks asked stop medications followed for evidence relapse over 52 weeks. Diabetes criteria included ≥6.5% (≥48 mmol/mol), ≥50% capillary glucose readings >10 mmol/L 1 week,...
Thyroid hormone receptor β (THRB) is posttranslationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with mutation that disrupted sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form tissues. The K146Q mutant mice had normal serum thyroxine (T4), markedly elevated thyrotropin-stimulating (TSH; 81-fold above control), enlargement of both pituitary thyroid gland. marked elevation TSH, despite T4, indicated blunted feedback...
Kallikrein-binding protein (KBP) is a component of the kallikrein-kinin system that mediates vasodilation and inhibits tumor growth by antagonizing vascular endothelial factor-mediated angiogenesis. We demonstrate KBP gene expression repressed T(3) modulated orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1). In hypothyroid mice, mRNA in testis was increased 2.1-fold compared with euthyroid mice. have identified two negative thyroid hormone...
Background: Thyroid hormone is critical for normal brain development and acts in a spatial temporal specific pattern. excess, or deficiency, can lead to irreversible impairment of sensory development. Chicken ovalbumin upstream-transcription factor 1 (COUP-TF1), expressed early neuronal development, essential achieve structure. stimulation gene expression inversely correlated with the level COUP-TF1 expression. Methods: An vitro method differentiating mouse embryonic stem (mES) cells into...
<h3>Importance</h3> Patients with shorter ischemic times have a greater viable myocardium and may derive benefit from thrombus aspiration. <h3>Objective</h3> To study the association of aspiration outcomes among patients presenting ST-segment elevation myocardial infarction (STEMI) based on time. <h3>Design, Setting, Participants</h3> The TOTAL (Thrombectomy With PCI vs Alone in STEMI) trial was an international randomized clinical 10 732 STEMI undergoing primary percutaneous coronary...
Thyroid hormone has been shown to have a protective role in neuronal injury, although the mechanisms not established. The cellular response stress that promotes adaptation and survival involve epigenetic modifications.We hypothesized neuroprotective of thyroid was associated with modifications histone proteins. We used hypoxic neurons as model system for hypoxia-induced brain injury.Mouse primary cortical were exposed 0.2% oxygen 7 hours, or without, treatment triiodothyronine (T3). analyzed...
Abstract Objective To describe treatment patterns and direct healthcare costs over 3 years following initiation of standard care acute preventive migraine medications in patients with the United States. Background There are limited data on long‐term (>1 year) treatments associated outcomes. Methods This was a retrospective, observational cohort study using US claims from IBM ® MarketScan Research Database (January 2010–December 2017). Adults were included if they had prescription claim...
Background: Cerebral microbleeds (CMBs) are reported to predict recurrent stroke and antithrombotic-related intracerebral hemorrhage (ICH). We characterize CMBs in a well-defined population of embolic strokes undetermined source (ESUS). Notably, we report for the first time interactions between effects random assignment anticoagulant therapy. Methods: Subgroup analyses NAVIGATE ESUS randomized trial comparing rivaroxaban 15 mg vs. aspirin 100 daily were performed. rated on T2*-GRE sequences...
Background: Diabetes remission due to non-surgical approaches has not been well studied. We investigated induction of diabetes following a short-term treatment with insulin glargine, lixisenatide and metformin changes in exercise dietary behaviours. Methods: randomized 160 individuals type 2 (i) 12-week intensive lixisenatide, lifestyle or (ii) standard glycemic management. At 12 weeks, medications were stopped patients HbA1C&lt;7.3%, participants followed for relapse over the subsequent...
<b>Objective</b> <p>The aim of the study was to evaluate remission type 2 diabetes following a short-term intervention with insulin glargine, sitagliptin/metformin and lifestyle approaches.</p> <p> </p> <p><b>Research Design Methods</b></p> <p>In this open multicenter trial, 102 patients were randomized (i) 12-week sitagliptin/metformin, glargine therapy or (ii) control group. Participants HbA1C<7.3% [<56 mmol/mol] at 12...
No standard practice exists with respect to anaesthesiologist-directed sedation (ADS) vs. by proceduralist (PDS) for defibrillation threshold (DT) testing. We aimed evaluate adverse events and safety outcomes ADS PDS DT A post hoc analysis of the Shockless Implant Evaluation (SIMPLE) study was performed among 1242 patients who had testing (624 618 PDS). evaluated both intraoperative in-hospital composite two at 30-days main trial. Propensity score adjusted models were used compute odds ratio...