A5018412506- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Adolescent and Pediatric Healthcare
- Acute Lymphoblastic Leukemia research
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- T-cell and Retrovirus Studies
- Adrenal Hormones and Disorders
- Animal Disease Management and Epidemiology
- CAR-T cell therapy research
- Kawasaki Disease and Coronary Complications
- Inflammatory Myopathies and Dermatomyositis
- Diabetes and associated disorders
- Heat shock proteins research
- Vascular Anomalies and Treatments
- Immunodeficiency and Autoimmune Disorders
- Ocular Diseases and Behçet’s Syndrome
- Cancer-related gene regulation
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- Neurogenetic and Muscular Disorders Research
- Inflammasome and immune disorders
University of California, San Francisco
2011-2024
Children's Hospital of Philadelphia
2024
University of Pennsylvania
2024
Dalhousie University
2022
Izaak Walton Killam Health Centre
2022
University of Alabama at Birmingham
2022
Hackensack University Medical Center
2021
University College London
2009
Ludwig Cancer Research
2007
Pennsylvania State University
2001-2006
The COPA syndrome is a monogenic, autoimmune lung and joint disorder first identified in 2015. This study sought to define the main pulmonary features of an international cohort patients, analyse patient responses treatment highlight when genetic testing should be considered. We established subjects (N=14) with seen at multiple centres including University California, San Francisco, CA, USA. All had one previously mutations gene, clinically apparent disease arthritis. analysed...
Abstract The promising antitumor activity of 17-allylamino-17-demethoxygeldanamycin (17AAG) results from inhibition the molecular chaperone heat shock protein 90 (HSP90) and subsequent degradation multiple oncogenic client proteins. Gene expression microarray proteomic analysis were used to profile changes in A2780 human ovarian cancer cell line treated with 17AAG. Comparison an inactive analogue alternative HSP90 inhibitor radicicol indicated that increased HSP72, HSC70, HSP27, HSP47,...
IκB kinase (IKK), a key regulator of immune and inflammatory responses, is known as an effector mediating activation the transcription factor NF-κB. Whether IKK also participates in other signaling events not known. Here we show that serves essential component pathway involves Tpl2 its downstream targets, MEK1 ERK. Inhibition IKKβ macrophages eliminates ERK phosphorylation induced by lipopolysaccharide tumor necrosis alpha. Using IKK-deficient murine fibroblasts, further demonstrate IKKβ,...
Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an role in this process by driving expression of a diverse set tissue-specific antigens (TSAs), which are presented and help tolerize self-reactive thymocytes. Interestingly, Aire has highly tissue-restricted pattern expression, with only mTECs peripheral extrathymic Aire-expressing (eTACs) known express detectable levels adults. Despite...
The Tax oncoprotein encoded by human T-cell leukemia virus induces both activation and apoptosis. mechanism which apoptosis has remained unclear. Using genetically manipulated lines, we demonstrate that Tax-induced death is dependent on NF-κB signaling. fails to induce in T cells lacking IκB kinase γ (IKKγ), an essential component of the signaling pathway. This defect was rescued when mutant were reconstituted with exogenous IKKγ. We further mediated TNF (tumor necrosis factor)-related...
We conducted a comprehensive gene expression meta-analysis in dermatomyositis (DM) muscle and skin tissues to identify shared disease-relevant genes pathways across tissues.Six publicly available data sets from DM two were identified. Meta-analysis was performed by first processing individually then cross-study normalization merging creating tissue-specific matrices for subsequent analysis. Complementary single-gene network analyses using Significance Analysis of Microarrays (SAM) Weighted...
Protein kinase Tpl2/Cot is encoded by a protooncogene that cis-activated retroviral insertion in murine T cell lymphomas. It has remained unclear whether this oncoprotein mutated or post-translationally activated human cancer cells. We have shown here constitutively leukemia lines transformed the virus type I (HTLV-I). The activity of normally suppressed through its physical interaction with an inhibitor, NF-kappaB1 precursor protein p105. Interestingly, large pool liberated from p105 and...
T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute the pathogenesis of multiple autoimmune diseases and targeted therapeutically. Due role Th17 in pathogenesis, it is important understand factors that control development. Here we identify activating transcription factor 7 interacting protein (ATF7ip) as a regulator differentiation. Mice with cell–specific deletion Atf7ip impaired differentiation secondary...
Mutations in the gene encoding zinc-finger transcription factor Ikaros (
CD8
Abstract Central tolerance is critical to prevent autoimmunity, but limits T cell responses tumor Ag that are self Ag. We have identified gamma-interferon-inducible lysosomal thiol reductase (GILT) required for thymic deletion of CD4+ cells specific the and melanoma Ag, tyrosinase-related protein 1 (TRP1). To define GILT’s role in central tolerance, we show GILT expression enriched APC capable mediating deletion, medullary epithelial (mTEC) dendritic cells. TRP1 restricted mTEC. facilitates...