A5083545376- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Optical Imaging and Spectroscopy Techniques
- Infant Development and Preterm Care
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Infant Nutrition and Health
- COVID-19 Impact on Reproduction
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Heart Disease Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Healthcare Technology and Patient Monitoring
- Ethics in Clinical Research
- Congenital Anomalies and Fetal Surgery
- Knee injuries and reconstruction techniques
- Gut microbiota and health
- Arts, Culture, and Music Studies
- Cardiac Arrest and Resuscitation
- Bone fractures and treatments
- Meta-analysis and systematic reviews
- German Literature and Culture Studies
- Gastrointestinal motility and disorders
- Drug-Induced Adverse Reactions
- Cinema and Media Studies
- Pleural and Pulmonary Diseases
Copenhagen University Hospital
2018-2024
Rigshospitalet
1979-2024
University of Copenhagen
2021-2023
The Capital Region Pharmacy
2019-2020
Children's Hospital of Fudan University
2019-2020
Hospital Universitario La Paz
2019-2020
The First People's Hospital of Zhaoqing
2019-2020
Children’s Hospital of Fudan University Xiamen Branch
2019-2020
Herlev Hospital
2018
University of Applied Sciences Worms
2007-2008
The use of cerebral oximetry monitoring in the care extremely preterm infants is increasing. However, evidence that its improves clinical outcomes lacking. Download a PDF Research Summary. In this randomized, phase 3 trial conducted at 70 sites 17 countries, we assigned (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by for first 72 birth or usual care. primary outcome was composite death severe brain injury on ultrasonography 36 weeks' postmenstrual...
Journal Article Early cinema, late cinema: permutations of the public sphere Get access Miriam Hansen Search for other works by this author on: Oxford Academic Google Scholar Screen, Volume 34, Issue 3, Autumn 1993, Pages 197–210, https://doi.org/10.1093/screen/34.3.197 Published: 01 October 1993
Abstract Background Cerebral oxygenation monitoring may reduce the risk of death and neurologic complications in extremely preterm infants, but no such effects have yet been demonstrated infants sufficiently powered randomised clinical trials. The objective SafeBoosC III trial is to investigate benefits harms treatment based on near-infrared spectroscopy (NIRS) compared with as usual for infants. Methods/design an investigator-initiated, multinational, randomised, pragmatic phase trial....
It has been hypothesised that the gut microbiota causally affects obesity via its capacity to extract energy from diet. Yet, evidence elucidating role of particular human microbial community structures and determinants microbiota-dependent harvest is lacking.Here, we investigated whether extraction diet in 85 overweight adults, estimated by dry stool density, was associated with intestinal transit time variations diversity overall structure stratified as enterotypes. We a slower would allow...
Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks gestational age) differed in neonatal intensive care units (NICUs) SafeBoosC-III consortium during global lockdown when compared to corresponding time period 2019. Design: This is a retrospective, observational study. Forty-six out 79 NICUs (58%) from 17 countries participated. Principal investigators were asked report following information: (1) Total EP infant admissions their NICU 3 months...
The Safeguarding the Brains of our smallest Children (SafeBoosC) project was initially established to test patient-relevant benefits and harms cerebral oximetry in extremely preterm infants setting a randomized clinical trial. Extremely constitute small group patients with high risk death or survival brain injury subsequent neurodevelopmental disability. Several oximeters are approved for use, but use additional equipment may disturb thereby possibly harm these vulnerable, immature patients....
Diets rich in whole grains are associated with health benefits. Yet, it remains unclear whether the benefits mediated by changes gut function and fermentation.We explored effects of whole-grain vs. refined-grain diets on markers colonic fermentation bowel function, as well their associations microbiome.Fifty overweight individuals increased metabolic risk a high habitual intake (~69 g/day) completed randomised cross-over trial two 8-week dietary intervention periods comprising diet (≥75 (<10...
Abstract Aim Necrotising enterocolitis ( NEC ) is often staged according to Bell's 1978 system, but today's cases are more immature than the ones that were used develop stages. Our aim was explore clinical and radiographic findings of contemporary spontaneous intestinal perforation. Methods We coded records all stages I– III perforation born in 2006–2015 at tertiary department neonatology Rigshospitalet, Denmark, for 16 symptoms signs disease onset climax. These variables explored using...
Necrotising enterocolitis contributes considerably to the mortality of preterm infants, but most questions remain unsolved after decades extensive research. This Danish study investigated validity necrotising diagnoses at discharge according Bell's staging system.We conducted a retrospective single-centre cohort 714 infants with gestational age less than 30 weeks born in 2006-2013. The were diagnosed stages 2-3 and retrospect by an expert panel, which served as our gold standard.The...
Abstract Background In the SafeBoosC-III trial, treatment guided by cerebral oximetry monitoring for first 72 hours after birth did not reduce incidence of death or severe brain injury in extremely preterm infants at 36 weeks’ postmenstrual age, as compared with usual care. Despite an association between diagnosed neonatal period and later neurodevelopmental disability, this relationship is always strong. The objective follow-up study to assess mortality, any harm trial participants 2 years...
Complications in the biliary tract occur 5%-30% after liver transplantation and main part of complications is successfully managed with endoscopic retrograde cholangiopancreaticography (ERCP). The incidence risk factors for post-ERCP patients are not well described. Our objective was to define frequency at Abdominal Center, Rigshospitalet, only Liver Transplantation Center Denmark.Retrospective study all ERCPs performed during a 9-year period.A total 292 were included. Overall occurred 24...
Abstract Background The process of obtaining prior informed consent for experimental treatment does not fit well into the clinical reality acute and intensive care. therapeutic window interventions is often short, which may reduce validity rate enrolled participants, to delay trial completion external results. Deferred ‘opt-out’ are alternative methods. SafeBoosC-III was a randomised investigating benefits harms cerebral oximetry monitoring in extremely preterm infants during first 3 days...
Abstract Background Data monitoring of clinical trials is a tool aimed at reducing the risks random errors (e.g. clerical errors) and systematic errors, which include misinterpretation, misunderstandings, fabrication. Traditional ‘good practice data monitoring’ with on-site monitors increases trial costs time consuming for local investigators. This paper aims to outline our approach time-effective central SafeBoosC-III multicentre randomised present results from first three meetings. Methods...
Aim The aim of this study was to evaluate long-term behavioural and neurodevelopmental complications neonatal necrotizing enterocolitis at school age. Method This a historic cohort comparing all surviving children born in Denmark between 1st January 2002 31st December 2011 with diagnosis group without enterocolitis, but same gestational age, birth weight year birth. Outcomes were investigated through parental questionnaire. primary outcome the Strength Difficulties Questionnaire score...
This study investigated whether a correlation existed between surgical findings during the first laparotomy for necrotising enterocolitis (NEC) and death and, or, disease progression.We included infants admitted within one day of birth to our tertiary neonatal department at Rigshospitalet, Denmark, from 2006 2015, who underwent acute NEC. They were classified according locality extent intestinal necrosis by paediatric surgeon, based on findings. We correlated with postoperative outcomes,...
Abstract Objective To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks gestational age) has changed in neonatal intensive care units (NICUs) SafeBoosC-III consortium during global lockdown when compared to corresponding time period 2019. Design This is a retrospective, observational study. Forty-six out 79 NICUs (58%) from 17 countries participated. Principal investigators were asked report following information: 1) Total EP infant admissions their NICU...