Miguel Alsina Casanova
A5015284099- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Poisoning and overdose treatments
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Neonatal Health and Biochemistry
- Neuroscience of respiration and sleep
- Neurological and metabolic disorders
- Pharmaceutical studies and practices
- Ethics in Clinical Research
- Respiratory Support and Mechanisms
- Erythrocyte Function and Pathophysiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Birth, Development, and Health
- Pancreatitis Pathology and Treatment
- Genetic Syndromes and Imprinting
- Congenital Heart Disease Studies
- Hemoglobinopathies and Related Disorders
- Infant Nutrition and Health
- Blood transfusion and management
- Non-Invasive Vital Sign Monitoring
- Prenatal Substance Exposure Effects
- Syphilis Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Meta-analysis and systematic reviews
Universitat de Barcelona
2015-2025
Hospital Sant Joan de Déu Barcelona
2012-2024
Hospital Clínic de Barcelona
2018-2024
Institut de Recerca Sant Joan de Déu
2024
University of Zurich
2024
Ospedale Filippo Del Ponte Varese
2023
University of Insubria
2023
The use of cerebral oximetry monitoring in the care extremely preterm infants is increasing. However, evidence that its improves clinical outcomes lacking. Download a PDF Research Summary. In this randomized, phase 3 trial conducted at 70 sites 17 countries, we assigned (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by for first 72 birth or usual care. primary outcome was composite death severe brain injury on ultrasonography 36 weeks' postmenstrual...
Importance Red blood cell (RBC) transfusions are frequently administered to preterm infants born before 32 weeks of gestation in the neonatal intensive care unit (NICU). Two randomized clinical trials (Effects Transfusion Thresholds on Neurocognitive Outcomes Extremely Low-Birth-Weight Infants [ETTNO] and Prematures [TOP]) found that liberal RBC transfusion thresholds nonsuperior restrictive thresholds, but extent which these results have been integrated into practice since publication 2020...
Background Bronchopulmonary dysplasia (BPD) is a common cause of morbidity in preterm infants, leading to long-term respiratory complications and risk neurodevelopmental impairment. Although it has multifactorial etiology, local inflammation may play major role. Objectives. We aimed analyze the relationship between nasopharyngeal aspirate (NA) interleukin 6 (IL6) levels clinical imaging findings BPD. Methods: Pilot study infants < 30 weeks . NA was collected at 7 days life (DOL) serial...
Objectives: The objectives are to 1) determine whether there is a positive correlation between the severity of hypoxic-ischemic encephalopathy and multiple organ dysfunction 2) evaluate pattern in infants with hypothermia era. Design: Retrospective observational study prospective data collected April 2009 December 2012. Setting: took place neonatal ICU Hospital Sant Joan de Déu–Hospital Clínic Barcelona. Patients: Prospective consecutive newborns greater than or equal 36 weeks gestation,...
To determine if the efficacy of passive hypothermia and adverse events during transport are related to severity neonatal hypoxic-ischemic encephalopathy.This was a retrospective study 67 infants with encephalopathy, born between April 2009 December 2013, who were transferred for therapeutic cooled transport.Fifty-six newborns (84%) without external sources heat 11 (16%) needed an source. The mean temperature at departure 34.4±1.4°C transfer time 3.3±2.0h. Mean age arrival 5.6±2.5h....
Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks gestational age) differed in neonatal intensive care units (NICUs) SafeBoosC-III consortium during global lockdown when compared to corresponding time period 2019. Design: This is a retrospective, observational study. Forty-six out 79 NICUs (58%) from 17 countries participated. Principal investigators were asked report following information: (1) Total EP infant admissions their NICU 3 months...
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare cause hypertension in newborns. Maternally inherited point mutations Forkhead Box F1 gene (FOXF1), deletions the gene, or its long-range enhancers on maternal allele are responsible for this neonatal lethal disorder. Here, we describe monozygotic twins and one full-term newborn ACD gastrointestinal malformations caused by de novo FOXF1 maternal-inherited alleles. Since parental transmission consistent...
Abstract Background The process of obtaining prior informed consent for experimental treatment does not fit well into the clinical reality acute and intensive care. therapeutic window interventions is often short, which may reduce validity rate enrolled participants, to delay trial completion external results. Deferred ‘opt-out’ are alternative methods. SafeBoosC-III was a randomised investigating benefits harms cerebral oximetry monitoring in extremely preterm infants during first 3 days...
The SafeBoosC-III trial investigated the effect of cerebral oximetry-guided treatment in first 72 h after birth on mortality and severe brain injury diagnosed by cranial ultrasound extremely preterm infants (EPIs). This ancillary study evaluated oximetry global as assessed magnetic resonance imaging (MRI) at term equivalent age (TEA).
Abstract Background Data monitoring of clinical trials is a tool aimed at reducing the risks random errors (e.g. clerical errors) and systematic errors, which include misinterpretation, misunderstandings, fabrication. Traditional ‘good practice data monitoring’ with on-site monitors increases trial costs time consuming for local investigators. This paper aims to outline our approach time-effective central SafeBoosC-III multicentre randomised present results from first three meetings. Methods...
Preterm infants born earlier than 32 weeks of gestational age (GA) often need red blood cell (RBC) transfusions, which have been associated with an increased incidence complications prematurity, due to changes in tissue oxygenation. Transfusion umbilical cord (UCB) could be beneficial for this group. The aims study were: (i) determine the RBC transfusion needs <32 Hospital Clinic Barcelona; (ii) identify target GA group that would benefit most from UCB transfusion; and (iii) assess current...
To determine if the efficacy of passive hypothermia and adverse events during transport are related to severity neonatal hypoxic‐ischemic encephalopathy. This was a retrospective study 67 infants with encephalopathy, born between April 2009 December 2013, who were transferred for therapeutic cooled transport. Fifty‐six newborns (84%) without external sources heat 11 (16%) needed an source. The mean temperature at departure 34.4 ± 1.4 °C transfer time 3.3 2.0 h. Mean age arrival 5.6 2.5...
Introduction Less-invasive surfactant administration (LISA) is associated with better respiratory outcomes in preterm infants distress syndrome. However, mechanical ventilation (MV) shortly after the LISA procedure has been related to lower survival. This study aimed analyze trends and main predictors of continuous positive airway pressure (CPAP) failure LISA. Material methods Preterm born between 23 0 33 6 weeks gestational age (GA) two level III neonatal units who received were included...
Pneumothorax can be a major complication of neonatal lung diseases. We aim to delineate trends and describe the main outcomes related pneumothorax in very preterm infants (VPI).
Abstract Background SafeBoosC-III is a pragmatic, multinational clinical trial evaluating cerebral oximetry-guided treatment for extremely preterm infants. In total, 1601 infants were randomised across 70 sites in Asia, Europe, and USA. To enhance data quality patient care, web-based training program was implemented staff. We now report on the processes. Methods All modules consisted of initial learning material followed by case-based quiz, with elaborate responses to correct as well wrong...
Syphilis is currently an emerging health problem, especially in high-income countries. Infection rates have increased significantly European countries such as the United Kingdom and Spain last 20 years. As a result we are now seeing increase maternal infection, acquired during pregnancy, with high risk of transmission to developing fetus, which associated adverse neonatal outcomes. Although Spanish incidence congenital syphilis below World Health Organization (WHO) elimination threshold...
Anti-Kell alloimmunisation is a potentially severe minor blood group type incompatibility, not only as cause of haemolytic disease the foetus and newborn, but also due to destruction red cells (RBC) mature form in bone marrow with subsequent hyporegenerative anaemia. In cases when shows signs anaemia, an intrauterine transfusion (IUT) may be necessary. When repeated, this treatment can suppress erythropoiesis worsen We report case newborn who required four IUTs plus additional RBC at one...