A5070732816- Diamond and Carbon-based Materials Research
- Quantum optics and atomic interactions
- Quantum Information and Cryptography
- High-pressure geophysics and materials
- Force Microscopy Techniques and Applications
- Atomic and Subatomic Physics Research
- Mechanical and Optical Resonators
- Cold Atom Physics and Bose-Einstein Condensates
- Cancer Genomics and Diagnostics
- Advanced Materials Characterization Techniques
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Fluorescence Microscopy Techniques
- Magnetic Field Sensors Techniques
- Statistical Methods in Clinical Trials
- Photonic and Optical Devices
- Cell Image Analysis Techniques
- Advanced Surface Polishing Techniques
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Advanced NMR Techniques and Applications
- Random lasers and scattering media
- Advanced Causal Inference Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Metabolomics and Mass Spectrometry Studies
- Topological Materials and Phenomena
Anthem (United States)
2021
Center for Astrophysics Harvard & Smithsonian
2012-2021
Harvard University
2012-2021
Chan Zuckerberg Initiative (United States)
2018-2020
Stanford University
2006-2010
Mass spectrometry (MS) is a valuable tool for plasma proteome profiling and disease biomarker discovery. However, wide-ranging protein concentrations, along with technical biological variabilities, present significant challenges deep reproducible quantitation. Here, we evaluated the qualitative quantitative performance of timsTOF HT Pro 2 mass spectrometers analysis neat (unfractionated) Proteograph-processed across wide range peptide loading masses liquid chromatography (LC) gradients. We...
We use the Stokes photon of a biphoton pair to set time origin for electro-optic modulation wave function anti-Stokes thereby allowing arbitrary phase and amplitude modulation. demonstrate conditional single-photon functions composed several pulses, or instead, having Gaussian exponential shapes.
This Letter describes the generation of biphotons with a temporal length that can be varied over range 50-900 ns, an estimated subnatural linewidth as small 0.75 MHz. We make use electromagnetically induced transparency and slow light in two-dimensional magneto-optical trap optical depth high 62. report sharp leading edge spike is Sommerfeld-Brillouin precursor, observed at biphoton level.
We describe a generator of narrow-band paired photons. A single retroreflected Ti:sapphire laser is used to cool, render transparent, and parametrically pump cloud (87)Rb atoms. attain paired-photon generation rate into opposing fibers 600 counts/s with an intensity correlation function that has width 5 ns, violates the Cauchy-Schwartz criteria by factor 2000.
A common limitation of experiments using color centers in diamond is the poor photon collection efficiency microscope objectives due to refraction at interface. We present a simple and effective technique detect large fraction photons emitted by within planar sample detecting light that guided edges via total internal reflection. describe prototype device this "side-collection" technique, which provides approximately 47% detection 39%. apply enhanced signal-to-noise ratio gained from...
We use multi-pulse dynamical decoupling to increase the coherence lifetime (T2) of large numbers nitrogen-vacancy (NV) electronic spins in room temperature diamond, thus enabling scalable applications multi-spin quantum information processing and metrology. realize an order-of-magnitude extension NV T2 for diamond samples with widely differing spin environments. For nitrogen impurity concentration <~1 ppm, we find > 2 ms, comparable longest time reported single centers, demonstrate a...
Under ambient conditions, spin impurities in solid-state systems are found thermally mixed states and optically ``dark''; i.e., the cannot be controlled. Nitrogen-vacancy (NV) centers diamond an exception that electronic ``bright''; they can polarized by optical pumping, coherently manipulated with spin-resonance techniques, read out optically, all at room temperature. Here we demonstrate a scheme to resonantly couple bright NV spins dark substitutional-nitrogen ($P1$) dressing their...
We demonstrate preferential orientation of nitrogen-vacancy (NV) color centers along two four possible crystallographic axes in diamonds grown by chemical vapor deposition on the ${100}$ face. identify relevant growth regime and present a explanation this effect. show that provides increased optical readout contrast for NV multispin measurements, including enhanced ac magnetic-field sensitivity, thus providing an important step towards high-fidelity multispin-qubit quantum information...
Abstract Blood-based approaches to detect early-stage cancer provide an opportunity improve survival rates for lung cancer, the most lethal world-wide. Multiple blood-based detection using molecular analytes derived from individual ‘omics (cell-free DNA, RNA transcripts, proteins, metabolites) have been developed and tested, generally showing significantly lower sensitivity versus late-stage cancer. We hypothesized that approach multiple types of analytes, including broad untargeted coverage...
We describe the observation of a sharp leading-edge spike in biphoton wave packet that is produced using slow light and measured by two-photon correlation. Using stationary-phase approximation we characterize this as Sommerfeld-Brillouin precursor resulting from interference low- high-frequency spectral components.
Deep Learning is a recent and important addition to the computational toolbox available for image reconstruction in fluorescence microscopy. We review state-of-the-art applications such as restoration, super-resolution, light-field imaging, discuss how latest research can be applied other tasks structured illumination, spectral deconvolution, sample stabilisation. Despite its successes, also poses significant challenges, has often misunderstood capabilities, overlooked limits. will address...
We describe a proof-of-principal experiment demonstrating Fourier technique for measuring the shape of biphoton wavepackets. The is based on use synchronously driven fast modulators and slow (integrating) detectors.
We describe a proof-of-principal experiment demonstrating the use of spread spectrum technology at single photon level. show how photons with prescribed temporal shape, in presence interfering noise, may be hidden and recovered.
Abstract The nitrogen vacancy centre in diamond is a leading platform for nanoscale sensing and imaging, as well quantum information processing the solid state. To date, individual control of two electronic spins at has been demonstrated. However, key challenge to scale up such arrays spins. Here, we apply magnetic resonance frequency encoding realize site-selective addressing coherent four-site array Sites are separated by 100 nm, with each site containing multiple vacancies ~15 nm....
Abstract In modern microscopy imaging systems, optical components are carefully designed to obtain diffraction-limited resolution. However, live of large biological samples rarely attains this limit because sample induced refractive index inhomogeneities that create unknown temporally variant aberrations. Importantly, these aberrations also spatially variant, thus making it challenging correct over wide fields view. Here, we present a framework for deep-learning based wide-field aberration...
We describe a method for waveform shaping of narrowband biphotons generated in double-$\ensuremath{\Lambda}$ atomic system via four-wave mixing by periodically modulating the input driving lasers. show that field profile(s) can be revealed two-photon temporal and its correlation measurement.
Type-2 diabetes is associated with severe health outcomes, the effects of which are responsible for approximately 1/4th total healthcare spending in United States (US). Current treatment guidelines endorse a massive number potential anti-hyperglycemic options various combinations. Strategies optimizing selection lacking. Real-world data from nationwide population over one million high-risk diabetic patients (HbA1c ≥ 9%) US analyzed to evaluate comparative effectiveness HbA1c reduction this...
Magnetometry is a powerful technique for the non-invasive study of biological and physical systems. A key challenge lies in simultaneous optimization magnetic field sensitivity maximum range. In interferometry-based magnetometry, quantum two-level system acquires dynamic phase response to an applied field. However, due 2π periodicity phase, increasing coherent interrogation time improve results reduced Here we introduce route towards both large range high via measurements geometric acquired...
Abstract Background Observational studies are increasingly being used to provide supplementary evidence in addition Randomized Control Trials (RCTs) because they a scale and diversity of participants outcomes that would be infeasible an RCT. Additionally, more closely reflect the settings which studied interventions will applied future. Well-established propensity-score-based methods exist overcome challenges working with observational data estimate causal effects. These also quality...
Color centers in nanodiamonds draw interest as an appealing class of fluorescent reporters (fluorophores) for biological labeling. The authors show that two-photon excitation the silicon-vacancy center diamond offers a powerful combination narrow, bright, and nonbleaching emission seems quite promising deep-tissue imaging applications.
Get PDF Email Share with Facebook Tweet This Post on reddit LinkedIn Add to CiteULike Mendeley BibSonomy Citation Copy Text S. Du, P. Kolchin, C. Belthangady, G. Y. Yin, and E. Harris, "Generation of Narrow Bandwidth Paired Photons: Use a single driving laser," in Slow Fast Light, Technical Digest (CD) (Optica Publishing Group, 2006), paper TuA2. Export BibTex Endnote (RIS) HTML Plain alert Save article