Feline atopic skin syndrome (FASS) is a chronic inflammatory disease characterized by itching and dermatitis. While the relationship between gut microbiota dermatitis (AD) has been highlighted, exploring gut-targeted therapies for FASS remain limited. This study aimed to evaluate effects of parasynbiotic containing 1-kestose heat-killed Lactobacillus plantarum FM8 on clinical symptoms in cats with FASS. Eleven were treated (400 mg/day) (2.0 × 1010 CFU/day) 8 weeks. Clinical assessed using...

Staphylococcal exfoliative toxins are involved in some cutaneous infections mammals by targeting desmoglein 1 (Dsg1), a desmosomal cell-cell adhesion molecule. Recently, an toxin gene (exi) was identified Staphylococcus pseudintermedius isolated from canine pyoderma. The aim of this study to identify novel genes S. pseudintermedius. Here, we describe orf the genome impetigo, whose deduced amino acid sequence homologous that SHETB hyicus (70.4%). ORF recombinant protein caused skin...

Abstract Staphylococcal exfoliative toxins are known to digest desmoglein (Dsg) 1, a desmosomal cell–cell adhesion molecule, thus causing intraepidermal splitting in human bullous impetigo, staphylococcal scalded skin syndrome and swine exudative epidermitis. Recently, novel toxin gene ( exi ), whose sequence shares significant homology with previously identified toxins, was isolated from Staphylococcus pseudintermedius . Little is about the pathogenic involvement of this canine pustular...

The strong bond between dogs and their owners creates a close association that could result in the transfer of antibiotic-resistant bacteria from canines to humans, potentially leading spread antimicrobial resistance genes. Pseudomonas aeruginosa, common causative agent persistent ear infections dogs, is often resistant multiple antibiotics. Assessing profile genotype P. aeruginosa crucial for appropriate use veterinary pharmaceuticals. However, recent years, few studies have been conducted...

The spread of antibiotic-resistant bacteria (ARB) in human and veterinary medicine is global concern. Notably, the emergence methicillin-resistant Staphylococcus pseudintermedius has become a serious problem. In this context, bacteriophages their lytic enzymes, endolysins, have received considerable attention as therapeutics for infectious diseases place antibiotics. aim present study was to investigate antibiotic-resistance patterns staphylococcal species isolated from canine skin at...

Pseudomonas aeruginosa is an environmentally ubiquitous and important opportunistic human pathogen responsible for life-threatening health care-associated infections. Because of its extensive repertoire virulence determinants intrinsic acquired resistance mechanisms, the organism could be one most clinically epidemiologically causes morbidity mortality.

Hypothesis/Objectives To describe the clinical, histological and immunological findings of an equine case pemphigus vulgaris, including demonstration antidesmoglein (anti‐Dsg) autoantibodies. Case report The diagnosis vulgaris was confirmed in a 9‐year‐old Welsh pony stallion with both direct indirect immunofluorescence immunoprecipitation studies, latter identifying circulating anti‐Dsg3 IgG. Treatment immunosuppressive medications initiated. Lesions were seen perineal area, sheath, mane,...

The susceptibility of 218 extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae isolates from companion animals to three cephamycins (cefmetazole, flomoxef, and latamoxef) was investigated. Phenotypic testing found 8 120 Klebsiella pneumoniae (KP) 15 69 Enterobacter cloacae (EC) were ESBL AmpC (ABL) co-producers. Isolates KP, Proteus mirabilis, EC that only produced exhibited rates cefmetazole (95.5%, 82.7%, 9.3%), flomoxef (99.1%, 96.6%, 74.0%), latamoxef 100%, 100%),...

A six‐year‐old, neutered, female golden retriever was presented with generalised, dark purple to black cutaneous nodules and gastrointestinal haemorrhage. Histopathologically, all were diagnosed as benign cavernous haemangiomas. Endoscopic analysis revealed similar in the oesophagus, stomach duodenum. At laparotomy, seen on visceral peritoneal lining of abdominal organs. Metastatic haemangiosarcoma ruled out based histological features lack primary tumour spleen, liver or heart...

Background Oclacitinib is an effective systemic therapy for dogs with atopic dermatitis (AD). Few studies have evaluated concurrent topical treatment oclacitinib in dogs. Objectives To evaluate the efficacy and safety of combination 0.0584% hydrocortisone aceponate (HCA) spray AD. Animals Eighteen Methods materials This study was a randomized, double‐blinded, placebo‐controlled trial. All were treated (0.4–0.6 mg/kg twice daily 14 days, then once days) randomized to receive either HCA or...

Abstract Background Polyunsaturated fatty acids (PUFA) can be beneficial in the management of canine atopic dermatitis (cAD). A commercial product PCSO‐524 containing PUFA has demonstrated anti‐inflammatory effects dogs. Hypothesis/Objectives To evaluate efficacy PCSO‐524, combination with oclacitinib dogs cAD. Animals Seventeen client‐owned Materials and Methods randomised, double‐blinded, controlled trial. All were treated (0.4–0.6 mg/kg) twice a day for 14 days, then once until Day (D)42....

Abstract Background IgE reactivity to fish allergens in atopic dogs, which are used as models for food allergy, has not been elucidated date. We investigated crude extracts and purified derived from the Pacific cod ( Gadus macrocephalus ) dogs identify allergenic proteins of cod. Results The levels specific were measured sera 179 including 27 with using enzyme-linked immunosorbent assay (ELISA). Specific present 36 (20%) 12 (44%) allergy. analyzed by ELISA, immunoblotting, liquid...

A locally bred, 12-year-old, intact female Satsuma dog presented with generalized alopecia. Erythema, crusts and desquamation were observed primarily on the truck. Papules erosions present in pinnae, there multiple areas of skin necrosis right forelimb. The cutaneous lesions had not responded to treatment systemic antibiotics prednisolone. also progressive anemia. Babesia gibsoni was detected blood, treated antiprotozoal agents. anemia improved, but relapsed after discontinued....

Background Antimicrobial resistance in Staphylococcus pseudintermedius (SP) and the prevalence of meticillin‐resistant SP (MRSP) is increasing dogs worldwide. Objectives To evaluate influence hospital size on antimicrobial whether restricted use antimicrobials based antibiograms could reduce identification from infected dogs. Methods materials In Study 1, a total 2,294 isolates with pyoderma (n = 1,858, 52 hospitals) or otitis externa (OE; n 436, 44 taken between 2017 2019 were analysed....

Streptococcus canis causes deep pyoderma in canines, which raises concerns about the risk of isolates from lesions acquiring an antibiotic-resistant phenotype. It is necessary to identify effective antibiotics and characteristics pathogenic cluster for S. canis-associated pyoderma.The signalment, molecular typing, status isolated (27 strains) oral cavities (26 were analyzed. Older dogs tended have (15 27 over 10 years old). Veterinarians chose quinolones 10/16 cases (63%), even though rate...

Background Antifungal shampoos are widely used for canine Malassezia dermatitis. Few studies have evaluated effective bathing methods atopic dogs with overgrowth. Objectives To evaluate the efficacy of an emollient product (AFLOAT VET) and 2% miconazole/2% chlorhexidine shampoo (2% MIC/CHX) in dogs, to influence on skin barrier function both products healthy dogs. Animals Sixteen secondary overgrowth 11 Methods materials This study was a randomized, single‐blinded trial. The were randomly...

Background – Cefovecin has been widely used to treat skin infections in dogs. The relationship of the cefovecin disk‐diffusion test results presence mecA gene and clinical efficacy have not fully evaluated. Hypothesis/Objectives To determine usefulness an vitro predicting Staphylococcus pseudintermedius , as well vivo therapy dogs with superficial pyoderma. Methods Twenty‐six S. strains isolated from 22 pyoderma were used. In compared agar‐dilution results, gene, improvement scores at 14...

Persistent papillomatosis on footpads related to canine papillomavirus type 2 (CPV-2) infection has been described in dogs with immunocompromised condition. A 9-year-old, male French bulldog was presented cauliflower-like nodules the of his left front leg. Histopathological examination revealed multiple finger-like projections squamous epithelium intranuclear inclusion bodies. Immunohistochemistry using an anti-bovine antibody demonstrated immunostaining keratinocytes. Partial genome DNA...

Sarcoidosis is a granulomatous disease histologically characterized by naked granulomas in various mammals. Canine sarcoidosis rare which can cause nonpruritic papule, plaques and nodules on the trunk, neck, face ear; it usually treated with corticosteroids. To date, there are no published reports alternatives to corticosteroids treatment.To report case of canine cutaneous successfully oral ciclosporin.An 11-year-old beagle dog was presented multiple pleomorphic lateral thighs dorsal...

過去の報告において，中毒性表皮壊死症（TEN）の犬では角化細胞のアポトーシスが認められなかったことが報告されている。本報告では，表皮内にアポトーシス細胞が検出された犬の1例について報告する。13歳，雌の雑種犬が，主に腹部皮膚や可視粘膜に急性かつ広範な紅斑，水疱および潰瘍を認めたとのことで来院した。本症例では食欲不振および元気消失も認められた。本症例では皮膚症状が発症する5日前よりアモキシシリンが経口投与されていた。皮膚病変の組織学的検査では表皮全層にわたる凝固壊死やリンパ球の表皮内浸潤が認められ，これらの所見はTENに矛盾しないものであった。免疫組織化学染色により，浸潤していたリンパ球はCD3陽性であることが示された。さらに本症例では，アポトーシス細胞を示すTdT-mediated dUTP end labeling（TUNEL）陽性細胞が，角化細胞を含む表皮細胞中に認められた。上記の所見から，本症例ではT細胞に由来する表皮角化細胞のアポトーシスが，表皮壊死の病因となった可能性が示唆された。

Staphylococcus coagulans (SC) belongs to a group of coagulase-positive staphylococci occasionally isolated from the skin lesions dogs with pyoderma. We recently revealed that erythritol, sugar alcohol, inhibited growth SC strain JCM7470. This study investigated molecular mechanisms involved in this inhibition JCM7470 by and determine whether erythritol inhibits Comprehensive analysis gene expression presence upregulated glcB ptsG genes, both which encode phosphotransferase system (PTS)...

Abstract Background Fine bubble (FB) bathing has shown benefits on a mouse model of atopic dermatitis (AD). However, its efficacy in dogs with AD remains to be evaluated. Objective This study aimed assess the clinical effectiveness FB AD. Animals Seventeen whose presentation showed Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI‐04) score <40. Materials Methods The were randomly assigned either group or shampoo group. treatments administered once week as per...