A5103240367- CRISPR and Genetic Engineering
- Health and Well-being Studies
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Sirtuins and Resveratrol in Medicine
- Angiogenesis and VEGF in Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer survivorship and care
- Cardiovascular Disease and Adiposity
- Biochemical effects in animals
- Ophthalmology and Visual Health Research
- Cystic Fibrosis Research Advances
- Resilience and Mental Health
- Educational Practices and Challenges
- Cytomegalovirus and herpesvirus research
- Emotional Intelligence and Performance
- Memory Processes and Influences
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Health and Disease Prevention
- Childhood Cancer Survivors' Quality of Life
- Hydrogen's biological and therapeutic effects
- Apelin-related biomedical research
- HIV Research and Treatment
- Reproductive Health and Technologies
University of Tehran
2014-2025
Nationwide Children's Hospital
2024
Zabol University of Medical Sciences
2024
Pennsylvania State University
2021-2023
Örebro University
2013-2022
University of Guilan
2010
Umeå University
1993-1995
The outbreak of the SARS-CoV-2 caused disease COVID-19 to spread globally. Specific and sensitive detection facilitates early intervention prevents from spreading. Here, we present a solid-state CRISPR-Cas12a-assisted nanopore (SCAN) sensing strategy for specific SARS-CoV-2. We introduced nanopore-sized counting method measure cleavage ratio reporters, which is used as criterion positive/negative classification. A kinetic model was developed validated predict reporter size distributions....
Quantification of HIV RNA in plasma is critical for identifying the disease progression and monitoring effectiveness antiretroviral therapy. While RT-qPCR has been gold standard viral load quantification, digital assays could provide an alternative calibration-free absolute quantification method. Here, we reported a Self-digitization Through Automated Membrane-based Partitioning (STAMP) method to digitalize CRISPR-Cas13 assay (dCRISPR) amplification-free HIV-1 RNAs. The Cas13 was designed,...
Clustered regularly interspaced short palindromic repeats (CRISPR)-based nucleic acid-sensing systems have grown rapidly in the past few years. Nevertheless, an objective approach to benchmark performances of different CRISPR sensing is lacking due heterogeneous experimental setup. Here, we developed a quantitative figure merit (FOM) compare methods and explore performance improvement strategies. The FOM defined as product limit detection (LOD) associated reaction time (T). A smaller means...
Introduction: High‐intensity interval training (HIIT) is a form of exercise that enhances capacity and benefits well‐being. Resveratrol naturally occurring polyphenol prevalent in grapes red wine, demonstrating significant health effects on the body. This study sought to evaluate synergistic swimming HIIT resveratrol intake expression SIRTs 4, 5, superoxide dismutases (SOD1 SOD2) frontal lobe elderly rats. Materials Methods: Forty‐five male Wistar rats, aged 22 months, were categorized into...
A pot experiment was carried out in the Horticulture and Landscape Department, College of Agriculture, University Kerbala during spring season 2024. The study aimed to investigate impact thiourea spraying at concentrations 0, 500, 750, 1000 mg L-1 (T0, T1, T2, T3 respectively) boron 25, 50, 100 (B0, B1, B2, B3 on vegetative growth characteristics sweet marjoram. conducted according a randomized complete block design with three replications. results showed differential effect adding factors...
Abstract Acute ischemic stroke (AIS) is the leading cause of mortality and disability worldwide. AIS occur while cerebral arteries become blocked by embolism or thrombosis. Aspiration thrombectomy a promising interventional device to extract massive clots from occluded arteries. The aim this article develop computer‐aided method clarify performance aspiration catheter identify risks for each specific patient. In order simulate process, three‐dimensional fluid‐structure interaction (FSI) was...
Single-stranded DNA (ssDNA) templates along with Cas9 have been used for gene insertion but suffer from low efficiency. Here, we show that ssDNA chemical modifications in 10-17% of internal bases (eDNA) is compatible the homologous recombination machinery. Moreover, eDNA improve by 2-3 fold compared to unmodified and end-modified airway basal stem cells (ABCs), hematopoietic progenitor (HSPCs), T-cells endothelial cells. Over 50% alleles showed three clinically relevant loci (CFTR, HBB,...
BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous disease that usually seen in women of reproductive age and causes complications such as body image dissatisfaction, anxiety, depression. This study was done with the aim comparing effectiveness emotion-focused therapy (EFT) cognitive-behavioral (CBT) on image, depression PCOS. MATERIALS AND METHODS: research semi-experimental pre-test–post-test design control follow-up groups. The statistical population included all PCOS who...
Abstract Single-stranded DNA (ssDNA) templates along with Cas9 have been used for knocking-in exogenous sequences in the genome but suffer from low efficiency. Here, we show that ssDNA chemical modifications 12–19% of internal bases, which denote as enhanced (esDNA), improve knock-in (KI) by 2–3-fold compared to end-modified airway basal stem cells (ABCs), CD34 + hematopoietic (CD34 cells), T-cells and endothelial cells. Over 50% alleles showed KI three clinically relevant loci (CFTR, HBB...
Two experiments addressed the influence of secondary task performance at encoding on recall different features subject‐performed tasks (SPTs) involving objects (e.g., turn wallet). In Experiment 1, memory for verbs and colors was assessed, with object names serving as cues. 2, color were Results from both indicated a greater deterioration under divided attention verbal than colors. addition, intention to remember did not affect any feature in either experiment. The overall pattern outcome is...
Breast cancer is the most common in women, caused by a disorder angiogenesis and apoptosis process. Exercise can affect process of tumor tissue. Thus, aim present study was to investigate changes apoptotic factors mice with breast after 8 weeks exercise training.Sixteen females BALB/c (age: 3-5 weight: 17.1 ± 0.1 g) were randomly divided into two groups aerobic training control. The included 5 sessions per week running an intensity 14-20 m.min-1. HIF-1α, VEGF, miR-21 cytochrome C, Apaf-1,...
The Effect of Six-Week HIIT Swimming Exercise and Resveratrol Supplementation on the Level SIRT3 in Frontal Lobe Aged Rats
One experiment compared the effect of elaboration on enacted and non‐enacted events. The commands were either presented in a basic form (e.g., “wave your hands”) or an enriched form. by adding statements to how perform actions hands as conductor”). Free‐ cued‐recall data showed have dissociative Memory for events benefited from enrichment, whereas simple remembered higher extent than complex Lack benefit memory is suggested be due enactment leading sufficient degree item‐specific processing,...
Insulator-based dielectrophoresis is a recently developed technique in which insulating posts are used to produce non-uniformity the electric field microchannel. This study presents effects of geometry and arrangement on trapping efficiency red blood cells an alternating current- system. Microchannels containing square, circular diamond-shaped with particles under influence positive force fluid flow were considered. Finite element method was compute velocity field. The numerical verified by...
ABSTRACT Cystic fibrosis (CF) is caused by mutations in the cystic transmembrane conductance regulator ( CFTR ) gene. Although many people with CF (pwCF) are treated using modulators, some non-responsive due to their genotype or other uncharacterized reasons. Autologous airway stem cell therapies, which cDNA has been replaced, may enable a durable therapy for all pwCF. Previously, CRISPR-Cas9 two AAVs was used sequentially insert halves of and an enrichment cassette into locus. However,...