A5102804986- Renal Transplantation Outcomes and Treatments
- Pain Management and Opioid Use
- Mitochondrial Function and Pathology
- Nausea and vomiting management
- Cutaneous lymphoproliferative disorders research
- Anesthesia and Pain Management
- Genetics, Aging, and Longevity in Model Organisms
- Central Venous Catheters and Hemodialysis
- Neurological Complications and Syndromes
- Photosynthetic Processes and Mechanisms
- Dialysis and Renal Disease Management
- Nail Diseases and Treatments
- Pharmacological Effects and Toxicity Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Diagnosis and Treatment of Venous Diseases
- Metabolomics and Mass Spectrometry Studies
- Venous Thromboembolism Diagnosis and Management
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Autoimmune Bullous Skin Diseases
- Chemical Synthesis and Analysis
- Transplantation: Methods and Outcomes
- Biomedical and Chemical Research
Robert Bosch Hospital
2023
Université de Rennes
2018-2019
Centre National de la Recherche Scientifique
2018-2019
Heidelberg University
2010-2019
University Hospital Heidelberg
2012-2019
Institut de génétique et de développement de Rennes
2018-2019
Nephrologisches Zentrum Emsland
2004-2017
University Children's Hospital Zurich
2012-2016
Praxis
2015
University Medical Centre Mannheim
2012
Gene-inactivation studies point to the involvement of OxyB in catalyzing first oxidative phenol coupling reaction during glycopeptide antibiotic biosynthesis. The oxyB gene has been cloned and sequenced from vancomycin producer Amycolatopsis orientalis, hemoprotein produced Escherichia coli, crystallized, its structure determined 1.7-A resolution. gave UV-visible spectra characteristic a P450-like low spin ferric state. After reduction ferrous state by dithionite or spinach ferredoxin...
OxyB is a cytochrome P450 enzyme that catalyzes the first phenol coupling reaction during biosynthesis of vancomycin-like glycopeptide antibiotics. The occurs on linear peptide intermediate linked as C-terminal thioester to carrier protein (PCP) domain within multidomain nonribosomal synthetase (NRPS). Using model peptides with sequence (R)(NMe)Leu-(R)Tyr-(S)Asn-(R)Hpg-(R)Hpg-(S)Tyr-S-PCP and (R)(NMe)Leu-(R)Tyr-(S)Asn-(R)Hpg-(R)Hpg-(S)Tyr-(S)Dpg-S-PCP (where Hpg = 4-hydroxyphenylglycine, Dpg...
Efficient removal of beta 2 microglobulin (beta 2-M) in end-stage renal failure patients is a continuing preoccupation, as the incidence and severity dialysis-associated amyloidosis are increasing. To evaluate comparative 2-M we studied six stable during high-flux 3-h haemodialysis, haemodia-filtration, haemofiltration, using acrylonitrile, cellulose triacetate, polyamide polysulphone capillary devices. The reduction plasma 2-M, total ultrafiltrate/dialysate, sieving coefficients were...
Intestine function relies on the strong polarity of intestinal epithelial cells and array microvilli forming a brush border at their luminal pole. Combining genetic RNAi screen in vivo super-resolution imaging C. elegans intestine, we uncovered that V0 sector V-ATPase (V0-ATPase) controls late apical trafficking step, involving RAB-11+ endosomes SNARE SNAP-29, necessary to maintain polarized localization both modules proteins. We show V0-ATPase pathway also genetically interacts with...
Obstetric complications play a role in the pathophysiology of schizophrenia. However, biological consequences during neurodevelopment until adulthood are unknown. Microarrays have been used for expression profiling four brain regions rat model neonatal hypoxia as common factor obstetric complications. Animals were repeatedly exposed to chronic from postnatal (PD) day 4 through 8 and killed at age 150 days. Additional groups rats treated with clozapine PD 120–150. Self-spotted chips...
Primary cutaneous B-cell lymphomas (PCBCL) are subdivided into the aggressive form, primary diffuse large lymphoma, leg type (PCLBCL, LT) and two subtypes of indolent behaviour (primary follicle centre lymphoma marginal zone lymphoma). The difference in clinical can be explained by tumour cell itself, or microenvironment including antitumour immune response.To investigate presence regulatory T cells (Treg), CD4+CD25+FOXP3+, PCBCL correlation with outcome.Tumour specimens 55 consecutive cases...
AimsInfarct-remodelled hearts are less amenable to protection against ischaemia/reperfusion. Understanding preservation of energy metabolism in diseased vs. healthy may help develop anti-ischaemic strategies effective also jeopardized myocardium.
<b><i>Background/Aims:</i></b> Up to 50% patients requiring dialysis receive an urgent, unplanned start (UPS) renal replacement therapy (RRT). Most of these are initiated with intravenous catheter and commenced maintained on hemodialysis (HD). Although peritoneal (PD) could be equipotent initial modality for RRT, it is used less frequently as long-term RRT in UPS patients. This multicenter-study aimed evaluate the impact a structured, in-hospital education program...
Newborn screening for MSUD is a special challenge since patients with can metabolically decompensate rapidly without adequate treatment within the first two weeks of life. However, method does not detect actual marker metabolite (alloisoleucine) specifically, but only as part group other isobaric amino acids leucine, isoleucine and hydroxyproline. We describe sensitive rapid second-tier UPLC-MS/MS to determine branched-chain from initial extraction sample. Quantification based on seven-point...
Abstract Intestine function relies on the strong polarity of intestinal epithelial cells and array microvilli forming a brush border at their luminal pole. Combining genetic RNAi screen in vivo super-resolution imaging C . elegans intestine, we uncovered that V0 sector V-ATPase (V0-ATPase) controls late apical trafficking step, involving RAB-11 endosomes SNARE SNAP-29, necessary to maintain polarized localization both modules proteins. We show V0-ATPase pathway also genetically interacts...